NON-INVASIVE SENSING OF BIOPROCESS PARAMETERS
First Claim
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1. A system for measuring at least one bioprocess analyte or bioprocess parameter, comprising:
- a culture vessel for containing a culture medium, wherein at least one portion of the culture vessel wall comprises a barrier membrane that is at least partially permeable to at least one predetermined analyte; and
a sensor mounted adjacent to the barrier membrane such that the barrier membrane is positioned between the sensor and the culture medium when a culture medium is present in the culture vessel, wherein the sensor is positioned such that the at least one predetermined analyte must pass through the barrier membrane in order to come into contact with the sensor, and wherein the sensor is adapted to chemically interact with the at least one predetermined analyte or to physically react to the at least one bioprocess parameter.
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Abstract
A system and method for measuring at least one bioprocess parameter utilizes a barrier that separates an external sensor from a culture medium. The barrier allows analytes to diffuse in and out of the culture vessel, thereby allowing the bioprocess parameter to be measured non-invasively by the external sensor.
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Citations
28 Claims
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1. A system for measuring at least one bioprocess analyte or bioprocess parameter, comprising:
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a culture vessel for containing a culture medium, wherein at least one portion of the culture vessel wall comprises a barrier membrane that is at least partially permeable to at least one predetermined analyte; and a sensor mounted adjacent to the barrier membrane such that the barrier membrane is positioned between the sensor and the culture medium when a culture medium is present in the culture vessel, wherein the sensor is positioned such that the at least one predetermined analyte must pass through the barrier membrane in order to come into contact with the sensor, and wherein the sensor is adapted to chemically interact with the at least one predetermined analyte or to physically react to the at least one bioprocess parameter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 22, 23, 24, 25, 26, 27)
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18. A system for measuring at least one bioprocess parameter, comprising:
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a culture vessel for containing a culture medium, wherein the culture vessel is defined by at least one culture vessel wall; a recess formed in a portion of the culture vessel wall such that the thickness of the culture vessel wall in the recessed area is sufficiently thin so as to be at least partially permeable to at least one predetermined analyte; and a sensor positioned in the recess such that the culture vessel wall is positioned between the sensor and the culture medium when a culture medium is present in the culture vessel, wherein the sensor is positioned such that the at least one predetermined analyte must pass through the culture vessel wall in the recessed area in order to come into contact with the sensor, and wherein the sensor is adapted to chemically interact with the at least one predetermined analyte or to physically react to the at least one bioprocess parameter. - View Dependent Claims (19, 20, 21)
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28. A system for measuring at least one bioprocess parameter, comprising:
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a culture vessel for containing a culture medium, wherein the culture vessel is defined by at least one culture vessel wall; at least two separate recesses formed in portions of the culture vessel wall such that the thickness of the culture vessel wall in the recessed areas is sufficiently thin so as to be at least partially permeable to at least one predetermined analyte; and a sensor positioned in each recess such that the culture vessel walls in the recessed areas are positioned between the sensors and the culture medium when a culture medium is present in the culture vessel, wherein the sensors are positioned such that the at least one predetermined analyte must pass through the culture vessel wall in the recessed areas in order to come into contact with the sensors, and wherein the sensor is adapted to react to the at least one predetermined analyte.
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Specification