DYNAMIC SAMPLE MAPPING NONINVASIVE ANALYZER APPARATUS AND METHOD OF USE THEREOF
First Claim
1. A method for determining a concentration of a blood borne analyte of a subject, comprising the steps of:
- collecting a plurality of mapping spectra of the subject using a noninvasive analyzer setup in a first set of optical configurations;
calculating a metric related to skin tissue physiology of the subject using the mapping spectra;
based on the metric, setting up said analyzer in a second set of optical configurations, the first set of optical configurations configured to deliver light to the subject in a manner different than the second set of optical configurations;
collecting subject specific noninvasive spectra of the subject using the second set of optical configurations; and
post-processing the subject specific noninvasive spectra to determine the concentration.
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Abstract
A noninvasive analyzer apparatus and method of use thereof is described using a sample mapping phase to establish one or more analyzer/software parameters used in a subsequent individual and/or group specific data collection phase. For example, in the sample mapping phase distance between incident and collected light is varied as a function of time for collected noninvasive spectra. Spectra collected in the sample mapping phase are analyzed to determine a physiological property of the subject, such as dermal thickness, hydration, collagen density, epidermal thickness, and/or subcutaneous fat depth. Using the physiological property or measure thereof, the analyzer is optically reconfigured for the individual to yield subsequent spectra having enhanced features for noninvasive analyte property determination. Similarly, in the mapping and/or collection phase, the incident light is varied in time in terms of any of: sample probe position, incident light solid angle, incident light angle, depth of focus, energy, and/or intensity.
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Citations
23 Claims
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1. A method for determining a concentration of a blood borne analyte of a subject, comprising the steps of:
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collecting a plurality of mapping spectra of the subject using a noninvasive analyzer setup in a first set of optical configurations; calculating a metric related to skin tissue physiology of the subject using the mapping spectra; based on the metric, setting up said analyzer in a second set of optical configurations, the first set of optical configurations configured to deliver light to the subject in a manner different than the second set of optical configurations; collecting subject specific noninvasive spectra of the subject using the second set of optical configurations; and post-processing the subject specific noninvasive spectra to determine the concentration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. An apparatus for determining a concentration of a blood borne analyte of a subject, comprising:
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a noninvasive analyzer, comprising; a source configured to provide photons; a photon transport system configured to deliver the photons to the subject; and a detector system configured to receive the photons from the subject, said analyzer configured to collect a plurality of mapping spectra of the subject using said analyzer in a first set of optical configurations; and a data processing system, said data processing system configured to; calculate a metric related to skin tissue physiology of the subject using the mapping spectra; and set up said analyzer in a second set of optical configurations, the first set of optical configurations configured to deliver light to the subject in a manner different than the second set of optical configurations, said analyzer configured to collect subject specific noninvasive spectra of the subject using the second optical configuration, and said data processing system configured to post-process the subject specific noninvasive spectra to determine the concentration. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23)
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Specification