TIME DEPENDENT DRUG DELIVERY APPARATUS

• US 20150011965A1
• Filed: 08/14/2012
• Published: 01/08/2015
• Est. Priority Date: 01/31/2012
• Status: Active Grant

• Current Assignee: West Pharma. Services IL, Ltd. (West Pharmaceutical Services Incorporated)
• Original Assignee: Medimop Medical Projects Ltd. (West Pharmaceutical Services Incorporated)
• Inventors: Cabiri, Oz
• Granted Patent: US 10,335,545 B2
• Time in Patent Office: Days
• US Class Current: 604/500
• CPC Class Codes: A61M 2205/276 preventing unwanted use
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 2205/36 related to heating or cooling
• CPC Class Codes: A61M 2205/3613 by body heat
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/702 automatically during use
• CPC Class Codes: A61M 2205/8212 with means or measures taken for minimising energy consumption
• CPC Class Codes: A61M 2230/50 Temperature
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: A61M 5/44 having means for cooling or heating the devices or media
• CPC Class Codes: G16H 20/13 delivered from dispensers
• CPC Class Codes: G16H 40/60 for the operation of medical equipment or devices
• CPC Class Codes: G16H 40/67 for remote operation

Abstract

An apparatus are disclosed for autonomous variable rate delivery of a substance. In some embodiments, the delivery apparatus may be programmable. In some embodiments, the delivery apparatus may be disposable. Optionally the rate of delivery may be dependent on a temperature of a component of the apparatus. Optionally, there may be a time delay between activation of the apparatus and delivery power of the substance.

Claims

1-31. -31. (canceled)

32. A drug delivery apparatus, comprising:

a temperature sensitive component;

a temperature sensor in thermal communication with the temperature sensitive component to sense the temperature of the temperature sensitive component;

a transcutaneous device;

a discharge mechanism coupled to the transcutaneous device to deliver a drug via the transcutaneous device; and

a processor controlling the discharge mechanism to cause the discharge mechanism to wait for a fixed time delay and adjust the fixed time delay based upon the temperature of the temperature sensitive component.

33. The drug delivery apparatus of claim 32, wherein the temperature sensitive component is the drug.

34. The drug delivery apparatus of claim 32, wherein the temperature sensitive component is a power source that powers the drug delivery apparatus.

35. The drug delivery apparatus of claim 32, further comprising a drug reservoir having the drug therein.

36. The drug delivery apparatus of claim 32, wherein the temperature sensitive component is the drug reservoir.

37. The drug delivery apparatus of claim 32, wherein the processor controls delivery rate of the drug based upon output of the temperature sensor.

38. The drug delivery apparatus of claim 32, further comprising a memory coupled to the processor.

39. The drug delivery apparatus of claim 38, wherein the processor controls delivery rate of the drug by the discharge mechanism based upon output of the temperature sensor and instructions programmed into the memory.

40. The drug delivery apparatus of claim 38, further comprising a programming interface coupled to the memory.

41. The drug delivery apparatus of claim 32, further comprising an insertion mechanism coupled to the transcutaneous device and controlled by the processor to insert the transcutaneous device.

42. The drug delivery apparatus of claim 32, further comprising an insertion mechanism controlled by the processor to insert the transcutaneous device after the fixed time delay.

43. The drug delivery apparatus of claim 32, further comprising a deactivation mechanism deactivating the apparatus after delivery of the drug.

44. The drug delivery apparatus of claim 43, wherein the deactivation mechanism deactivates the apparatus after delivery of a prescribed quantity of the drug from the discharge mechanism.

45. The drug delivery apparatus of claim 32, further comprising a lock mechanism that prevents tampering with the drug delivery apparatus.

46. The drug delivery apparatus of claim 32, further comprising a user interface that decreases and increases the rate of drug delivery.

47. The drug delivery apparatus of claim 46, wherein the user interface increases the rate of drug delivery up to about 200%.

48. The drug delivery apparatus of claim 46, wherein the user interface increases the rate of drug delivery up to about 50%.

49. The drug delivery apparatus of claim 32, further comprising a heater that heats at least one component of the drug delivery apparatus or the drug.

50. A drug delivery apparatus, comprising:

a temperature sensitive component;

a temperature sensor that senses the temperature of the temperature sensitive component;

a transcutaneous device;

a discharge mechanism that delivers a drug via the transcutaneous device;

a drug reservoir that stores the drug therein; and

a processor that controls the discharge mechanism, causes the discharge mechanism to wait for a fixed time delay before activation of the discharge mechanism, and adjusts the fixed time delay based upon the temperature of the temperature sensitive component.

51. The drug delivery apparatus of claim 50, wherein the temperature sensitive component is at least one of the drug, the drug reservoir, or a power source for the drug delivery apparatus.

52. The drug delivery apparatus of claim 50, wherein the length of the fixed time delay is an estimated time for the temperature sensitive component to reach a preferred working temperature.

53. The drug delivery apparatus of claim 50, further comprising a deactivation mechanism coupled to the processor.

54. The drug delivery apparatus of claim 53, wherein the deactivation mechanism performs at least one of protecting a needle, preparing the apparatus for disposal, or permanently disabling the apparatus.

55. A method for drug delivery, comprising the following steps:

sensing a temperature of a temperature sensitive component with a temperature sensor;

delivering a drug via a transcutaneous device with a discharge mechanism; and

controlling the discharge mechanism, using a processor that causes the discharge mechanism to wait for a fixed time delay before activation of the discharge mechanism, and adjusts the fixed time delay based upon the temperature of the temperature sensitive component.

56. The method of claim 55, further comprising determining a rate of delivery of the drug based on a temperature of the temperature sensitive component.

57. The method of claim 55, further comprising heating the drug.

58. The method of claim 55, further comprising:

loading the drug into a drug reservoir coupled to the discharge mechanism and locking the drug delivery apparatus after loading with a locking mechanism.

59. The method of claim 55, further comprising deactivating the portable drug delivery apparatus after delivery of the drug.

60. The method of claim 59, wherein the step of deactivating includes at least one of protecting a needle, preparing the portable drug delivery apparatus for disposal, and disabling the portable drug delivery apparatus.

61. The method of claim 55, further comprising:

activating the drug delivery apparatus, and

programming the processor to set the fixed time delay to at least two minutes after activation.

62. The method of claim 55, wherein the fixed time delay is based on a time for the temperature sensitive component to equilibrate.