COMPOSITIONS, METHODS AND KITS FOR TREATMENT OF CANCER AND AUTOIMMUNE DISEASES
First Claim
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1. A recombinant fusion protein comprising a first amino acid sequence for IL-21 or functional fragment thereof, and a second amino acid sequence for anti-CD20 antibody or functional fragment thereof.
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Abstract
The present invention is directed to fusion proteins having an IL-21 cytokine portion and an anti-CD20 antibody portion, and methods of using such fusion proteins. The invention also provides pharmaceutical compositions and kits utilizing the IL-21-anti-CD20 fusion proteins. In particular, the methods, kits and compositions of the invention are useful in the treatment of cancer and autoimmune diseases.
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38 Claims
- 1. A recombinant fusion protein comprising a first amino acid sequence for IL-21 or functional fragment thereof, and a second amino acid sequence for anti-CD20 antibody or functional fragment thereof.
- 12. The fusion protein of claim 12, wherein said label is a radiolabel.
Specification