NUTRITIONAL COMPOSITIONS CONTAINING SYNERGISTIC COMBINATION AND USES THEREOF

• US 20150037455A1
• Filed: 07/31/2013
• Published: 02/05/2015
• Est. Priority Date: 07/31/2013
• Status: Active Grant

• Current Assignee: Mead Johnson Nutrition Company (Reckitt Benckiser Group PLC)
• Original Assignee: Mead Johnson Nutrition Company (Reckitt Benckiser Group PLC)
• Inventors: Berg, Brian, Jouni, Zeina, Wittke, Anja, Waworuntu, Rosaline, Chichlowski, Maciej
• Granted Patent: US 9,609,888 B2
• Time in Patent Office: Days
• US Class Current: 426/2
• CPC Class Codes: A23L 33/115 Fatty acids or derivatives thereof; Fats or oils
• CPC Class Codes: A23L 33/12 Fatty acids or derivatives thereof
• CPC Class Codes: A23L 33/17 Amino acids, peptides or proteins
• CPC Class Codes: A23L 33/21 Addition of substantially indigestible substances, e.g. dietary fibres
• CPC Class Codes: A23L 33/26 Polyol polyesters, e.g. sucrose polyesters; Synthetic sugar polymers, e.g. polydextrose
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/202 having three or more double bonds, e.g. linolenic eicosanoids, e.g. leukotrienes A61K31/557
• CPC Class Codes: A61K 31/685 one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
• CPC Class Codes: A61K 31/702 Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
• CPC Class Codes: A61K 31/7032 attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
• CPC Class Codes: A61K 35/20 Milk; Whey; Colostrum
• CPC Class Codes: A61K 38/018 from milk
• CPC Class Codes: A61K 38/40 Transferrins, e.g. lactoferrins, ovotransferrins

Abstract

A composition and method for enhancing brain development in a pediatric subject, the method including administering to the pediatric subject a nutritional composition having up to about 7 g/100 kcal of a fat or lipid source, wherein the fat or lipid source includes at least about 0.5 mg/100 kcal of milk or non-milk polar lipids; up to about 5 g/100 kcal of a protein source; at least about 15 mg/100 kcal of lactoferrin from a non-human source; about 0.015 g/100 kcal to about 0.15 g/100 kcal of a prebiotic composition including polydextrose and/or galactooligosaccharide; and at least about 5 mg/100 kcal of a source of long chain polyunsaturated fatty acids.

Claims

1. A method for enhancing brain development in a pediatric subject, the method comprising administering to the pediatric subject a nutritional composition comprising:

a. up to about 7 g/100 kcal of a fat or lipid source, wherein the fat or lipid source comprises at least about 0.5 mg/100 kcal polar lipids;

b. up to about 5 g/100 kcal of a protein source;

c. at least about 15 mg/100 kcal of lactoferrin from a non-human source;

d. about 0.015 g/100 kcal to about 0.15 g/100 kcal of a prebiotic composition, wherein the prebiotic composition comprises polydextrose, galactooligosaccharide or a combination thereof; and

e. at least about 5 mg/100 kcal of a source of long chain polyunsaturated fatty acids comprising docosahexaenoic acid.

2. The method of claim 1, wherein the polar lipids are present at a level of about 0.5 mg/100 kcal to about 470 mg/100 kcal.

3. The method of claim 2, wherein the polar lipids are present at a level of about 10 mg/100 kcal to about 350 mg/100 kcal.

4. The method of claim 3, wherein the polar lipids are present at a level of about 20 mg/100 kcal to about 260 mg/100 kcal.

5. The method of claim 1, wherein the polar lipids comprise gangliosides and phospholipids, and further wherein the gangliosides are present at a level of about 0.5 mg/100 kcal to about 18 mg/100 kcal, and the phospholipids are present at a level of about 20 mg/100 kcal to about 250 mg/100 kcal.

6. The method of claim 1, wherein lactoferrin is present at a level of about 10 mg/100 kcal to about 200 mg/100 kcal.

7. The method of claim 6, wherein the lactoferrin is bovine lactoferrin.

8. The method of claim 1, wherein the source of long chain polyunsaturated fatty acids is present more preferably from about 5 mg/100 kcal to about 75 mg/100 kcal.

9. The method of claim 1, wherein polydextrose and galactooligosaccharides comprise at least about 20% of the prebiotic composition.

10. The method of claim 1, wherein the nutritional composition is an infant formula or a growing up milk.

11. A nutritional composition for enhancing brain development in a pediatric subject, comprising:

a. up to about 7 g/100 kcal of a fat or lipid source, wherein the fat or lipid source comprises at least about 0.5 mg/100 kcal polar lipids;

b. up to about 5 g/100 kcal of a protein source;

c. at least about 15 mg/100 kcal of lactoferrin from a non-human source;

d. about 0.015 g/100 kcal to about 0.15 g/100 kcal of a prebiotic composition, wherein the prebiotic composition comprises polydextrose, galactooligosaccharide or a combination thereof; and

e. at least about 5 mg/100 kcal of a source of long chain polyunsaturated fatty acids comprising docosahexaenoic acid.

12. The composition of claim 11, wherein the polar lipids are present at a level of about 0.5 mg/100 kcal to about 470 mg/100 kcal.

13. The composition of claim 12, wherein the polar lipids are present at a level of about 10 mg/100 kcal to about 350 mg/100 kcal.

14. The composition of claim 13, wherein the polar lipids are present at a level of about 20 mg/100 kcal to about 260 mg/100 kcal.

15. The composition of claim 11, wherein the polar lipids comprise gangliosides and phospholipids, and further wherein the gangliosides are present at a level of about 0.5 mg/100 kcal to about 18 mg/100 kcal, and the phospholipids are present at a level of about 20 mg/100 kcal to about 250 mg/100 kcal.

16. The composition of claim 11, wherein lactoferrin is present at a level of about 15 mg/100 kcal to about 300 mg/100 kcal.

17. The composition of claim 16, wherein the lactoferrin is bovine lactoferrin.

18. The composition of claim 11, wherein the source of long chain polyunsaturated fatty acids is present more preferably from about 5 mg/100 kcal to about 75 mg/100 kcal.

19. The composition of claim 11, wherein polydextrose and galactooligosaccharides comprise at least about 20% of the prebiotic composition.

20. The composition of claim 11, wherein the nutritional composition is an infant formula or a growing up milk.