TISSUE PATHLENGTH RESOLVED NONINVASIVE ANALYZER APPARATUS AND METHOD OF USE THEREOF
First Claim
1. An apparatus for determination of an analyte property of a subject, comprising:
- a near-infrared analyzer, comprising;
a source configured to deliver a sub-microsecond burst of near-infrared light in the range of 1000 to 2500 nanometers;
a temporal resolution gating system configured to collect signal from the burst of near-infrared light during a time period of at least one time delayed gated window, the time period comprising a period greater than one femtosecond and less than one nanosecond after a midpoint of the burst of the near-infrared light; and
a data processing system configured to use the signal and the time period of the at least one delayed gated window in determination of a glucose concentration.
1 Assignment
0 Petitions
Accused Products
Abstract
An analyzer apparatus and method of use thereof is configured to dynamically interrogate a sample. For example, an analyzer using light interrogates a tissue sample using a temporal resolution system on a time scale of less than about one hundred nanoseconds. Optionally, near-infrared photons are introduced to a sample with a known illumination zone to detection zone distance allowing calculation of parameters related to photon pathlength in tissue and/or molar absorptivity of an individual or group through the use of the speed of light and/or one or more indices of refraction. Optionally, more accurate estimation of tissue properties are achieved through use of: knowledge of incident photon angle relative to skin, angularly resolved detector positions, anisotropy, skin temperature, environmental information, information related to contact pressure, blood glucose concentration history, and/or a skin layer thickness, such as that of the epidermis and dermis.
-
Citations
23 Claims
-
1. An apparatus for determination of an analyte property of a subject, comprising:
a near-infrared analyzer, comprising; a source configured to deliver a sub-microsecond burst of near-infrared light in the range of 1000 to 2500 nanometers; a temporal resolution gating system configured to collect signal from the burst of near-infrared light during a time period of at least one time delayed gated window, the time period comprising a period greater than one femtosecond and less than one nanosecond after a midpoint of the burst of the near-infrared light; and a data processing system configured to use the signal and the time period of the at least one delayed gated window in determination of a glucose concentration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
-
14. A method for determination of an analyte property of a subject having skin, comprising the steps of:
-
delivering a spectral burst of near-infrared light at least within the range of 1000 to 2500 nanometers from a source of an analyzer to an illumination region of the skin of the subject; generating a signal during at least one time period using a temporal resolution gating system to detect the burst of light in at least one time delayed gated window between one hundred picoseconds and one hundred nanoseconds after origination of the burst of the near-infrared light; and processing the signal using the at least one time period and the signal to generate a glucose concentration of the subject. - View Dependent Claims (15, 16, 17, 18, 19, 20)
-
-
21. A method for determination of a glucose concentration of a subject, comprising the steps of:
-
using a temporal resolution analyzer to time near-infrared photon traversal through skin using a time resolved gating system and to gather a signal at a detection time period of the time resolved gating system; and using the detection time period and the signal to noninvasively determine a glucose concentration of the subject. - View Dependent Claims (22, 23)
-
Specification