ENHANCED INFUSION-SITE PAIN-REDUCTION FOR DRUG-DELIVERY DEVICES

• US 20150045718A1
• Filed: 03/11/2013
• Published: 02/12/2015
• Est. Priority Date: 03/15/2012
• Status: Active Grant

• Current Assignee: United Therapeutics Corporation
• Original Assignee: SteadyMed Ltd. (United Therapeutics Corporation)
• Inventors: Shlomo, Ian, Rand, Jacob, Rigby, Jonathan
• Granted Patent: US 10,071,209 B2
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/422 Desensitising skin
• CPC Class Codes: A61N 1/0456 Specially adapted for transcutaneous electrical nerve stimulation [TENS]
• CPC Class Codes: A61N 1/0476 Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
• CPC Class Codes: A61N 1/0492 Patch electrodes A61N1/0412, A61N1/0428 take precedence
• CPC Class Codes: A61N 1/36021 for treatment of pain

Abstract

The present invention provides an infusion-patch comprising; a cannula; a base; at least one adhesive region in said base suitable for skin attachment; at least one skin-access area within said base; and at least one conduit in fluid connection with said at least one skin access area, wherein said at least one conduit in fluid connection with said at least one skin access area facilitates the transfer of an anesthetic substance within at least a first anesthetic-reservoir which may be removably attached and in fluid connection with said at least one contact area, promoting delivery of said anesthetic substance to said at least one skin-access areas, and wherein said anesthetic substance delivered to said skin-access areas may be at least partially replenished without removing said in fusion-patch.

Claims

1. An infusion-patch comprising:

a cannula

a base;

at least one adhesive region in said base suitable for skin attachment;

at least one skin-access ara within said base; and

at least one conduit in fluid connection with said at least one skin access area,

wherein said at least one conduit in fluid connection with said at least one skin access area facilitates the transfer of an anesthetic substance within at least a first anesthetic-reservoir which may be removably attached and in fluid connection with said at least one contact area, promoting delivery of said anesthetic substance to said at least one skin-access areas, and wherein said anesthetic substance delivered to said skin-access areas may be at least partially replenished without removing said infusion-patch.

2. The device of claim 1 further comprising an actuator and a drug-reservoir containing a drug to be delivered via said cannula, thereby constituting a patch-pump.

3. The device of claim 1 where said cannula belong to the group including rigid cannulas and flexible cannulas.

4. The device of claim 1 where said at least a first anesthetic-reservoir is integral to said infusion-patch and is compressed in order to propel the anesthetic through said conduits.

5. The device of claim 1 where said infusion-patch further comprises a connector in fluid connection with said cannula, wherein said at least a first anesthetic-reservoir is external to said infusion-patch;

and may be attached to said connector via a mechanism that may be removed and optionally replaced with at least a second anesthetic-reservoir.

6. The device of claim 1 where said anesthetic substance comes in a form including creams, liquids and foams.

7. The device of claim 6, where said anesthetic substance comprises a compound selected from the group of anesthetics, analgesics and anti-inflammatory substances.

8. The device of claim 6, where said anesthetic substance is a toxin isolated from Clostridium botulinum.

9. The device of claim 1, further comprising transcutaneous electrical nerve stimulation (TENS) electrodes for applying transcutaneous electrical nerve stimulation.

10. A method of treating pulmonary arterial hypertension using the infusion-patch of claim 1 to deliver Treprostinil.

11. The method of claim 9, wherein said anesthetic substance is a neurotoxin.

12. The method of claim 10, wherein said neurotoxin is isolated from Clostridium botulinum.