Diagnostic Marker Compounds And Their Use
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Abstract
The present Invention relates to the monitoring of biological substances, such as non-invasive monitoring of such substances in animal, for examples biomarkers and metabolites. Specifically, the invention further relates to such monitoring using rare earth tagged marker compounds. The invention further relates to such monitoring using laser spectroscopy or Raman spectroscopy. The invention further relates to the use of such monitoring in disease states, such as stroke, neurological disorders and cardiovascular disorders. The invention further relates to novel rare-earth conjugated marker compounds and processes for preparing said rare-earth conjugated compounds
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Citations
34 Claims
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1-16. -16. (canceled)
- 17. A method for the measurement of one or more metabolites in an animal comprising the measurement of a rare earth metal-conjugated marker.
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30. A rare earth metal conjugated compound wherein the compound is selected from one of the following groups:
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(i) a small molecule metabolite; (ii) a lipid; (iii) a peptide; and (iv) a protein. - View Dependent Claims (31, 32, 33)
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34. A method of treating a disease condition in an animal comprising:
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(i) administering Eu3+ or a source thereof to said animal; (ii) optically coupling a body part of said animal with a light source and a light detector; (iii) detecting Eu3+-conjugated lactic acid to generate an optical signal; (iv) processing said optical signal to (a) calculate a level or change in level of Eu3+-conjugated lactic acid; and
or(b) calculate the position of Eu3+-conjugated lactic acid; (v) using said position, level or change in level of lactic acid to aid in treatment of atherosclerosis wherein the level or change in level of Eu3+-conjugated lactic acid in step (iv) is determined using the photoluminescence intensity ratio (=I616/I591).
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Specification