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Prediction of Responsiveness to Treatment with Immunomodulatory Therapeutics and Method of Monitoring Abscopal Effects During Such Treatment

  • US 20150037346A1
  • Filed: 02/22/2013
  • Published: 02/05/2015
  • Est. Priority Date: 02/23/2012
  • Status: Active Application
First Claim
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1. A method for predicting efficacy of a therapeutic to enhance antitumor immunity in a patient, wherein the therapeutic is one that targets an immunomodulatory leukocyte membrane protein (ILMP) to enhance immune activity, comprising the step of determining pre-treatment levels of peripheral blood monocytes that are CD14+ and HLA-DRlow (PBM14+HLA-DRlow) in a blood sample from the patient , and comparing the determined pretreatment level to a discrimination threshold, wherein a level of PBM14+HLA-DRlow that is below the discrimination threshold indicate a likelihood of therapeutic efficacy.

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