MULTILAYERED WOVEN MANUFACTURE AND USE OF THE MULTILAYER WOVEN MANUFACTURE AS CARRIERS FOR DRIED MATRIX SPOT APPLICATIONS

• US 20150004360A1
• Filed: 12/21/2012
• Published: 01/01/2015
• Est. Priority Date: 12/22/2011
• Status: Active Grant

• Current Assignee: DSM IP Assets BV (DSM-Firmenich AG)
• Original Assignee: DSM IP Assets BV (DSM-Firmenich AG)
• Inventors: Mengerink, Ynze, Mommers, Johannes Helena Michael, Qiu, Jun
• Granted Patent: US 9,630,374 B2
• Time in Patent Office: Days
• US Class Current: 428/137
• CPC Class Codes: B01J 20/28023 Fibres or filaments fibres or filaments in the form of membranes B01J20/28038; B01J20/28007 takes precedence
• CPC Class Codes: B01J 20/28033 Membrane, sheet, cloth, pad, lamellar or mat
• CPC Class Codes: B01J 20/28035 with more than one layer, e.g. laminates, separated sheets
• CPC Class Codes: B01J 20/28038 Membranes or mats made from fibers or filaments
• CPC Class Codes: B01J 20/28052 Several layers of identical or different sorbents stacked in a housing, e.g. in a column
• CPC Class Codes: B01J 20/28054 characterised by their surface properties or porosity
• CPC Class Codes: B01J 20/28095 Shape or type of pores, voids, channels, ducts
• CPC Class Codes: B01L 2200/12 Specific details about manufacturing devices
• CPC Class Codes: B01L 2300/069 Absorbents; Gels to retain a fluid
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2300/0874 Three dimensional network
• CPC Class Codes: B01L 2300/0887 Laminated structure
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: B01L 3/508 rigid containers not provided for above
• CPC Class Codes: B32B 2250/20 All layers being fibrous or filamentary
• CPC Class Codes: B32B 2262/0276 Polyester fibres
• CPC Class Codes: B32B 2307/728 Hydrophilic
• CPC Class Codes: B32B 5/024 Woven fabric
• CPC Class Codes: B32B 5/12 characterised by the relative arrangement of fibres or filaments of different layers, e.g. the fibres or filaments being parallel or perpendicular to each other
• CPC Class Codes: B32B 5/26 another layer next to it also being fibrous or filamentary relative arrangement of fibres or filaments of different layers B32B5/12
• CPC Class Codes: G01N 33/48 : Biological material, e.g. blood, urine G01N33/02, G01N33/26, G01N33/44, G01N33/46 take precedence; Haemocytometers counting blood corpuscules distributed over a surface by scanning the surface G06M11/02
• CPC Class Codes: G01N 33/5302 : Apparatus specially adapted for immunological test procedures
• CPC Class Codes: Y10T 428/24074 : Strand or strand-portions
• CPC Class Codes: Y10T 428/24091 : with additional layer[s]
• CPC Class Codes: Y10T 428/24099 : On each side of strands or strand-portions
• CPC Class Codes: Y10T 428/24107 : including mechanically interengaged strands, strand-portions or strand-like strips
• CPC Class Codes: Y10T 428/24124 : Fibers
• CPC Class Codes: Y10T 428/24132 : including grain, strips, or filamentary elements in different layers or components parallel
• CPC Class Codes: Y10T 428/24322 : Composite web or sheet
• CPC Class Codes: Y10T 428/24967 : Absolute thicknesses specified
• CPC Class Codes: Y10T 442/153 : Including an additional scrim layer
• CPC Class Codes: Y10T 442/2484 : Coating or impregnation is water absorbency-increasing or hydrophilicity-increasing or hydrophilicity-imparting
• CPC Class Codes: Y10T 442/3179 : Woven fabric is characterized by a particular or differential weave other than fabric in which the strand denier or warp/weft pick count is specified
• CPC Class Codes: Y10T 442/3472 : Woven fabric including an additional woven fabric layer
• CPC Class Codes: Y10T 442/3528 : Three or more fabric layers
• CPC Class Codes: Y10T 442/3667 : Composite consisting of at least two woven fabrics bonded by an interposed adhesive layer [but not two woven fabrics bonded together by an impregnation which penetrates through the thickness of at least one of the woven fabric layers]
• CPC Class Codes: Y10T 442/3976 : Including strand which is stated to have specific attributes [e.g., heat or fire resistance, chemical or solvent resistance, high absorption for aqueous composition, water solubility, heat shrinkability, etc.]

Abstract

The invention relates to a substantially laminary manufacture comprising 2 substantially laminary layers in contact, wherein the layers comprise a woven, hydrophilic material.

Claims

1. Use of a substantially laminary manufacture comprising two substantially laminary layers in contact, wherein the layers comprise a woven, hydrophilic material, as a carrier for dried matrix spot applications, preferably as a carrier for dried blood spot applications.

18. Use of the manufacture of claim 1 as a carrier for dried matrix spot applications, preferably as a carrier for dried blood spot applications.

2. A substantially laminary manufacture comprising two substantially laminary layers in contact, wherein the layers comprise a woven, hydrophilic material

3. The manufacture according to claim 2, wherein the layers comprise material with a mesh opening between 11 μ

m and 800 μ

m and a layer thickness between 38 μ

m and 520 μ

m, an open area between 1% and 65%, a mesh count warp between 270 and 9 n/cm, a mesh count weft between 206 n/cm and 9 n/cm, a wire diameter warp and a wire diameter weft between 24 n/cm and 480 μ

m.

4. The manufacture according to claim 3, wherein the layers comprise material with a mesh opening between 20 μ

m and 200 μ

m and a layer thickness between 38 μ

m and 200 μ

m, an open area between 30 and 50%, a mesh count warp between 100 n/cm and 200 n/cm, a mesh count weft of between 100 n/cm and 200 n/cm, a wire diameter warp and a wire diameter weft both between 24 μ

m and 50 μ

m.

5. The manufacture according to claim 4, wherein the layers comprise material with a mesh opening of about 40 μ

m and a layer thickness of about 38 μ

m, an open area of about 40%, a mesh count warp of about 158 n/cm, a mesh count weft of about 158 n/cm, a wire diameter warp and a wire diameter weft between of both about 24 μ

m.

6. The manufacture according to claim 2, wherein both layers consist of the same material, preferably all layers consist of the same material.

7. The manufacture according to claim 2, wherein the manufacture comprises 2 to 18 layers of said material, preferably 3 to 15 layers of said material, more preferably 4 to 12 layers of said material, more preferably about 8 layers or about 4 layers of said material.

8. The manufacture according to claim 2, wherein the layers are kept in contact by laser welding, ultrasonic welding, punctual glue, laminar glue or by using a rigid framework.

9. The manufacture according to claim 2, further comprising a rigid, laminary sheet or framework in contact with one of said layers.

10. The manufacture of claim 9, wherein the sheet comprises one or more holes.

11. The manufacture of claim 9, wherein the sheet is in contact with 2 or more distinct manufactures of any one of the claims 2 to 8, all of which are situated behind the holes.

12. The manufacture according to claim 2, having a front surface adapted for receiving of fluid during use, and the area difference, Δ

A, between a first dried blood spot and a second dried blood spot is less than 20%, where the area of the first dried blood spot is the area of a 30 μ

l 80% hematocrit blood sample on the surface after drying 2 hours at 20°

C. in air and the area of the second dried blood spot is the area of a 30 μ

l 20% hematocrit blood sample on the surface after drying 2 hours at 20°

C. in air;

preferably the area difference, Δ

A, between a first dried blood spot and a second dried blood spot is less than 15%, more preferably the area difference, Δ

A, between a first dried blood spot and a second dried blood spot is less than 10%, and most preferably the area difference, Δ

A, between a first dried blood spot and a second dried blood spot is less than 8%.

13. The manufacture according to claim 2, wherein a first of the two substantially laminary layers is rotated by an angle, v₁₂, to a second of the two substantially laminary layers, and the angle, v₁₂, is 7°

to 83°

;

preferably the angle, v₁₂, is 10°

to 80°

, and more preferably the angle, v₁₂, is 13°

to 77°

.

14. The manufacture according to claim 13, comprising a third substantially laminary layer connected to the second of the two substantially laminary layers and the third substantially laminary layer is rotated by an angle, v₂₃, to the second of the two substantially laminary layers, and the angle, v₂₃, is substantially the same magnitude and opposite direction than the angle v₁₂ so that the angle, v₁₃, between the first of the two substantially laminary layers and the third substantially laminary layer is about zero.

15. The manufacture according to claim 13, comprising a third substantially laminary layer connected to the second of the two substantially laminary layers and the third substantially laminary layer is rotated by an angle, v₂₃, to the second of the two substantially laminary layers, whereby the angle, v₁₃, between the first of the two substantially laminary layers and the third substantially laminary layer as well as the angle v₂₃ are 7°

to 83°

;

preferably the angles v₁₃ and v₂₃ are 10°

to 80°

, and more preferably the angles v₁₃ and v₂₃, are 13°

to 77°

.

16. The manufacture according to claim 2, the manufacture having a front surface adapted for receiving of fluid during use, and a back surface facing away from the front surface, wherein the back surface is impermeable for water.

17. Manufacture according to claim 2, the manufacture having a front surface adapted for receiving of fluid during use, and a back surface facing away from the front surface, and the manufacture comprising at least three substantially laminary layers, wherein substantially laminary layers forming the front surface and/or the back surface have a lower mesh opening than at least one substantially laminary layer arranged between the substantially laminary layers forming the front surface and the back surface.