DIAGNOSTIC RADIO FREQUENCY IDENTIFICATION SENSORS AND APPLICATIONS THEREOF

• US 20150056099A1
• Filed: 10/01/2014
• Published: 02/26/2015
• Est. Priority Date: 01/27/2004
• Status: Active Grant

• Current Assignee: Altivera, LLC
• Original Assignee: Altivera, LLC
• Inventors: PEETERS, JOHN P.
• Granted Patent: US 9,470,699 B2
• Time in Patent Office: Days
• US Class Current: 422/69
• CPC Class Codes: A61B 2560/0242 adapted to measure environmental factors, e.g. temperature, pollution
• CPC Class Codes: A61B 2560/0285 Apparatus for single use
• CPC Class Codes: A61B 2560/0412 Low-profile patch shaped housings
• CPC Class Codes: A61B 2560/0462 Apparatus with built-in sensors
• CPC Class Codes: A61B 2562/08 Sensors provided with means for identification, e.g. barcodes or memory chips
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/0008 Temperature signals
• CPC Class Codes: A61B 5/02 Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/1112 Global tracking of patients, e.g. by using GPS
• CPC Class Codes: A61B 5/14514 using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1491 Heated applicators
• CPC Class Codes: A61B 5/150022 for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/150358 Strips for collecting blood, e.g. absorbent optical reagent test strips G01N21/8483; chemical reagent test strips G01N33/4875, G01N33/52
• CPC Class Codes: A61B 5/150793 Electrical or magnetic identification means
• CPC Class Codes: A61B 5/150854 long distance, e.g. between patient's home and doctor's office
• CPC Class Codes: A61B 5/15087 short range, e.g. between console and disposable using implanted devices A61B5/150877
• CPC Class Codes: A61B 5/150969 Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
• CPC Class Codes: A61B 5/150984 : Microneedles or microblades
• CPC Class Codes: A61B 5/157 : Devices characterised by integrated means for measuring characteristics of blood
• CPC Class Codes: A61B 5/411 : Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/4839 : combined with drug delivery
• CPC Class Codes: A61B 5/6833 : Adhesive patches
• CPC Class Codes: A61B 90/98 : using electromagnetic means, e.g. transponders
• CPC Class Codes: A62B 99/00 : Subject matter not provided for in other groups of this subclass
• CPC Class Codes: B01L 2300/08 : Geometry, shape and general structure
• CPC Class Codes: B01L 2300/0816 : Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2300/0819 : Microarrays; Biochips
• CPC Class Codes: B01L 2300/0825 : Test strips
• CPC Class Codes: G01D 21/00 : Measuring or testing not otherwise provided for
• CPC Class Codes: G01K 13/00 : Thermometers specially adapted for specific purposes
• CPC Class Codes: G01N 2035/00881 : network configurations
• CPC Class Codes: G01N 33/12 : Meat; Fish
• CPC Class Codes: G01N 33/146 : containing alcohol
• CPC Class Codes: G01N 33/54373 : involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
• CPC Class Codes: G01N 33/5438 : Electrodes
• CPC Class Codes: G01N 33/58 : involving labelled substances G01N33/53 takes precedence
• CPC Class Codes: G01N 35/00871 : Communications between instruments or with remote terminals
• CPC Class Codes: G06K 19/0717 : the sensor being capable of sensing environmental conditions such as temperature history or pressure
• CPC Class Codes: G06K 19/0723 : the record carrier comprising an arrangement for non-contact communication, e.g. wireless communication circuits on transponder cards, non-contact smart cards or RFIDs
• CPC Class Codes: G08B 31/00 : Predictive alarm systems characterised by extrapolation or other computation using updated historic data
• CPC Class Codes: H04M 1/72412 : using two-way short-range wireless interfaces
• CPC Class Codes: H04M 2250/02 : including a Bluetooth interface
• CPC Class Codes: H04W 64/00 : Locating users or terminals or network equipment for network management purposes, e.g. mobility management
• CPC Class Codes: H04W 80/00 : Wireless network protocols or protocol adaptations to wireless operation
• CPC Class Codes: H04W 84/18 : Self-organising networks, e.g. ad-hoc networks or sensor networks
• CPC Class Codes: H04W 88/02 : Terminal devices
• CPC Class Codes: H04W 88/06 : adapted for operation in multiple networks or having at least two operational modes, e.g. multi-mode terminals
• CPC Class Codes: Y02A 30/00 : Adapting or protecting infrastructure or their operation

Abstract

An integrated passive wireless chip diagnostic sensor system is described that can be interrogated remotely with a wireless device such as a modified cell phone incorporating multi-protocol RFID reader capabilities (such as the emerging Gen-2 standard) or Bluetooth, providing universal easy to use, low cost and immediate quantitative analyses, geolocation and sensor networking capabilities to users of the technology. The present invention can be integrated into various diagnostic platforms and is applicable for use with low power sensors such as thin films, MEMS, electrochemical, thermal, resistive, nano or microfluidic sensor technologies. Applications of the present invention include on-the-spot medical and self-diagnostics on smart skin patches, Point-of-Care (POC) analyses, food diagnostics, pathogen detection, disease-specific wireless biomarker detection, remote structural stresses detection and sensor networks for industrial or Homeland Security using low cost wireless devices such as modified cell phones.

Claims

1. A Lab-on-a-Chip microfluidies sensor for conducting rapid diagnostic measurements that readable directly with a remote wireless RF reader comprising:

conductive leads that enable transmission of signals;

a Lab-on-a-Chip substrate having at least one test area integrated therein and a sensor interface that couples said conductive leads to said test area;

a temperature module integrated with said substrate and adapted to generate signals that correspond to temperature;

an addressable radio frequency (RF) chip having a controller, an RF power source with a voltage stabilization circuit, and a communication interface, said RF chip receiving signals from said conductive leads and said temperature module, said RF chip being adapted to process said conductive lead signals, said temperature module signals and signals from the wireless RF reader; and

at least one antenna adapted to receive signals from the wireless RF reader and said RF chip and transmit signals from said Lab-on-a-Chip microfluidics sensor.

2. The Lab-on-a-Chip device of claim 1, wherein microfluidics sensor is capable of quantitative protein measurements that are readable directly with the wireless RF reader.

3. The Lab-on-a-Chip device of claim 1, wherein microfluidics sensor is capable of quantitative biomarker measurements that are readable directly with the wireless RF reader.

4. The Lab-on-a-Chip device of claim 1, wherein the microfluidics sensor is adapted to perform DNA tests that are readable directly with the wireless RF reader.