Seal Structures for Wet/Dry Automatic Injectors

• US 20150018761A1
• Filed: 07/11/2013
• Published: 01/15/2015
• Est. Priority Date: 07/03/2001
• Status: Abandoned Application

• Current Assignee: Meridian Medical Technologies Incorporated
• Original Assignee: Meridian Medical Technologies Incorporated
• Inventors: Griffiths, Steven, Hill, Robert L.
• Application Number:
  US13/939,647
• Publication Number:
  US 20150018761A1
• Time in Patent Office: Days
• US Class Current: 604/89
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/2073 preventing premature release, e.g. by making use of a safety lock
• CPC Class Codes: A61M 2005/287 by displacing occluding plugs
• CPC Class Codes: A61M 2005/3106 Plugs for syringes without needle
• CPC Class Codes: A61M 2005/3131 specially adapted for improving sealing or sliding
• CPC Class Codes: A61M 2005/3132 having flow passages for injection agents at the distal end of the barrel to bypass a sealing stopper after its displacement to this end due to internal pressure increase
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/7536 allowing gas passage, but preventing liquid passage, e.g. liquophobic, hydrophobic, water-repellent membranes
• CPC Class Codes: A61M 2205/7545 for solid matter, e.g. microaggregates
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/2066 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/284 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/286 upon internal pressure increase, e.g. pierced or burst A61M5/283 takes precedence
• CPC Class Codes: A61M 5/3145 Filters incorporated in syringes
• CPC Class Codes: A61M 5/31513 Piston constructions to improve sealing or sliding
• CPC Class Codes: A61M 5/31596 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/3202 Devices for protection of the needle before use, e.g. caps A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001
• CPC Class Codes: A61M 5/3293 characterised by features of the needle hub
• CPC Class Codes: A61M 5/34 Constructions for connecting the needle , e.g. to syringe nozzle or needle hub connecting catheter tubes to hubs A61M25/0014
• CPC Class Codes: A61M 5/343 : Connection of needle cannula to needle hub, or directly to syringe nozzle without a needle hub A61M5/322 takes precedence
• CPC Class Codes: A61M 5/348 : snap lock, i.e. upon axial displacement of needle assembly A61M5/344 takes precedence

Abstract

An automatic injection device including a housing, a chamber with a first compartment and a second compartment, and a seal structure between the compartments. The seal structure is initially in a sealing condition that seals the first compartment from the second compartment, where the seal includes a plug and an outer sealing member. The plug is slidably movable within the outer sealing member to convert the seal structure from the sealing condition to a mixing condition by opening a path between the first compartment and the second compartment. The automatic injection device also includes a needle assembly and an activation assembly. Activation of the activation assembly causes (1) pressurization of the first compartment, (2) the seal structure to convert from the sealing condition to the mixing condition, and (3) the first and second medicament components to be mixed and forced through the needle assembly.

Claims

1. An automatic injection device for automatically administering a medicament upon actuation thereof, the device comprising:

a housing;

a chamber disposed in the housing and having a first compartment and a second compartment;

a seal structure between the first compartment and the second compartment, the seal structure initially in a sealing condition that seals the first compartment from the second compartment, the seal structure comprising a plug and an outer sealing member that forms a peripheral seal with an interior wall of the chamber, wherein the plug is slidably movable within the outer sealing member to convert the seal structure from the sealing condition to a mixing condition by opening a path between the first compartment and the second compartment through the seal structure, the plug maintaining the same orientation with respect to the outer sealing member as the plug moves to convert the seal structure from the sealing condition to the mixing condition;

a needle assembly connected to the first compartment; and

an activation assembly carried by the housing, wherein activation of the activation assembly causes (1) pressurization of the first compartment, (2) the seal structure to convert from the sealing condition to the mixing condition, and (3) the first and second medicament components to be mixed and forced through the needle assembly.

2. The automatic injection device of claim 1, wherein activation of the activation assembly also causes the plunger to contact and move the seal structure through the first compartment toward the needle assembly.

3. The automatic injection device of claim 1, further comprising a plunger that rearwardly seals the second compartment.

4. The automatic injection device of claim 1, wherein the seal structure further comprises a fluid distributing member that creates a laminar fluid flow into the first compartment from the second compartment after the automatic injection device has been activated causing pressurization of the first compartment.

5. The automatic injection device of claim 1, wherein the seal structure further comprises an annular wiper portion disposed at a front end of the seal structure and extends axially, the wiper portion positioned to engage an interior wall of the first compartment and configured to direct dry medicament particles engaged with the interior wall radially inward as the seal structure moves through the first compartment.

6. The automatic injection device of claim 5, wherein the wiper portion comprises a peripheral lip having an inner surface that extends radially inward as it extends axially rearward.

7. The automatic injection device of claim 1, further comprising an insert mounted in a front end of the chamber adjacent the needle assembly, the insert defining a tapering flow pathway that tapers radially inwardly as it extends axially forward.

8. The automatic injection device of claim 7, wherein the needle assembly comprises a needle support for mounting the needle assembly to the front end of the chamber, the needle support defining a needle assembly chamber having an enlarged rearward end opening of a size that is at least as large as a front end opening of the insert.

9. The automatic injection device of claim 7, further comprising a filter positioned between the needle assembly and the insert.

10. The automatic injection device of claim 1, wherein the first compartment comprises a dry medicament component and the second compartment comprises a liquid medicament component.

11. An automatic injection device containing a medicament for automatically administering the medicament upon actuation thereof, the device comprising:

a housing;

a chamber disposed in the housing and having a first compartment and a second compartment;

a seal structure between the first compartment and the second compartment, the seal structure initially in a sealed condition to maintain the first compartment separate from the second compartment the seal structure converting to a mixing condition in response to activation of the device, the seal structure including;

an outer sealing member that forms a peripheral seal with an interior wall of the chamber, and

a plug spaced radially inward from the outer sealing member, the plug in a first position wherein the plug is sealingly engaged with a surface of the outer sealing member to form a liquid-tight seal between the first and second compartments when the seal structure is in the sealed condition, the plug in a second position when the seal structure is in the mixing condition, the plug remaining stationary in the second position as the liquid component flows through the seal structure and thereafter;

a needle assembly connected to the chamber; and

an activation assembly disposed in the housing wherein activation of the activation assembly causes (1) pressurization of the first compartment (2) the seal structure to convert from the sealed condition to the mixing condition, and (3) contents of the first and second compartments to be mixed and forced through the needle assembly.

12. The automatic injection device of claim 11, wherein the first compartment comprises a dry medicament component and the second compartment comprises a liquid medicament component.

13. The automatic injection, device of claim 12, further comprising a dispersion membrane through which the liquid medicament component flows when the seal structure is in the mixing condition after the automatic injection device has been activated causing pressurization of the first compartment.

14. The automatic injection device of claim 13, wherein the dispersion membrane comprises a hydrophobic acrylic copolymer cast on a non woven nylon support.

15. The automatic injection device of claim 11, wherein the seal structure further comprises an annular wiper portion disposed at a front end of the outer sealing member and extends axially, the wiper portion positioned to engage an interior wall of the first compartment as the seal structure is moved through the first compartment, the wiper portion configured to direct dry medicament particles engaged with the interior wall radially inward as the seal structure moves through the first compartment when in the mixing condition.

16. The automatic injection device of claim 15, wherein the annular wiper portion comprises a peripheral lip having an inner surface that extends radially inward as it extends axially rearward.

17. The automatic injection device of claim 11, wherein the outer sealing member comprises an O-ring that provides an annular seal with the interior wall of the chamber.

18. The automatic injection device of claim 11, wherein the seal structure has a by-pass zone adjacent the plug in the first position and around the plug in the second position.

19. The automatic injection device of claim 11, further comprising a plunger rearwardly sealing the second compartment, wherein activation of the activation assembly causes the plunger to contact and move the seal structure through the first compartment toward the needle assembly.

20. The automatic injection device of claim 11, further comprising an insert mounted in a front end of the chamber adjacent the needle assembly, the insert defining a tapering flow pathway that tapers radially inwardly as it extends axially forward.