DRUG DELIVERY IMPLANTS

• US 20150038941A1
• Filed: 10/02/2014
• Published: 02/05/2015
• Est. Priority Date: 08/13/2008
• Status: Active Grant

• Current Assignee: SMed TA/TD, LLC. (Sites Medical LLC)
• Original Assignee: SMed TA/TD, LLC. (Sites Medical LLC)
• Inventors: Nebosky, Paul S., Zimmerman, Sarah L., Stalcup, Gregory C., Knapp, Troy D.
• Granted Patent: US 9,561,354 B2
• Time in Patent Office: Days
• US Class Current: 604/506
• CPC Class Codes: A61B 17/56 Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
• CPC Class Codes: A61B 17/60 for external osteosynthesis, e.g. distractors, contractors
• CPC Class Codes: A61B 17/7061 for stabilising vertebrae or discs by improving the condition of their tissues, e.g. using implanted medication or fluid exchange intraosseous injection devices A61B17/3472
• CPC Class Codes: A61B 17/80 Cortical plates , i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
• CPC Class Codes: A61B 17/846 Nails or pins, i.e. anchors without movable parts, holding by friction only, with or without structured surface A61B17/72, A61B17/86 take precedence
• CPC Class Codes: A61B 17/8625 Shanks, i.e. parts contacting bone tissue
• CPC Class Codes: A61B 17/864 hollow, e.g. with socket or cannulated
• CPC Class Codes: A61B 17/866 Material or manufacture
• CPC Class Codes: A61F 2/30 Joints
• CPC Class Codes: A61F 2/34 Acetabular cups
• CPC Class Codes: A61F 2/36 Femoral heads ; Femoral endoprostheses
• CPC Class Codes: A61F 2/40 for shoulders
• CPC Class Codes: A61F 2002/30672 temporary
• CPC Class Codes: A61F 2002/30677 Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2002/3068 the pharmaceutical product being in a reservoir
• CPC Class Codes: A61F 2002/3071 Identification means; Administration of patients
• CPC Class Codes: A61F 2002/30784 Plurality of holes
• CPC Class Codes: A61F 2002/3092 having an open-celled or open-pored structure
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir
• CPC Class Codes: A61F 2250/0089 coded with symbols, e.g. dots, numbers, letters, words
• CPC Class Codes: A61M 31/002 : Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61M 5/14276 : specially adapted for implantation

Abstract

An orthopaedic implant system includes an external fixation device implantable at a selected location within a corporeal body and configured for delivering at least one therapeutic agent to the corporeal body. The external fixation device includes an implantable pin, a sheath coupled with the pin, a reservoir coupled with the sheath and a plurality of channels. The pin defines the plurality of channels. The reservoir is configured for receiving the at least one therapeutic agent. The plurality of channels are configured for conveying the at least one therapeutic agent from the reservoir to a treatment site relative to the corporeal body.

Claims

1. An orthopaedic implant system, comprising:

an external fixation device including an implantable pin, a sheath coupled with said pin, a reservoir coupled with said sheath, and a plurality of channels, said external fixation device being implantable at a selected location within a corporeal body and configured for delivering at least one therapeutic agent to said corporeal body, said reservoir configured for receiving said at least one therapeutic agent, said plurality of channels configured for conveying said at least one therapeutic agent from said reservoir to a treatment site relative to said corporeal body, said pin defining said plurality of channels.

2. The orthopaedic implant system of claim 1, wherein said pin defines said reservoir and includes an exterior surface, said plurality of channels fluidly communicating said reservoir with said exterior surface and thereby being configured for conveying said at least one therapeutic agent from said reservoir to said exterior surface.

3. The orthopaedic implant system of claim 2, further including a porous surface attached to said exterior surface, said porous surface configured for receiving at least one of bone and tissue ingrowth therein, said porous surface including a first side attached to said exterior surface and a second side opposing said first side, said porous surface including a through-hole running from said first side to said second side, said through-hole configured for communicating said at least one therapeutic agent from said first side to said second side and thereby for communicating said at least one therapeutic agent to said treatment site.

4. The orthopaedic implant system of claim 3, further including a surface channel defined by said exterior surface, said surface channel being in communication with and cooperating with one said channel and said through-hole to provide said at least one therapeutic agent from said reservoir to said treatment site.

5. The orthopaedic implant system of claim 3, wherein at least one of said channels is a sub-surface channel, said sub-surface channel and said through-hole being aligned with and cooperating with one another to provide said at least one therapeutic agent from said reservoir to said treatment site.

6. The orthopaedic implant system of claim 2, further including at least one of a second reservoir, a pump, and a port implantable in said corporeal body remote from said external fixation device and connected to said reservoir of said external fixation device by at least one catheter implantable in said corporeal body and thereby configured for delivering said at least one therapeutic agent to said treatment site via said external fixation device.

7. The orthopaedic implant system of claim 2, further including at least one of a second reservoir, a pump, and a port not implantable in said corporeal body but which is connected to said reservoir of said external fixation device by at least one transcutaneous catheter and which is thereby configured for delivering said at least one therapeutic agent to said treatment site via said external fixation device.

8. The orthopaedic implant system of claim 2, further including a cartridge inserted into said reservoir, said cartridge containing said at least one therapeutic agent and being configured for releasing said at least one therapeutic agent into at least one of said reservoir and at least one of said channels such that said at least one therapeutic agent moves away from said reservoir in said at least one channel, said cartridge being removable from said reservoir and replaceable with another cartridge after said external fixation device has been implanted in said corporeal body.

9. The orthopaedic implant system of claim 1, further including a spongy element, said reservoir containing said spongy element.

10. The orthopaedic implant system of claim 2, wherein said pin is one of partially porous and completely porous.

11. The orthopaedic implant system of claim 2, wherein said implant includes only one said reservoir.

12. The orthopaedic implant system of claim 2, wherein said reservoir is configured for being refilled with said at least one therapeutic agent after said external fixation device has been implanted in said corporeal body.

13. The orthopaedic implant system of claim 2, wherein said external fixation device is configured for delivering a plurality of therapeutic agents to said corporeal body via said reservoir and said plurality of channels.

14. A method of using an orthopaedic implant system, said method comprising the steps of:

implanting an orthopaedic implant at a selected location within a corporeal body, said implant including an implantable pin, a sheath coupled with said pin, a reservoir coupled with said sheath, and a plurality of channels, said pin defining said plurality of channels;

receiving at least one therapeutic agent in said reservoir;

conveying said at least one therapeutic agent from said reservoir to a treatment site relative to said corporeal body via said plurality of channels; and

delivering said at least one therapeutic agent to said corporeal body.

15. The method of claim 14, wherein said pin defines said reservoir and includes an exterior surface, said plurality of channels fluidly communicating said reservoir with said exterior surface and thereby conveying said at least one therapeutic agent from said reservoir to said exterior surface.

16. The method of claim 15, further including attaching a porous surface to said exterior surface, said porous surface receiving at least one of bone and tissue ingrowth therein, said porous surface including a first side attached to said exterior surface and a second side opposing said first side, said porous surface including a through-hole running from said first side to said second side, said through-hole communicating said at least one therapeutic agent from said first side to said second side and thereby communicating said at least one therapeutic agent to said treatment site.

17. The method of claim 14, further including refilling said reservoir with said at least one therapeutic agent.

18. The method of claim 14, further including implanting at least one of a second reservoir, a pump, and a port in said corporeal body remote from said implant, connecting at least one of said second reservoir, said pump, and said port to said reservoir of said implant by at least one catheter implanted in said corporeal body, and delivering said at least one therapeutic agent to said treatment site via said implant, said catheter, and at least one of said second reservoir, said pump, and said port.

19. The method of claim 14, further including providing at least one of a second reservoir, a pump, and a port which is not implanted in said corporeal body, connecting at least one of said second reservoir, said pump, and said port to said reservoir of said implant by at least one transcutaneous catheter, and delivering said at least one therapeutic agent to said treatment site via said implant, said catheter, and at least one of said second reservoir, said pump, and said port.

20. The method of claim 14, further including inserting a cartridge into said reservoir, said cartridge containing said at least one therapeutic agent and releasing said at least one therapeutic agent into at least one of said reservoir and at least one of said channels such that said at least one therapeutic agent moves away from said reservoir in said at least one channel, removing said cartridge from said reservoir after said implant has been implanted in said corporeal body, and replacing said cartridge with another cartridge after said implant has been implanted in said corporeal body.