Methods and Compositions for Treating Skin Diseases and Conditions

• US 20150017227A1
• Filed: 07/11/2014
• Published: 01/15/2015
• Est. Priority Date: 07/11/2013
• Status: Abandoned Application

• Current Assignee: Epitop, Inc.
• Original Assignee: Epitop, Inc., National Jewish Health
• Inventors: Leung, Donald Y.M., Kim, Byung Eui
• Application Number:
  US14/329,321
• Publication Number:
  US 20150017227A1
• Time in Patent Office: Days
• US Class Current: 424/450
• CPC Class Codes: A61K 31/015 carbocyclic
• CPC Class Codes: A61K 31/045 Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
• CPC Class Codes: A61K 31/05 Phenols cannabinoids A61K31/658
• CPC Class Codes: A61K 31/122 having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• CPC Class Codes: A61K 31/16 Amides, e.g. hydroxamic acids
• CPC Class Codes: A61K 31/20 having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
• CPC Class Codes: A61K 31/22 of acyclic acids, e.g. pravastatin
• CPC Class Codes: A61K 31/222 with compounds having aromatic groups, e.g. dipivefrine, ibopamine
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders

Abstract

Disclosed are methods and compositions for treating skin diseases or conditions with a composition containing a lipid component as an active ingredient.

Claims

1. A method of treating a skin disease or condition in an animal, the method comprising administering to the animal a composition comprising a lipid component selected from the group consisting of alpha-thujene, alpha-pinene, camphene, sabinene, beta-pinene, alpha-terpinene, benzene, limonene, peltay2-carene, trans sabinene hydrate, terpinolene, 3-cyclohexen-1-ol, terpinene-4-ol, 1,2-benzenediol, linalyl acetae, borneol, bornyl acetate, alph-thujone, terpinyl acetate, isolongifolene, epit-bicyclosesquiphellandrene, alpha-humulene, guaiol, elemol, cedrol, beta-eudesmol, rosifoliol, rimuene, hexadecanoic acid, cembrene, verticellol, totarol, totara-1,9-octadecenamide, tatarol, 2-(hexylthiol)decanal and combinations thereof, as an active ingredient.

2. The method of claim 1 wherein the skin disease or condition is an inflammatory skin disease or condition.

3. The method of claim 2 wherein the inflammatory skin disease or condition is selected from the group consisting of atopic dermatitis, contact dermatitis, seborrhoic dermatitis, and acne.

4. The method of claim 3, wherein the inflammatory skin disease or condition is atopic dermatitis.

5. The method of claim 1 wherein the skin disease or condition is selected from the group consisting of xeroderma, psoriasis, and ichthyosis.

6. The method of claim 1, wherein the skin disease or condition is a skin wound.

7. The method of claim 1, wherein the lipid component comprises terpinyl acetate, guaiol, elemol, sabinene, palmitic acid, thujopsene, totarol, 9-octadecenamide, β

-pinene and cembrene.

8. The method of claim 1, wherein the lipid component consists essentially of terpinyl acetate, guaiol, elemol, sabinene, palmitic acid, thujopsene, totarol, 9-octadecenamide, β

-pinene and cembrene.

9. The method of claim 1, wherein the lipid component consists of terpinyl acetate, guaiol, elemol, sabinene, palmitic acid, thujopsene, totarol, 9-octadecenamide, 3-pinene and cembrene.

10. The method of claim 1, wherein the lipid component induces expression of filaggrin.

11. The method of claim 1, wherein the lipid component induces expression of beta-degensin-3 (HBD-3).

12. The method of claim 1, wherein the lipid component attenuates the inhibitory effect of proinflammatory cytokines on filaggrin expression, wherein the proinflammatory cytokine is a Th2 cytokine selected from the group consisting of IL-4, IL-13, IL-25, IL-31, and IL-33.

13. The method of claim 1, wherein the lipid component attenuates the inhibitory effect of proinflammatory cytokines on beta-defensin-3 expression, wherein the proinflammatory cytokine is a Th2 cytokine selected from the group consisting of IL-4, IL-13, IL-25, IL-31, and IL-33.

14. The method of claim 1, wherein the lipid component is non-toxic and protects keratinocytes.

15. The method of claim 1 wherein the composition is administered topically or transdermally.

16. The method of claim 1, wherein the composition is in a form selected from the group consisting of a solution, a gel, a solid, an emulsion, a suspension, a microemulsion, microcapsules, microgranules, ionic (liposome) and non-ionic vesicles, cream, skin lotion, an ointment, powder, a spray, a conceal stick, foam and aerosol.

17. A method of inducing expression of filaggrin in keratinocytes of an animal in need thereof comprising administering to the animal a composition comprising a lipid component selected from the group consisting of alpha-thujene, alpha-pinene, camphene, sabinene, beta-pinene, alpha-terpinene, benzene, limonene, peltay2-carene, trans sabinene hydrate, terpinolene, 3-cyclohexen-1-ol, terpinene-4-ol, 1,2-benzenediol, linalyl acetae, borneol, bornyl acetate, alph-thujone, terpinyl acetate, isolongifolene, epit-bicyclosesquiphellandrene, alpha-humulene, guaiol, elemol, cedrol, beta-eudesmol, rosifoliol, rimuene, hexadecanoic acid, cembrene, verticellol, totarol, totara-1,9-octadecenamide, tatarol, 2-(hexylthiol)decanal and combinations thereof as an active ingredient, wherein the lipid component induces expression of filaggrin.

18. A method of inducing expression of beta-defensin-3 in keratinocytes of an animal in need thereof comprising administering to the animal a composition comprising a lipid component elected from the group consisting of alpha-thujene, alpha-pinene, camphene, sabinene, beta-pinene, alpha-terpinene, benzene, limonene, peltay2-carene, trans sabinene hydrate, terpinolene, 3-cyclohexen-1-ol, terpinene-4-ol, 1,2-benzenediol, linalyl acetae, borneol, bornyl acetate, alph-thujone, terpinyl acetate, isolongifolene, epit-bicyclosesquiphellandrene, alpha-humulene, guaiol, elemol, cedrol, beta-eudesmol, rosifoliol, rimuene, hexadecanoic acid, cembrene, verticellol, totarol, totara-1,9-octadecenamide, tatarol, 2-(hexylthiol)decanal and combinations thereof as an active ingredient, wherein the lipid component induces expression of beta-defensin.

19. A method for preventing a skin disease or condition in an animal, the method comprising administering to the animal a composition comprising a lipid component selected from the group consisting of alpha-thujene, alpha-pinene, camphene, sabinene, beta-pinene, alpha-terpinene, benzene, limonene, peltay2-carene, trans sabinene hydrate, terpinolene, 3-cyclohexen-1-ol, terpinene-4-ol, 1,2-benzenediol, linalyl acetae, borneol, bornyl acetate, alph-thujone, terpinyl acetate, isolongifolene, epit-bicyclosesquiphellandrene, alpha-humulene, guaiol, elemol, cedrol, beta-eudesmol, rosifoliol, rimuene, hexadecanoic acid, cembrene, verticellol, totarol, totara-1,9-octadecenamide, tatarol, 2-(hexylthiol)decanal and combinations thereof as an active ingredient and wherein the skin disease or condition is skin cancer or skin burn from UV exposure.

20. A pharmaceutical composition comprising a pharmaceutically-acceptable carrier, and a lipid component selected from the group consisting of alpha-thujene, alpha-pinene, camphene, sabinene, beta-pinene, alpha-terpinene, benzene, limonene, peltay2-carene, trans sabinene hydrate, terpinolene, 3-cyclohexen-1-ol, terpinene-4-ol, 1,2-benzenediol, linalyl acetae, borneol, bornyl acetate, alph-thujone, terpinyl acetate, isolongifolene, epit-bicyclosesquiphellandrene, alpha-humulene, guaiol, elemol, cedrol, beta-eudesmol, rosifoliol, rimuene, hexadecanoic acid, cembrene, verticellol, totarol, totara-1,9-octadecenamide, tatarol, 2-(hexylthiol)decanal and combinations thereof.

21. A lipid fraction wherein the fraction comprises one or more of the following lipids selected from the groups consisting of alpha-thujene, alpha-pinene, camphene, sabinene, beta-pinene, alpha-terpinene, benzene, limonene, peltay3-carene, trans sabinene hydrate, terpinolene, 3-cyclohexen-1-ol, terpinene-4-ol, 1,2-benzenediol, linalyl acetae, borneol, bornyl acetate, alph-thujone, terpinyl acetate, isolongifolene, epit-bicyclosesquiphellandrene, alpha-humulene, guaiol, elemol, cedrol, beta-eudesmol, rosifoliol, rimuene, hexadecanoic acid, cembrene, verticellol, totarol, totara-1,9-octadecenamide, tatarol, 2-(hexylthiol)decanal and combinations thereof.

22. The lipid fraction of claim 21 wherein the lipid fraction comprises one or more of the following lipids selected from the group consisting of terpinyl acetate, guaiol, elemol, sabinene, palmitic acid, thujopsene, totarol, 9-octadecenamide, β

-pinene and cembrene.

23. The lipid fraction of claim 21, wherein one or more of the lipids are synthetically produced.

24. The lipid fraction of claim 21 wherein one or more of the lipids are extracted from the leaves of Chamaecyparis obtusa.