JCV NEUTRALIZING ANTIBODIES
First Claim
1. An isolated JC-virus neutralizing monoclonal antibody against JCV capsid protein VP1 (JCV-VP1).
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Accused Products
Abstract
In one aspect, the disclosure provides neutralizing antibodies against JCV and methods for the treatment of PML. In some embodiments, aspects of the invention relate to an isolated JC-virus neutralizing monoclonal antibody against JCV capsid protein VPI (JCV-VP1). In some embodiments, the antibody suppresses infectivity of the JC-virus. In some embodiments, the antibody binds the sialic acid binding pocket of JCV-VPI. In some embodiments, the antibody binds JCV-VP 1 comprising one or more of the following mutations: S269F, S269Y, S267F, N265D, Q271 H, D66H, K60E, K60N and L55F.
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Citations
28 Claims
- 1. An isolated JC-virus neutralizing monoclonal antibody against JCV capsid protein VP1 (JCV-VP1).
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18. An isolated antibody comprising SEQ ID NO:
- 23 (h-18C9 N55H) and SEQ ID NO;
43 (1-18C9 C96S).
- 23 (h-18C9 N55H) and SEQ ID NO;
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19. An isolated antibody comprising a sequence that has at least 80% homology to SEQ ID NO:
- 23 (h-18C9 N55H) and a sequence that has at least 80% homology to SEQ ID NO;
43 (1-18C9 C96S).
- 23 (h-18C9 N55H) and a sequence that has at least 80% homology to SEQ ID NO;
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20. An isolated antibody comprising a sequence that has at least 90% homology to SEQ ID NO:
- 23 (h-18C9 N55H) and a sequence that has at least 90% homology to SEQ ID NO;
43 (1-18C9 C96S).
- 23 (h-18C9 N55H) and a sequence that has at least 90% homology to SEQ ID NO;
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21. An isolated antibody comprising a sequence that has at least 95% homology to SEQ ID NO:
- 23 (h-18C9 N55H) and a sequence that has at least 95% homology to SEQ ID NO;
43 (1-18C9 C96S).
- 23 (h-18C9 N55H) and a sequence that has at least 95% homology to SEQ ID NO;
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22. An isolated antibody comprising a sequence that has up to 10 mutations compared to SEQ ID NO:
- 23 (h-18C9 N55H) and a sequence that has up to 10 mutations compared to SEQ ID NO;
43 (1-18C9 C96S).
- 23 (h-18C9 N55H) and a sequence that has up to 10 mutations compared to SEQ ID NO;
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23. An isolated antibody having heavy chain sequence
Specification