IMMOBILISED BIOLOGICAL ENTITIES
1 Assignment
0 Petitions
Accused Products
Abstract
There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.
6 Citations
50 Claims
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1-18. -18. (canceled)
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19. A process for preparing a non-thrombogenic medical device comprising:
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(a) treating a medical device to present a cationic polymer surface layer which has been functionalized to bear azido groups; and (b) reacting said cationic polymer surface layer which has been functionalized to bear azido groups with an anti-coagulant entity which is functionalized to bear an alkyne group; thereby to attach the anti-coagulant entity to the device through a link comprising a 1,2,3-triazole. - View Dependent Claims (35, 36, 39, 41, 43, 45, 47, 49)
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20. A process for preparing a non-thrombogenic medical device comprising:
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(a) treating a medical device to present a cationic polymer surface layer which has been functionalized to bear alkyne groups; and (b) reacting said cationic polymer surface layer which has been functionalized to bear alkyne groups with an anti-coagulant entity which is functionalized to bear an azido group; thereby to attach the anti-coagulant entity to the device through a link comprising a 1,2,3-triazole. - View Dependent Claims (37, 38, 40, 42, 44, 46, 48, 50)
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21. A process for preparing a non-thrombogenic medical device comprising:
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(a) treating a medical device to present a cationic polymer surface layer; and (b) associating with said cationic polymer surface layer a functionalized cationic polymer bearing a plurality of negatively charged anti-coagulant entities such as a heparin moieties which are attached thereto via a link comprising a 1,2,3-triazole said functionalized cationic polymer bearing a plurality of negatively charged anti-coagulant entities having a net negative charge.
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22. A process for preparing a non-thrombogenic medical device comprising:
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(a) treating a medical device to present an anionic polymer surface layer; (b) associating with said anionic polymer surface layer a functionalized cationic polymer bearing a plurality of negatively charged anti-coagulant entities such as a heparin moieties which are attached thereto via a link comprising a 1,2,3-triazole said functionalized cationic polymer bearing a plurality of negatively charged anti-coagulant entities having a net positive charge. - View Dependent Claims (23)
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24. (canceled)
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25. (canceled)
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26. (canceled)
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27. A process for the production of a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole wherein the process comprises the reaction of a corresponding entity carrying an alkyne group with a corresponding surface carrying an azido group, or the reaction of a corresponding entity carrying an azido group with a corresponding surface carrying an alkyne group.
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28. A process for the production of a device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole wherein the device has a surface which comprises one or more layers of polysaccharide and polyamine, which process comprises the reaction of a corresponding surface having an outer layer of polysaccharide with a polyamine carrying a corresponding entity through a link comprising a 1,2,3-triazole, or the reaction of a corresponding surface having an outer layer of polysaccharide with a polyamine carrying an azide or alkyne group and reacting the resulting product with an entity carrying an alkyne or azido group respectively.
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29. (canceled)
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30. (canceled)
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31. (canceled)
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32. (canceled)
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33. (canceled)
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34. (canceled)
Specification