DIFFUSION BARRIERS AND SPACER MEMBRANES FOR ENZYMATIC IN-VIVO SENSORS
First Claim
1. An electrode system for measuring a concentration or presence of an analyte under in-vivo conditions, the electrode system comprising:
- an electrode having immobilized enzyme molecules thereupon;
an optional diffusion barrier that controls diffusion of the analyte from an exterior of the electrode system to the immobilized enzyme molecules; and
a spacer membrane that forms at least a portion of an outer layer of the electrode system, wherein the spacer membrane comprises a hydrophilic copolymer of acrylic and/or methacrylic monomers, and wherein the hydrophilic copolymer comprises more than 50 mol-% hydrophilic monomers.
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Accused Products
Abstract
An electrode system is disclosed for measuring a concentration or presence of an analyte under in-vivo conditions, where the electrode system includes at least one electrode with immobilized enzyme molecules and an improved diffusion barrier that controls diffusion of the analyte from body fluid surrounding the electrode system to the enzyme molecules. The diffusion barrier includes a hydrophilic polyurethane or a block copolymer having at least one hydrophilic block and at least one hydrophobic block. The electrode system also can include a spacer membrane that includes a hydrophilic copolymer of acrylic and/or methacrylic monomers.
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Citations
20 Claims
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1. An electrode system for measuring a concentration or presence of an analyte under in-vivo conditions, the electrode system comprising:
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an electrode having immobilized enzyme molecules thereupon; an optional diffusion barrier that controls diffusion of the analyte from an exterior of the electrode system to the immobilized enzyme molecules; and a spacer membrane that forms at least a portion of an outer layer of the electrode system, wherein the spacer membrane comprises a hydrophilic copolymer of acrylic and/or methacrylic monomers, and wherein the hydrophilic copolymer comprises more than 50 mol-% hydrophilic monomers. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A spacer membrane for an electrode system comprising:
a hydrophilic copolymer of acrylic and/or methacrylic monomers, wherein the hydrophilic copolymer comprises more than about 50 mol-% hydrophilic monomers as the spacer membrane for the enzymatic electrode system. - View Dependent Claims (20)
Specification