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ZIRCONIUM-RADIOLABELED, CYSTEINE ENGINEERED ANTIBODY CONJUGATES

  • US 20150017094A1
  • Filed: 06/10/2014
  • Published: 01/15/2015
  • Est. Priority Date: 09/23/2004
  • Status: Abandoned Application
First Claim
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1. A zirconium-labelled, cysteine-engineered antibody comprising a cysteine engineered antibody (Ab) conjugated through a free cysteine amino acid to a linker (L) and a zirconium complex (Z), having Formula I:


  • Ab-(L-Z)p



    Iwhere p is 1 to 4;

    wherein Z comprises zirconium complexed to desferrioxamine B (Df); and

    wherein L-Df is selected from;

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