DEVICE FOR TREATING LUMEN OF LIVING BODY

• US 20150032087A1
• Filed: 07/28/2014
• Published: 01/29/2015
• Est. Priority Date: 07/29/2013
• Status: Active Grant

• Current Assignee: Terumo Kabushiki Kaisha
• Original Assignee: Terumo Kabushiki Kaisha
• Inventors: SHIBATA, Hideaki, ISHII, Naoki, SAWADA, Satoshi
• Granted Patent: US 9,526,506 B2
• Time in Patent Office: Days
• US Class Current: 604/509
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 17/12036 partial occlusion
• CPC Class Codes: A61B 17/12045 double occlusion, e.g. during anastomosis
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 17/12186 liquid materials adapted to be injected
• CPC Class Codes: A61B 2017/00893 pharmaceutically effective
• CPC Class Codes: A61B 2017/00938 hydrophobic
• CPC Class Codes: A61B 2217/005 with suction drainage system
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 25/1002 characterised by balloon shape A61M25/1006, A61M25/1009 take precedence

Abstract

A device for treating the lumen of a living body includes a shaft insertable into a blood vessel, and a balloon provided on the shaft and shiftable between a deflated state and an expanded state. In the expanded state, the balloon has a recessed portion configured to form a coating chamber which is substantially blocked between an inner surface of the blood vessels and the device for treating the lumen of a living body, a discharge port provided on the recessed portion to discharge a coating substance toward the coating chamber; and a suction port provided on the recessed portion to apply a negative pressure to the coating chamber.

Claims

1. A device for treating a lumen of a living body, comprising:

a shaft configured to be inserted into the lumen of the living body;

an expansion and deflation body provided on the shaft and changeable between a deflated state and an expanded state;

wherein, in the expanded state, the expansion and deflation body includes;

at least one recessed portion configured to form a coating chamber which is substantially blocked between an inner surface of the lumen of the living body and the expansion and deflation body;

a discharge port which is provided on the recessed portion and which discharges a coating substance toward the coating chamber; and

a suction port which is provided on the recessed portion and which aspirates fluid from the coating chamber.

2. The device for treating a lumen of a living body according to claim 1, wherein, in the expanded state, the expansion and deflation body is tubular-shaped and possesses two end portions at opposite axial ends of the body, one of the end portions of the body in the expanded state including an outwardly protruding first protruding portion, the other end portion of the body in the expanded state including an outwardly protruding second protruding portion, the body in the expanded state also including an intermediate portion possessing an outer surface, the first and second protruding portions protruding outwardly beyond the outer surface of the intermediate portion of the body in the expanded state.

3. The device for treating a lumen of a living body according to claim 2, wherein the discharge port opens to a surface of the second protruding portion that faces axially toward the first protruding portion, and wherein the suction port opens to a surface of the first protruding portion that faces axially toward the second protruding portion.

4. The device for treating a lumen of a living body according to claim 2, wherein the recessed portion includes a first inclination portion connected to the first protruding portion and extending towards the second protruding portion, and a second inclination portion connected to the second protruding portion and extending towards the first protruding portion, the first inclination portion being connected to the second inclination portion at a connection portion, the connection portion being most inwardly recessed of the recessed portion between the first protruding portion and the second protruding portion.

5. The device for treating a lumen of a living body according to claim 4, wherein, in the expanded state, the connection portion is disposed at a position axially deviated toward the first protruding portion from a center of the recessed portion.

6. The device for treating a lumen of a living body according to claim 4, wherein a plurality of the discharge ports are circumferentially spaced apart along the first inclination portion, and wherein a plurality of the suction ports are circumferentially spaced apart along the second inclination portion.

7. The device for treating a lumen of a living body according to claim 6, wherein the plurality of discharge ports are also spaced apart along the axial direction of the first inclination portion.

8. The device for treating a lumen of a living body according to claim 4, wherein the plurality of discharge ports are circumferentially spaced apart along the first inclination portion at a position near the connection portion of the first inclination portion and the second inclination portion, and wherein the plurality of suction ports are circumferentially spaced apart along the first inclination portion near the first protruding portion and are circumferentially spaced apart along the second inclination portion near the second protruding portion, the plurality of discharge ports being positioned axially between the suction ports near the first protruding portion and the suction ports near the second protruding portion.

9. The device for treating a lumen of a living body according to claim 1, wherein the expansion and deflation body has a plurality of axially spaced coating portions, each possessing an inclination portion on a discharge port side to which the discharge port is provided connected to an inclination portion on a suction port side to which the suction port is provided, the inclination portion on the discharge port side being axially arranged relative to the inclination portion on the suction port side.

10. A device for treating a lumen of a living body, comprising:

a shaft configured to be inserted into the lumen of the living body;

an expansion and deflation body provided on the shaft and changeable between a deflated state and an expanded state;

wherein, in the expanded state, the expansion and deflation body includes;

at least one axially extending recessed portion that includes a first inclination portion and a second inclination portion that are inclined in different directions and arranged axially adjacent one another to form a coating chamber between an inner surface of the lumen of the living body and the expansion and deflation body in the expanded state when the expansion and deflation body is positioned in the lumen and expanded to the expanded state;

a discharge port on the first inclination portion and on the second inclination portion which discharges a coating substance toward the coating chamber; and

wherein, in the expanded state, a connection portion of the recessed portion at which the first inclination portion and the second inclination portion are connected is disposed at a position axially deviated in a proximal end direction from a center of the recessed portion.

11. The device for treating a lumen of a living body according to claim 10, the expansion and deflation body is tubular-shaped and possesses two end portions at opposite axial ends of the body, one of the end portions of the body in the expanded state including an outwardly protruding first protruding portion, the other end portion of the body in the expanded state including an outwardly protruding second protruding portion, the body in the expanded state also including an intermediate portion possessing an outer surface, the first and second protruding portions protruding outwardly beyond the outer surface of the intermediate portion of the body in the expanded state, the first protruding portion and the second protruding portion being positioned adjacent to or in abutment with an inner surface of the lumen of the living body when the expansion and deflation body is positioned in the lumen in the living body and is expanded to the expanded state.

12. The device for treating a lumen of a living body according to claim 11, wherein the first protruding portion is at a proximal portion of the expansion and deflation body and includes an axially facing outer surface which faces the second protruding portion, the second protruding portion being at a distal portion of the expansion and deflation body and including an axially facing outer surface which faces the first protruding portion, the first inclination portion being directly connected to the axially facing outer surface of the first protruding portion, the second inclination portion being directly connected to the axially facing outer surface of the second protruding portion.

13. The device for treating a lumen of a living body according to claim 11, wherein the discharge port is provided on the first inclination portion, and wherein the second protruding portion includes a plurality of openings configured to discharge a fluid in the coating chamber out of the coating chamber.

14. The device for treating a lumen of a living body according to claim 13, wherein the plurality of openings configured to discharge the fluid in the coating chamber out of the coating chamber are located at the second protruding portion and are configured to define a communication path that communicates the coating chamber with outside of the expansion and deflation body.

15. The device for treating a lumen of a living body according to claim 10, wherein the expansion and deflation body includes an inner balloon that has an inner space communicating with a lumen passing through the shaft that conveys expansion fluid, and an outer balloon that covers the inner balloon, and wherein a flow path communicating with the discharge port is between the inner balloon and the outer balloon.

16. The device for treating a lumen of a living body according to claim 10, wherein the shaft includes a lumen for discharging which communicates with the discharge port, and further comprising means for reducing flow resistance that reduces the flow resistance of the coating substance in the lumen for discharging, the means for reducing flow resistance being provided on an inner surface of the lumen for discharging.

17. The device for treating a lumen of a living body according to claim 10, wherein means for reducing adhesion of the coating substance that reduces adhesion of the coating substance is provided on the surface of the expansion and deflation body.

18. A method for treating a lumen of a living body, comprising:

positioning an expansion and deflation body in the lumen of the living body;

outwardly expanding the expansion and deflation body while the expansion and deflation body is positioned in the lumen of the living body so that the expansion and deflation body is in an expanded state, the expansion and deflation body in the expanded state including at least one recessed portion possessing an outer surface spaced from an inner surface of the lumen of the living body so that a space exists between the outer surface of the recessed portion and an inner surface of the lumen;

discharging a coating substance into the space between the outer surface of the recessed portion and an inner surface of the lumen while the expansion and deflation body is in the expanded state to form a coating layer of the coating substance on the inner surface of the lumen in the living body; and

deflating the expansion and deflation body and removing the expansion and deflation body from the lumen of the living body while the coating layer of the coating substance remains on the inner surface of the lumen in the living body.

19. The method for treating a lumen of a living body according to claim 18, further comprising applying suction to the recessed portion of the expansion and deflation body in the expanded state while the coating substance is being discharged into the recessed portion to aspirate some of the coating substance from the recessed portion.

20. The method for treating a lumen of a living body according to claim 18, wherein, in the expanded state, the expansion and deflation body includes two end portions at opposite axial ends of the recessed portion, one of the end portions of the body in the expanded state including an outwardly protruding first protruding portion, the other end portion of the body in the expanded state including an outwardly protruding second protruding portion, the outwardly expansion of the expansion and deflation body while the expansion and deflation body is positioned in the lumen of the living body further comprising outwardly expanding the expansion and deflation body to cause the first protruding portion and the second protruding portion to contact the inner surface of the lumen while the outer surface of the recessed portion remains spaced from the inner surface of the lumen, the discharging of the coating substance into the recessed portion of the expansion and deflation body occurring when the first and second protruding portions are in contact with the inner surface of the lumen.