CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS

• US 20150057277A1
• Filed: 01/25/2013
• Published: 02/26/2015
• Est. Priority Date: 01/25/2012
• Status: Active Grant

• Current Assignee: NeuPharma, Inc.
• Original Assignee: NeuPharma, Inc.
• Inventors: Qian, Xiangping, Zhu, Yong-liang
• Granted Patent: US 9,670,180 B2
• Time in Patent Office: Days
• US Class Current: 514/234.8
• CPC Class Codes: A61K 31/498 Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
• CPC Class Codes: A61K 31/5377 not condensed and containing further heterocyclic rings, e.g. timolol
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C07D 241/42 with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
• CPC Class Codes: C07D 241/44 with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
• CPC Class Codes: C07D 401/12 linked by a chain containing hetero atoms as chain links

Abstract

Chemical entities that are quinoxaline kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.

Claims

1. A compound of Formula I

2. The compound or pharmaceutically acceptable salt of claim 1, wherein R₁ is hydrogen, cyano, halo, hydroxy, carboxy, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted alkoxycarbonyl, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryloxy, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbamimidoyl, or optionally substituted alkynyl.

3. The compound or pharmaceutically acceptable salt of claim 2, wherein R₁ is hydrogen, cyano, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted amino, optionally substituted alkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl.

4. The compound or pharmaceutically acceptable salt of claim 3, wherein R₁ is optionally substituted aryl, optionally substituted heterocycloalkyl, or optionally substituted heteroaryl.

5. The compound or pharmaceutically acceptable salt of claim 4, wherein R₁ is optionally substituted morpholinyl, optionally substituted piperazinyl, optionally substituted pyrrolidinyl, optionally substituted piperidinyl, optionally substituted imidazolyl, optionally substituted pyrazolyl, or optionally substituted pyridyl.

6. The compound or pharmaceutically acceptable salt of any one of claims 1 to 5, wherein R₂, R₃, R₄, and R₅ are independently hydrogen, halo, cyano, optionally substituted alkoxy, or optionally substituted alkyl.

7. The compound or pharmaceutically acceptable salt of claim 6, wherein R₂, R₃, R₄, and R₅ are independently hydrogen or halo.

8. The compound or pharmaceutically acceptable salt of claim 7, wherein R₂, R₃, R₄, and R₅ are hydrogen.

9. The compound or pharmaceutically acceptable salt of any one of claims 1 to 8 wherein R₆, R₇, R₈, and R₁₀ are independently hydrogen, cyano, halo, optionally substituted alkoxy, optionally substituted alkyl, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, or optionally substituted aminosulfonyl.

10. The compound or pharmaceutically acceptable salt of claim 9 wherein R₆, R₇, R₈, and R₁₀ are independently hydrogen, cyano, or halo.

11. The compound or pharmaceutically acceptable salt of claim 10 wherein R₆, R₇, R₈, and R₁₀ are independently hydrogen or halo.

12. The compound or pharmaceutically acceptable salt of claim 11, wherein R₆, R₇, R₈, and R₁₀ are independently hydrogen or fluoro.

13. The compound or pharmaceutically acceptable salt of any one of claims 1 to 12, wherein R₉ is hydrogen, optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl.

14. The compound or pharmaceutically acceptable salt of claim 13, wherein R₉ is hydrogen or optionally substituted lower alkyl.

15. The compound or pharmaceutically acceptable salt of claim 14, wherein R₉ is hydrogen.

16. The compound or pharmaceutically acceptable salt of any one of claims 1 to 15, wherein R₁₁ is —

COR₁₂, —

CO₂R₁₂, —

CONR₁₂R₁₃, —

C(NR₁₄)NR₁₂R₁₃, —

C(NCN)NR₁₂R₁₃, —

SO₂NR₁₂, or —

SO₂NR₁₂R₁₃.

17. The compound or pharmaceutically acceptable salt of claim 16, wherein R₁₁ is —

COR₁₂, —

CO₂₁₂, —

CONR₁₂R₁₃, —

SO₂NR₁₂, or —

SO₂NR₁₂R₁₃.

18. The compound or pharmaceutically acceptable salt of claim 17, wherein R₁₁ is —

COR₁₂, or —

CONR₁₂R₁₃.

19. The compound or pharmaceutically acceptable salt of any one of claims 16 to 18, wherein R₁₂ is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl;

and R₁₃ and R₁₄ are independently hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, or optionally substituted heterocycloalkyl.

20. The compound or pharmaceutically acceptable salt of claim 19, wherein R₁₂ is optionally substituted alkyl, optionally substituted aryl, or optionally substituted heteroaryl;

and R₁₃ and R₁₄ are independently hydrogen or optionally substituted alkyl.

21. The compound or pharmaceutically acceptable salt of any one of claims 16 to 18, wherein R₁₂ and R₁₃ are joined together with any intervening atoms to form an optionally substituted 4- to 8-membered heterocycloalkyl ring.

22. The compound or pharmaceutically acceptable salt of any one of claims 1 to 12, wherein R₉ and R₁₁ are joined together with any intervening atoms to form an optionally substituted 4- to 8-membered heterocycloalkyl ring.

24. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound or pharmaceutically acceptable salt of any one of claims 1 to 23.

25. A pharmaceutical composition of claim 24, wherein the composition is formulated in a form chosen from the group consisting of tablets, capsules, powders, liquids, suspensions, suppositories, and aerosols.

26. A packaged pharmaceutical composition comprising a pharmaceutical composition of claim 24 or 25 and instructions for using the composition to treat a subject suffering from cancer.

27. A method of treating cancer in a subject which comprises administering to a subject in need thereof a therapeutically effective amount of a compound or pharmaceutically acceptable salt of any one of claims 1 to 23.

28. The method of claim 26, wherein the cancer is colon carcinoma, pancreatic cancer, breast cancer, ovarian cancer, prostate cancer, thyroid cancer, fibrosarcoma, myxosarcoma, liposarcoma, chondrosarcoma, osteogenic sarcoma, chondroma, angiosarcoma, endotheliosarcoma, lymphangiosarcoma, lymphangioendotheliosarcoma, synovioma, mesothelioma, Ewing'"'"'s tumor, leiomyosarcoma, rhabdomyosarcoma, squamous cell carcinoma, basal cell carcinoma, adenocarcinoma, sweat gland carcinoma, thyroid cancer, sebaceous gland carcinoma, papillary carcinoma, papillary adenocarcinomas, cystadenocarcinoma, medullary carcinoma, bronchogenic carcinoma, renal cell carcinoma, hepatoma, bile duct carcinoma, choriocarcinoma, seminoma, embryonal carcinoma, Wilms'"'"' tumor, cervical cancer, testicular tumor, lung carcinoma, small cell lung carcinoma, non-small cell lung cancer, bladder carcinoma, epithelial carcinoma, glioma, astrocytoma, medulloblastoma, craniopharyngioma, ependymoma, pinealoma, hemangioblastoma, acoustic neuroma, oligodendroglioma, meningioma, melanoma, neuroblastoma, retinoblastoma, leukemia, acute lymphocytic leukemia and acute myelocytic leukemia (myeloblastic, promyelocytic, myelomonocytic, monocytic and erythroleukemia);

chronic leukemia (chronic myelocytic (granulocytic) leukemia and chronic lymphocytic leukemia); and

polycythemia vera, lymphoma (Hodgkin'"'"'s disease and non-Hodgkin'"'"'s disease), multiple myeloma, Waldenstrom'"'"'s macroglobulinemia, or heavy chain disease.

29. The method of claim 28, wherein the cancer is melanoma, non-small cell lung cancer, colon cancer, thyroid cancer, or ovarian cancer.

30. A method of treating a disorder mediated by Raf in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound or pharmaceutically acceptable salt of any one of claims 1 to 23.

31. A method of treating a disorder in a subject in need thereof, comprising:

a. determining the presence or absence of a BRAF mutation in a biological sample isolated from the subject; and

b. if a BRAF mutation is determined to be present in the subject, administering to the subject a therapeutically effective amount of a compound or pharmaceutically acceptable salt of any one of claims 1 to 23.

32. The method of claim 31, wherein the BRAF mutation is in codon 600.

33. The method of claim 31, wherein the BRAF mutation is V600E.

34. The method of claim 31, wherein determining the presence or absence of the BRAF mutation comprises amplifying BRAF nucleic acid from the biological sample and sequencing the amplified nucleic acid.

35. The method of claim 31, wherein determining the presence or absence of the BRAF mutation comprises detecting a mutant BRAF polypeptide in the biological sample using a binding agent to a mutant BRAF polypeptide.

36. The method of claim 35, wherein the binding agent is an antibody.

37. The method of claim 31, wherein the biological sample is isolated from a tumor of the subject.

38. The method of any one of claims 30-37, wherein the disorder is cancer.

39. The method of claim 38, wherein the cancer is colon carcinoma, pancreatic cancer, breast cancer, ovarian cancer, prostate cancer, thyroid cancer, fibrosarcoma, myxosarcoma, liposarcoma, chondrosarcoma, osteogenic sarcoma, chondroma, angiosarcoma, endotheliosarcoma, lymphangiosarcoma, lymphangioendotheliosarcoma, synovioma, mesothelioma, Ewing'"'"'s tumor, leiomyosarcoma, rhabdomyosarcoma, squamous cell carcinoma, basal cell carcinoma, adenocarcinoma, sweat gland carcinoma, sebaceous gland carcinoma, papillary carcinoma, papillary adenocarcinomas, cystadenocarcinoma, medullary carcinoma, bronchogenic carcinoma, renal cell carcinoma, hepatoma, bile duct carcinoma, choriocarcinoma, seminoma, embryonal carcinoma, Wilms'"'"' tumor, cervical cancer, testicular tumor, lung carcinoma, small cell lung carcinoma, non-small cell lung cancer, bladder carcinoma, epithelial carcinoma, glioma, astrocytoma, medulloblastoma, craniopharyngioma, ependymoma, pinealoma, hemangioblastoma, acoustic neuroma, oligodendroglioma, meningioma, melanoma, neuroblastoma, retinoblastoma, leukemia, acute lymphocytic leukemia and acute myelocytic leukemia (myeloblastic, promyelocytic, myelomonocytic, monocytic and erythroleukemia);

chronic leukemia (chronic myelocytic (granulocytic) leukemia and chronic lymphocytic leukemia); and

polycythemia vera, lymphoma (Hodgkin'"'"'s disease and non-Hodgkin'"'"'s disease), multiple myeloma, Waldenstrom'"'"'s macroglobulinemia, or heavy chain disease.

40. The method of claim 39, wherein the cancer is melanoma, non-small cell lung cancer, colon cancer, thyroid cancer, or ovarian cancer.

41. The method of any one of claims 27-40, further comprising administering an additional anti-cancer and/or cytotoxic agent.

23. A compound or pharmaceutically acceptable salt chosen from the group consisting of:

1-(3-chlorophenyl)-3-(3-(quinoxalin-6-yloxy)phenyl)urea

1-(4-chlorophenyl)-3-(3-(quinoxalin-6-yloxy)phenyl)urea

1-(3-fluorophenyl)-3-(3-(quinoxalin-6-yloxy)phenyl)urea

1-(3-(quinoxalin-6-yloxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-(quinoxalin-6-yloxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(3-(quinoxalin-6-yloxy)phenyl)urea

1-(3-fluoro-4-(trifluoromethyl)phenyl)-3-(3-(quinoxalin-6-yloxy)phenyl)urea

1-(3-chloro-4-(trifluoromethyl)phenyl)-3-(3-(quinoxalin-6-yloxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-((3-methylquinoxalin-6-yl)oxy)phenyl)urea

1-(3-((3-methylquinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-((3-cyanoquinoxalin-6-yl)oxy)phenyl)urea

1-(3-((3-cyanoquinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-((3-cyanoquinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-fluorophenyl)-3-(3-((3-methoxyquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-((3-methoxyquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-((3-(2-hydroxyethoxy)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-((3-(2-methoxyethoxy)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-((3-(2-aminoethoxy)quinoxalin-6-yl)oxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-((3-((2-hydroxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-((3-((2-methoxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluorophenyl)-3-(3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-fluorophenyl)-3-(3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(3-chlorophenyl)-3-(3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chlorophenyl)-3-(3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-fluorophenyl)-3-(3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-chlorophenyl)-3-(3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluorophenyl)-3-(3-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-chlorophenyl)-3-(3-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluorophenyl)-3-(3-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-((3-(1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-((3-(4-methyl-1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-fluorophenyl)-3-(3-((3-(4-methyl-1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluorophenyl)-3-(3-((3-(5-methyl-1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-((3-(1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-fluorophenyl)-3-(3-((3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-chlorophenyl)-3-(2,4,5-trifluoro-3-(quinoxalin-6-yloxy)phenyl)urea

1-(4-chlorophenyl)-3-(2,4,5-trifluoro-3-(quinoxalin-6-yloxy)phenyl)urea

1-(3-fluorophenyl)-3-(2,4,5-trifluoro-3-(quinoxalin-6-yloxy)phenyl)urea

1-(2-chloro-4,5-difluoro-3-(quinoxalin-6-yloxy)phenyl)-3-(3-fluorophenyl)urea

1-(2-chloro-4-fluoro-3-(quinoxalin-6-yloxy)phenyl)-3-(3-fluorophenyl)urea

1-(2,4,5-trifluoro-3-(quinoxalin-6-yloxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2,4,5-trifluoro-3-(quinoxalin-6-yloxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(2,4,5-trifluoro-3-(quinoxalin-6-yloxy)phenyl)urea

1-(2,4,5-trifluoro-3-((3-(2-hydroxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(2,4,5-trifluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-chlorophenyl)-3-(2,4,5-trifluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluorophenyl)-3-(2,4,5-trifluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(2,4,5-trifluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2,4,5-trifluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(2,4,5-trifluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(3-chloro-4-(trifluoromethyl)phenyl)-3-(2,4,5-trifluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(2,4,5-trifluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-fluorophenyl)-3-(2,4,5-trifluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(2-chloro-4,5-difluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(2-chloro-4-fluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-chlorophenyl)-3-(2,4,5-trifluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chlorophenyl)-3-(2,4,5-trifluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2,4,5-trifluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(2,4,5-trifluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(2,4,5-trifluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluorophenyl)-3-(2,4,5-trifluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-chlorophenyl)-3-(2,4,5-trifluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluorophenyl)-3-(2,4,5-trifluoro-3-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluorophenyl)-3-(2,4,5-trifluoro-3-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-chlorophenyl)-3-(2,4,5-trifluoro-3-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluorophenyl)-3-(2,4,5-trifluoro-3-((3-(4-methyl-1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-((3-(1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)-2,4,5-trifluorophenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-fluorophenyl)-3-(2,4,5-trifluoro-3-((3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-chlorophenyl)-3-(3,4-difluoro-5-(quinoxalin-6-yloxy)phenyl)urea

1-(4-chlorophenyl)-3-(3,4-difluoro-5-(quinoxalin-6-yloxy)phenyl)urea

1-(3,4-difluoro-5-(quinoxalin-6-yloxy)phenyl)-3-(3-fluorophenyl)urea

1-(3,4-difluoro-5-(quinoxalin-6-yloxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3,4-difluoro-5-(quinoxalin-6-yloxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(3,4-difluoro-5-(quinoxalin-6-yloxy)phenyl)urea

1-(3,4-difluoro-5-(quinoxalin-6-yloxy)phenyl)-3-(3-fluoro-4-(trifluoromethyl)phenyl)urea

1-(3-chloro-4-(trifluoromethyl)phenyl)-3-(3,4-difluoro-5-(quinoxalin-6-yloxy)phenyl)urea

1-(3-((3-cyanoquinoxalin-6-yl)oxy)-4,5-difluorophenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-((3-cyanoquinoxalin-6-yl)oxy)-4,5-difluorophenyl)-3-(3-fluorophenyl)urea

1-(3,4-difluoro-5-((3-(2-hydroxyethoxy)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3,4-difluoro-5-((3-(2-methoxyethoxy)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-((3-(2-aminoethoxy)quinoxalin-6-yl)oxy)-4,5-difluorophenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3,4-difluoro-5-((3-((2-hydroxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3,4-difluoro-5-((3-((2-methoxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3,4-difluoro-5-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-chlorophenyl)-3-(3,4-difluoro-5-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3,4-difluoro-5-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(3,4-difluoro-5-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3,4-difluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(3,4-difluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(3-chloro-4-(trifluoromethyl)phenyl)-3-(3,4-difluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(3,4-difluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3,4-difluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-chlorophenyl)-3-(3,4-difluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chlorophenyl)-3-(3,4-difluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3,4-difluoro-5-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3,4-difluoro-5-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(3,4-difluoro-5-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3,4-difluoro-5-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-chlorophenyl)-3-(3,4-difluoro-5-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3,4-difluoro-5-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3,4-difluoro-5-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-chlorophenyl)-3-(3,4-difluoro-5-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3,4-difluoro-5-((3-(4-methyl-1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-((3-(1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)-4,5-difluorophenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3,4-difluoro-5-((3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-chlorophenyl)-3-(3-fluoro-5-(quinoxalin-6-yloxy)phenyl)urea

1-(4-chlorophenyl)-3-(3-fluoro-5-(quinoxalin-6-yloxy)phenyl)urea

1-(3-fluoro-5-(quinoxalin-6-yloxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-fluoro-5-(quinoxalin-6-yloxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-5-(quinoxalin-6-yloxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(3-fluoro-5-(quinoxalin-6-yloxy)phenyl)urea

1-(3-fluoro-4-(trifluoromethyl)phenyl)-3-(3-fluoro-5-(quinoxalin-6-yloxy)phenyl)urea

1-(3-chloro-4-(trifluoromethyl)phenyl)-3-(3-fluoro-5-(quinoxalin-6-yloxy)phenyl)urea

1-(3-((3-cyanoquinoxalin-6-yl)oxy)-5-fluorophenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-((3-cyanoquinoxalin-6-yl)oxy)-5-fluorophenyl)-3-(3-fluorophenyl)urea

1-(3-fluoro-5-((3-(2-hydroxyethoxy)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-fluoro-5-((3-(2-methoxyethoxy)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-((3-(2-aminoethoxy)quinoxalin-6-yl)oxy)-5-fluorophenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-fluoro-5-((3-((2-hydroxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-fluoro-5-((3-((2-methoxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-fluoro-5-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-chlorophenyl)-3-(3-fluoro-5-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-5-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(3-fluoro-5-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(3-fluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(3-chloro-4-(trifluoromethyl)phenyl)-3-(3-fluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-fluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-chlorophenyl)-3-(3-fluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chlorophenyl)-3-(3-fluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-5-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-5-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(3-fluoro-5-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-5-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-chlorophenyl)-3-(3-fluoro-5-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-5-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-fluoro-5-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-chlorophenyl)-3-(3-fluoro-5-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-5-((3-(4-methyl-1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-((3-(1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)-5-fluorophenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-fluoro-5-((3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-chlorophenyl)-3-(4-fluoro-3-(quinoxalin-6-yloxy)phenyl)urea

1-(4-chlorophenyl)-3-(4-fluoro-3-(quinoxalin-6-yloxy)phenyl)urea

1-(4-fluoro-3-(quinoxalin-6-yloxy)phenyl)-3-(3-fluorophenyl)urea

1-(4-fluoro-3-(quinoxalin-6-yloxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-fluoro-3-(quinoxalin-6-yloxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(4-fluoro-3-(quinoxalin-6-yloxy)phenyl)urea

1-(4-fluoro-3-(quinoxalin-6-yloxy)phenyl)-3-(3-fluoro-4-(trifluoromethyl)phenyl)urea

1-(3-chloro-4-(trifluoromethyl)phenyl)-3-(4-fluoro-3-(quinoxalin-6-yloxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-fluoro-3-((3-methylquinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluoro-3-((3-methylquinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-((3-cyanoquinoxalin-6-yl)oxy)-4-fluorophenyl)urea

1-(3-((3-cyanoquinoxalin-6-yl)oxy)-4-fluorophenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-((3-cyanoquinoxalin-6-yl)oxy)-4-fluorophenyl)-3-(3-fluorophenyl)urea

1-(4-fluoro-3-((3-methoxyquinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-fluoro-3-((3-methoxyquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-fluoro-3-((3-(2-hydroxyethoxy)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-fluoro-3-((3-(2-methoxyethoxy)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-((3-(2-aminoethoxy)quinoxalin-6-yl)oxy)-4-fluorophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-fluoro-3-((3-((2-hydroxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-fluoro-3-((3-((2-methoxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(4-chlorophenyl)-3-(4-fluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(4-fluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-fluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-chlorophenyl)-3-(4-fluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-fluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(3-chloro-4-(trifluoromethyl)phenyl)-3-(4-fluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(4-fluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-fluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-chlorophenyl)-3-(4-fluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chlorophenyl)-3-(4-fluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-fluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-fluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-chlorophenyl)-3-(4-fluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluoro-3-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(4-fluoro-3-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-fluoro-3-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-chlorophenyl)-3-(4-fluoro-3-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluoro-3-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-fluoro-3-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-((3-(1H-imidazol-1-yl)quinoxalin-6-yl)oxy)-4-fluorophenyl)-3-(3-fluorophenyl)urea

1-(4-fluoro-3-((3-(4-methyl-1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-fluoro-3-((3-(4-methyl-1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(4-fluoro-3-((3-(5-methyl-1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-((3-(1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)-4-fluorophenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-fluoro-3-((3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

3-chloro-N-(3-(quinoxalin-6-yloxy)phenyl)benzamide

3-fluoro-N-(3-(quinoxalin-6-yloxy)phenyl)benzamide

4-chloro-3-fluoro-N-(3-(quinoxalin-6-yloxy)phenyl)benzamide

N-(3-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(3-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

3-chloro-N-(3-(quinoxalin-6-yloxy)phenyl)-4-(trifluoromethyl)benzamide

4-chloro-N-(3-(quinoxalin-6-yloxy)phenyl)benzamide

3-chloro-N-(3-((3-methylquinoxalin-6-yl)oxy)phenyl)benzamide

3-fluoro-N-(3-((3-methylquinoxalin-6-yl)oxy)phenyl)benzamide

N-(3-((3-cyanoquinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

3-chloro-N-(3-((3-methoxyquinoxalin-6-yl)oxy)phenyl)benzamide

N-(3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-chloro-N-(3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

3-fluoro-N-(3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-3-fluoro-N-(3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-fluoro-N-(3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-3-fluoro-N-(3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-fluoro-N-(3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

3-chloro-N-(3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-3-fluoro-N-(3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(3-((3-(1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)-4-chloro-3-fluorobenzamide

4-chloro-3-fluoro-N-(3-((3-(4-methyl-1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(3-((3-(1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)phenyl)-4-chloro-3-fluorobenzamide,

3-fluoro-N-(3-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(3-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-fluoro-N-(3-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-3-fluoro-N-(3-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

3-chloro-N-(4-fluoro-3-(quinoxalin-6-yloxy)phenyl)benzamide

3-fluoro-N-(4-fluoro-3-(quinoxalin-6-yloxy)phenyl)benzamide

4-chloro-3-fluoro-N-(4-fluoro-3-(quinoxalin-6-yloxy)phenyl)benzamide

N-(4-fluoro-3-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(4-fluoro-3-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

3-chloro-N-(4-fluoro-3-(quinoxalin-6-yloxy)phenyl)-4-(trifluoromethyl)benzamide

4-chloro-N-(4-fluoro-3-(quinoxalin-6-yloxy)phenyl)benzamide

3-chloro-N-(4-fluoro-3-((3-methylquinoxalin-6-yl)oxy)phenyl)benzamide

3-fluoro-N-(4-fluoro-3-((3-methylquinoxalin-6-yl)oxy)phenyl)benzamide

N-(3-((3-cyanoquinoxalin-6-yl)oxy)-4-fluorophenyl)-3-fluorobenzamide

3-chloro-N-(4-fluoro-3-((3-methoxyquinoxalin-6-yl)oxy)phenyl)benzamide

N-(4-fluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-chloro-N-(4-fluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

3-fluoro-N-(4-fluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-3-fluoro-N-(4-fluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(4-fluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(4-fluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-fluoro-N-(4-fluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-3-fluoro-N-(4-fluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(4-fluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(4-fluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-fluoro-N-(4-fluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

3-chloro-N-(4-fluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(4-fluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-3-fluoro-N-(4-fluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(3-((3-(1H-imidazol-1-yl)quinoxalin-6-yl)oxy)-4-fluorophenyl)-4-chloro-3-fluorobenzamide

4-chloro-3-fluoro-N-(4-fluoro-3-((3-(4-methyl-1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(3-((3-(1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)-4-fluorophenyl)-4-chloro-3-fluorobenzamide

3-fluoro-N-(4-fluoro-3-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(4-fluoro-3-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-fluoro-N-(4-fluoro-3-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-3-fluoro-N-(4-fluoro-3-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

3-chloro-N-(3-fluoro-5-(quinoxalin-6-yloxy)phenyl)benzamide

3-fluoro-N-(3-fluoro-5-(quinoxalin-6-yloxy)phenyl)benzamide

4-chloro-3-fluoro-N-(3-fluoro-5-(quinoxalin-6-yloxy)phenyl)benzamide

N-(3-fluoro-5-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(3-fluoro-5-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

3-chloro-N-(3-fluoro-5-((3-methylquinoxalin-6-yl)oxy)phenyl)benzamide

N-(3-((3-cyanoquinoxalin-6-yl)oxy)-5-fluorophenyl)-3-fluorobenzamide

3-chloro-N-(3-fluoro-5-((3-methoxyquinoxalin-6-yl)oxy)phenyl)benzamide

N-(3-fluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-chloro-N-(3-fluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

3-fluoro-N-(3-fluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-3-fluoro-N-(3-fluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(3-fluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(3-fluoro-5-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-chloro-N-(3-fluoro-5-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

3-fluoro-N-(3-fluoro-5-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-3-fluoro-N-(3-fluoro-5-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(3-fluoro-5-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(3-fluoro-5-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-fluoro-N-(3-fluoro-5-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

3-chloro-N-(3-fluoro-5-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(3-fluoro-5-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-3-fluoro-N-(3-fluoro-5-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(3-((3-(1H-imidazol-1-yl)quinoxalin-6-yl)oxy)-5-fluorophenyl)-4-chloro-3-fluorobenzamide

4-chloro-3-fluoro-N-(3-fluoro-5-((3-(4-methyl-1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(3-((3-(1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)-5-fluorophenyl)-4-chloro-3-fluorobenzamide

3-fluoro-N-(3-fluoro-5-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(3-fluoro-5-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-fluoro-N-(3-fluoro-5-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-3-fluoro-N-(3-fluoro-5-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

3-chloro-N-(3,4-difluoro-5-(quinoxalin-6-yloxy)phenyl)benzamide

N-(3,4-difluoro-5-(quinoxalin-6-yloxy)phenyl)-3-fluorobenzamide

4-chloro-N-(3,4-difluoro-5-(quinoxalin-6-yloxy)phenyl)-3-fluorobenzamide

N-(3,4-difluoro-5-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(3,4-difluoro-5-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(2-chloro-4-fluoro-3-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

N-(2-chloro-4-fluoro-3-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

N-(2-chloro-4-fluoro-3-(quinoxalin-6-yloxy)phenyl)-3-fluorobenzamide

3-fluoro-N-(2,4,5-trifluoro-3-(quinoxalin-6-yloxy)phenyl)benzamide

N-(2,4,5-trifluoro-3-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(2,4,5-trifluoro-3-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-3-fluoro-N-(2,4,5-trifluoro-3-(quinoxalin-6-yloxy)phenyl)benzamide

3-chloro-N-(3,4-difluoro-5-((3-methylquinoxalin-6-yl)oxy)phenyl)benzamide

N-(2-chloro-4-fluoro-3-((3-methylquinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

N-(3-((3-cyanoquinoxalin-6-yl)oxy)-4,5-difluorophenyl)-3-fluorobenzamide

N-(2-chloro-3-((3-cyanoquinoxalin-6-yl)oxy)-4-fluorophenyl)-3-fluorobenzamide

N-(3-((3-cyanoquinoxalin-6-yl)oxy)-2,4,5-trifluorophenyl)-3-fluorobenzamide

3-chloro-N-(3,4-difluoro-5-((3-methoxyquinoxalin-6-yl)oxy)phenyl)benzamide

N-(3,4-difluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-chloro-N-(3,4-difluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

N-(3,4-difluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

4-chloro-N-(3,4-difluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

4-chloro-N-(3,4-difluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-chloro-N-(2-chloro-4-fluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(2-chloro-4-fluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

N-(2-chloro-4-fluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

4-chloro-N-(2,4,5-trifluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-3-fluoro-N-(2,4,5-trifluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

3-fluoro-N-(2,4,5-trifluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

N-(2,4,5-trifluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-chloro-N-(2,4,5-trifluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

N-(3,4-difluoro-5-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-chloro-N-(3,4-difluoro-5-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(3,4-difluoro-5-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

4-chloro-N-(3,4-difluoro-5-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

4-chloro-N-(3,4-difluoro-5-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(2-chloro-4-fluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-chloro-N-(2-chloro-4-fluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(2-chloro-4-fluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

N-(2-chloro-4-fluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

4-chloro-N-(2,4,5-trifluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-3-fluoro-N-(2,4,5-trifluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

3-fluoro-N-(2,4,5-trifluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(2,4,5-trifluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-chloro-N-(2,4,5-trifluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(3,4-difluoro-5-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(3,4-difluoro-5-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

3-chloro-N-(3,4-difluoro-5-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(3,4-difluoro-5-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(3,4-difluoro-5-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

N-(2-chloro-4-fluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(2-chloro-4-fluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

3-chloro-N-(2-chloro-4-fluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(2-chloro-4-fluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

N-(2,4,5-trifluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-fluoro-N-(2,4,5-trifluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

3-chloro-N-(2,4,5-trifluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(2,4,5-trifluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-3-fluoro-N-(2,4,5-trifluoro-3-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(3-((3-(1H-imidazol-1-yl)quinoxalin-6-yl)oxy)-4,5-difluorophenyl)-4-chloro-3-fluorobenzamide

4-chloro-N-(3,4-difluoro-5-((3-(4-methyl-1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

N-(3-((3-(1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)-4,5-difluorophenyl)-4-chloro-3-fluorobenzamide

N-(3,4-difluoro-5-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

N-(3,4-difluoro-5-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(3,4-difluoro-5-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

4-chloro-N-(3,4-difluoro-5-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

N-(3-((3-(1H-imidazol-1-yl)quinoxalin-6-yl)oxy)-2,4,5-trifluorophenyl)-4-chloro-3-fluorobenzamide

4-chloro-3-fluoro-N-(2,4,5-trifluoro-3-((3-(4-methyl-1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(3-((3-(1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)-2,4,5-trifluorophenyl)-4-chloro-3-fluorobenzamide

3-fluoro-N-(2,4,5-trifluoro-3-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

3-fluoro-N-(2,4,5-trifluoro-3-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(3-(quinoxalin-6-yloxy)phenyl)urea

1-(4-cyano-3-(trifluoromethyl)phenyl)-3-(3-(quinoxalin-6-yloxy)phenyl)urea

1-(3-chloro-4-cyanophenyl)-3-(3-(quinoxalin-6-yloxy)phenyl)urea

1-(3,4-dichlorophenyl)-3-(3-(quinoxalin-6-yloxy)phenyl)urea

1-(3,4-difluorophenyl)-3-(3-(quinoxalin-6-yloxy)phenyl)urea

1-(3-chloro-4-fluorophenyl)-3-(3-(quinoxalin-6-yloxy)phenyl)urea

1-(4-cyano-3-fluorophenyl)-3-(3-(quinoxalin-6-yloxy)phenyl)urea

1-(3-((3-(aminomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-((3-(4-methylpiperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-((3-(pyrrolidin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3,4-difluorophenyl)-3-(3-((3-(pyrrolidin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluorophenyl)-3-(3-((3-(pyrrolidin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluorophenyl)-3-(3-((3-(pyrrolidin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(3-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3,4-difluorophenyl)-3-(3-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(3-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-fluorophenyl)-3-(3-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluorophenyl)-3-(3-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-((3-((4-methylpiperazin-1-yl)methyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(3-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3,4-difluorophenyl)-3-(3-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluorophenyl)-3-(3-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluorophenyl)-3-(3-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-((3-(1H-pyrazol-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

1-(3,4-difluorophenyl)-3-(3-((3-((2-hydroxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-((3-((2-aminoethyl)amino)quinoxalin-6-yl)oxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

1-(3-((3-((2-aminoethyl)amino)quinoxalin-6-yl)oxy)phenyl)-3-(3,4-difluorophenyl)urea

1-(4-fluoro-3-(quinoxalin-6-yloxy)phenyl)-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea

1-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-fluoro-3-(quinoxalin-6-yloxy)phenyl)urea

1-(3-chloro-4-cyanophenyl)-3-(4-fluoro-3-(quinoxalin-6-yloxy)phenyl)urea

1-(3,4-dichlorophenyl)-3-(4-fluoro-3-(quinoxalin-6-yloxy)phenyl)urea

1-(3,4-difluorophenyl)-3-(4-fluoro-3-(quinoxalin-6-yloxy)phenyl)urea

1-(3-chloro-4-fluorophenyl)-3-(4-fluoro-3-(quinoxalin-6-yloxy)phenyl)urea

1-(4-cyano-3-fluorophenyl)-3-(4-fluoro-3-(quinoxalin-6-yloxy)phenyl)urea

1-(3-((3-(aminomethyl)quinoxalin-6-yl)oxy)-4-fluorophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-fluoro-3-((3-(pyrrolidin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-fluoro-3-((3-((4-methylpiperazin-1-yl)methyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3,4-difluorophenyl)-3-(4-fluoro-3-((3-(pyrrolidin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluoro-3-((3-(pyrrolidin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(4-fluoro-3-((3-(pyrrolidin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)-3-(4-fluorophenyl)urea

1-(4-fluoro-3-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-fluoro-3-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3,4-difluorophenyl)-3-(4-fluoro-3-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(4-fluoro-3-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluoro-3-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-fluoro-3-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(4-fluoro-3-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(4-fluorophenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-fluoro-3-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluoro-3-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea

1-(3,4-difluorophenyl)-3-(4-fluoro-3-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluoro-3-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)-3-(4-fluorophenyl)urea

1-(4-fluoro-3-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-((3-(1H-pyrazol-1-yl)quinoxalin-6-yl)oxy)-4-fluorophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

1-(3,4-difluorophenyl)-3-(4-fluoro-3-((3-((2-hydroxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-((3-((2-aminoethyl)amino)quinoxalin-6-yl)oxy)-4-fluorophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

1-(3-((3-((2-aminoethyl)amino)quinoxalin-6-yl)oxy)-4-fluorophenyl)-3-(3,4-difluorophenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-fluoro-3-((3-(4-methylpiperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

N-(3-(quinoxalin-6-yloxy)phenyl)propane-1-sulfonamide

N-(4-fluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)propane-1-sulfonamide

N-(4-fluoro-3-(quinoxalin-6-yloxy)phenyl)propane-1-sulfonamide

N-(3-fluoro-5-(quinoxalin-6-yloxy)phenyl)propane-1-sulfonamide

N-(3-fluoro-5-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)propane-1-sulfonamide

1-(3,4-difluorophenyl)-3-(3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluorophenyl)-3-(3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3,5-difluorophenyl)-3-(3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluorophenyl)-3-(3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(3,4-difluorophenyl)-3-(3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(3,5-difluorophenyl)-3-(3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chlorophenyl)-3-(3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3,4-difluorophenyl)-3-(4-fluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(4-fluorophenyl)urea

1-(3,5-difluorophenyl)-3-(4-fluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(3-chloro-4-fluorophenyl)-3-(4-fluoro-3-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(4-fluorophenyl)urea

1-(3,4-difluorophenyl)-3-(4-fluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3,5-difluorophenyl)-3-(4-fluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chlorophenyl)-3-(4-fluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-chloro-4-fluorophenyl)-3-(4-fluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(4-fluoro-3-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-methoxyphenyl)-3-(3-(quinoxalin-6-yloxy)phenyl)urea

1-(4-cyanophenyl)-3-(3-(quinoxalin-6-yloxy)phenyl)urea

1-propyl-3-(3-(quinoxalin-6-yloxy)phenyl)urea

1-cyclopropyl-3-(3-(quinoxalin-6-yloxy)phenyl)urea

1-(3-fluorophenyl)-3-(4-(quinoxalin-6-yloxy)phenyl)urea

1-(3-chlorophenyl)-3-(4-(quinoxalin-6-yloxy)phenyl)urea

1-(4-(quinoxalin-6-yloxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(4-(quinoxalin-6-yloxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-(quinoxalin-6-yloxy)phenyl)urea

1-(3-chloro-4-(trifluoromethyl)phenyl)-3-(4-(quinoxalin-6-yloxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-((3-methylquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-((3-methoxyquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-((3-(2-hydroxyethoxy)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-(2-aminoethoxy)quinoxalin-6-yl)oxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-((3-(2-methoxyethoxy)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-((3-cyanoquinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluorophenyl)-3-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(3-chlorophenyl)-3-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluorophenyl)-3-(4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluorophenyl)-3-(4-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluorophenyl)-3-(4-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-(1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-((3-(4-methyl-1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-((3-(5-methyl-1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-(1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-((3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-fluorophenyl)-3-(4-((3-(6-(piperazin-1-yl)pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-chlorophenyl)-3-(4-((3-(4-(piperazin-1-yl)phenyl)quinoxalin-6-yl)oxy)phenyl)urea

N-(4-(7-(4-(3-(3-fluorophenyl)ureido)phenoxy)quinoxalin-2-yl)phenyl)methanesulfonamide,

1-(3-fluoro-4-(quinoxalin-6-yloxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-chlorophenyl)-3-(3-fluoro-4-(quinoxalin-6-yloxy)phenyl)urea

1-(3-fluoro-4-(quinoxalin-6-yloxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-4-(quinoxalin-6-yloxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(3-fluoro-4-(quinoxalin-6-yloxy)phenyl)urea

1-(3,5-difluoro-4-(quinoxalin-6-yloxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-chlorophenyl)-3-(3,5-difluoro-4-(quinoxalin-6-yloxy)phenyl)urea

1-(3,5-difluoro-4-(quinoxalin-6-yloxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(3,5-difluoro-4-(quinoxalin-6-yloxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3,5-difluoro-4-(quinoxalin-6-yloxy)phenyl)urea

1-(2-fluoro-4-(quinoxalin-6-yloxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-chlorophenyl)-3-(2-fluoro-4-(quinoxalin-6-yloxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(2-fluoro-4-(quinoxalin-6-yloxy)phenyl)urea

1-(2-fluoro-4-(quinoxalin-6-yloxy)phenyl)-3-(3-fluorophenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-(quinoxalin-6-yloxy)phenyl)urea

1-(3-chlorophenyl)-3-(2,3-difluoro-4-(quinoxalin-6-yloxy)phenyl)urea

1-(2,3-difluoro-4-(quinoxalin-6-yloxy)phenyl)-3-(3-fluorophenyl)urea

1-(2,3-difluoro-4-(quinoxalin-6-yloxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2,3-difluoro-4-(quinoxalin-6-yloxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(2,3-difluoro-4-(quinoxalin-6-yloxy)phenyl)urea

1-(3-fluorophenyl)-3-(2,3,5-trifluoro-4-(quinoxalin-6-yloxy)phenyl)urea

1-(3-chlorophenyl)-3-(2,3,5-trifluoro-4-(quinoxalin-6-yloxy)phenyl)urea

1-(2,3,5-trifluoro-4-(quinoxalin-6-yloxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(2,3,5-trifluoro-4-(quinoxalin-6-yloxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2,3,5-trifluoro-4-(quinoxalin-6-yloxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-4-((3-methoxyquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-4-((3-(2-hydroxyethoxy)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-(2-aminoethoxy)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-4-((3-(2-methoxyethoxy)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-((3-cyanoquinoxalin-6-yl)oxy)-3-fluorophenyl)urea

1-(3-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(2-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(2-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-chlorophenyl)-3-(3-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(3-chlorophenyl)-3-(2-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(3-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(2-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3,5-difluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(3,5-difluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(3,5-difluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3,5-difluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-chlorophenyl)-3-(3,5-difluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(2,3-difluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(2,3-difluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(2,3-difluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-chlorophenyl)-3-(2,3-difluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2,3-difluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(2,3,5-trifluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2,3,5-trifluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(2,3,5-trifluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-fluorophenyl)-3-(2,3,5-trifluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(3-chlorophenyl)-3-(2,3,5-trifluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(2-fluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-chlorophenyl)-3-(2-fluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(2-fluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(2-fluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-fluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-chlorophenyl)-3-(3-fluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(3-fluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(2,3-difluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2,3-difluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-chlorophenyl)-3-(2,3-difluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(2,3-difluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(2,3-difluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3,5-difluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-chlorophenyl)-3-(3,5-difluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3,5-difluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3,5-difluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(3,5-difluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluorophenyl)-3-(2,3,5-trifluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-chlorophenyl)-3-(2,3,5-trifluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(2,3,5-trifluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2,3,5-trifluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(2,3,5-trifluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(2-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(2-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(2-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-chlorophenyl)-3-(2-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(3-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-chlorophenyl)-3-(3-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3,5-difluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(2,3-difluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-chlorophenyl)-3-(2,3-difluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(2,3-difluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluorophenyl)-3-(2,3,5-trifluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-4-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-fluoro-4-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(3-fluoro-4-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-4-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(2-fluoro-4-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(2-fluoro-4-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-fluoro-4-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3,5-difluoro-4-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-fluorophenyl)-3-(2,3,5-trifluoro-4-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3,5-difluoro-4-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-fluorophenyl)-3-(2,3,5-trifluoro-4-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-(1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(3-fluorophenyl)urea

1-(4-((3-(1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-fluoro-4-((3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

3-fluoro-N-(4-(quinoxalin-6-yloxy)phenyl)benzamide

3-chloro-N-(4-(quinoxalin-6-yloxy)phenyl)benzamide

3-chloro-N-(4-(quinoxalin-6-yloxy)phenyl)-4-(trifluoromethyl)benzamide

N-(4-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-3-fluoro-N-(4-(quinoxalin-6-yloxy)phenyl)benzamide

4-chloro-N-(4-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(4-((3-methylquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(4-((3-methoxyquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(4-((3-(2-hydroxyethoxy)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(4-((3-(2-aminoethoxy)quinoxalin-6-yl)oxy)phenyl)-4-chloro-3-(trifluoromethyl)benzamide

4-chloro-N-(4-((3-(2-methoxyethoxy)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(4-((3-cyanoquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-fluoro-N-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

N-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-chloro-N-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-3-fluoro-N-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-chloro-N-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-4-(trifluoromethyl)benzamide

4-chloro-N-(4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-3-fluoro-N-(4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-chloro-N-(4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

3-fluoro-N-(4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-fluoro-N-(4-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(4-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-fluoro-N-(4-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(4-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(4-((3-(1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)-4-chloro-3-(trifluoromethyl)benzamide

4-chloro-N-(4-((3-(4-methyl-1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(4-((3-(5-methyl-1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(4-((3-(1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(4-(3-(1-methyl-1H-pyrazol-4-yl)quinoxaline-6-carbonyl)phenyl)-3-(trifluoromethyl)benzamide

N-(4-(3-(6-(piperazin-1-yl)pyridin-3-yl)quinoxaline-6-carbonyl)phenyl)-3-(trifluoromethyl)benzamide

N-(4-(3-(4-(piperazin-1-yl)phenyl)quinoxaline-6-carbonyl)phenyl)-3-(trifluoromethyl)benzamide

3-fluoro-N-(4-((3-(4-(methylsulfonamido)phenyl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(3-fluoro-4-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

3-fluoro-N-(3-fluoro-4-(quinoxalin-6-yloxy)phenyl)benzamide

3-chloro-N-(3-fluoro-4-(quinoxalin-6-yloxy)phenyl)benzamide

4-chloro-N-(3-fluoro-4-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

3-chloro-N-(2-fluoro-4-(quinoxalin-6-yloxy)phenyl)benzamide

N-(2-fluoro-4-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(2-fluoro-4-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

N-(3,5-difluoro-4-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(3,5-difluoro-4-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

N-(2,3-difluoro-4-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

N-(2,3-difluoro-4-(quinoxalin-6-yloxy)phenyl)-3-fluorobenzamide

4-chloro-N-(2,3-difluoro-4-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

N-(2,3,5-trifluoro-4-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

3-chloro-N-(2,3,5-trifluoro-4-(quinoxalin-6-yloxy)phenyl)benzamide

4-chloro-N-(2,3,5-trifluoro-4-(quinoxalin-6-yloxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(3-fluoro-4-((3-methoxyquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(3-fluoro-4-((3-(2-hydroxyethoxy)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(4-((3-(2-aminoethoxy)quinoxalin-6-yl)oxy)-3-fluorophenyl)-4-chloro-3-(trifluoromethyl)benzamide

4-chloro-N-(3-fluoro-4-((3-(2-methoxyethoxy)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(4-((3-cyanoquinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(trifluoromethyl)benzamide

3-fluoro-N-(3-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

N-(3-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-chloro-N-(3-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(3-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-3-fluoro-N-(3-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

3-fluoro-N-(2-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-3-fluoro-N-(2-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(2-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(2-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-chloro-N-(2-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(3,5-difluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(3,5-difluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

4-chloro-3-fluoro-N-(2,3,5-trifluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

3-fluoro-N-(2,3,5-trifluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(2,3,5-trifluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-chloro-N-(2,3,5-trifluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(2,3-difluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(2,3-difluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

3-chloro-N-(2,3-difluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

N-(2,3-difluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(3-fluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-chloro-N-(3-fluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

3-fluoro-N-(3-fluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(3-fluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-3-fluoro-N-(3-fluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(2-fluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-fluoro-N-(2-fluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

3-chloro-N-(2-fluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-3-fluoro-N-(2-fluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(2-fluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(3,5-difluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

3-fluoro-N-(2,3,5-trifluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

3-chloro-N-(2,3,5-trifluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(2,3-difluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

N-(2,3-difluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-chloro-N-(2,3-difluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(2,3-difluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(2,3-difluoro-4-((3-(pyrrolidin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

4-chloro-N-(3-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-3-fluoro-N-(3-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(3-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-fluoro-N-(3-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

3-chloro-N-(3-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(3,5-difluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(3,5-difluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

N-(3,5-difluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(3,5-difluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

3-chloro-N-(3,5-difluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(2,3,5-trifluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-3-fluoro-N-(2,3,5-trifluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(2,3,5-trifluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3-fluoro-N-(2,3,5-trifluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

3-chloro-N-(2,3,5-trifluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(2,3-difluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(2,3-difluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

N-(2,3-difluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(2,3-difluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

3-chloro-N-(2,3-difluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

3-fluoro-N-(2-fluoro-4-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

3-fluoro-N-(3-fluoro-4-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

3-fluoro-N-(3-fluoro-4-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(3,5-difluoro-4-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

3-fluoro-N-(2,3,5-trifluoro-4-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(2,3-difluoro-4-((3-(6-methylpyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-fluorobenzamide

4-chloro-N-(3-fluoro-4-((3-(pyridin-3-yl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(4-((3-(1H-imidazol-1-yl)quinoxalin-6-yl)oxy)-3-fluorophenyl)-4-chloro-3-(trifluoromethyl)benzamide

4-chloro-3-fluoro-N-(3-fluoro-4-((3-(4-methyl-1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(4-((3-(1H-imidazol-1-yl)quinoxalin-6-yl)oxy)-2-fluorophenyl)-4-chloro-3-(trifluoromethyl)benzamide

4-chloro-3-fluoro-N-(2-fluoro-4-((3-(4-methyl-1H-imidazol-1-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(4-((3-(1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(trifluoromethyl)benzamide

N-(4-((3-(1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)-2-fluorophenyl)-3-(trifluoromethyl)benzamide

N-(4-((3-(1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)-2-fluorophenyl)-3-fluorobenzamide

N-(4-((3-(1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)-2,3-difluorophenyl)-3-fluorobenzamide

N-(4-((3-(1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)-2,3-difluorophenyl)-3-(trifluoromethyl)benzamide

3-fluoro-N-(3-fluoro-4-((3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)oxy)phenyl)benzamide

1-(4-chlorophenyl)-3-(4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-methoxyphenyl)-3-(4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(4-(trifluoromethyl)phenyl)urea

1-(4-cyanophenyl)-3-(4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluorophenyl)-3-(4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-cyano-3-fluorophenyl)-3-(4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-chlorophenyl)-3-(4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluorophenyl)-3-(4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-chloro-4-cyanophenyl)-3-(4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3,4-dichlorophenyl)-3-(4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-chloro-4-fluorophenyl)-3-(4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3,4-difluorophenyl)-3-(4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-(1H-pyrazol-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

1-(4-((3-(1H-pyrazol-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3,4-difluorophenyl)urea

1-(4-chlorophenyl)-3-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(4-(trifluoromethyl)phenyl)urea

1-(4-cyanophenyl)-3-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-cyano-3-fluorophenyl)-3-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(3-chloro-4-cyanophenyl)-3-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(3,4-dichlorophenyl)-3-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-methoxyphenyl)-3-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluorophenyl)-3-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(4-((3-methoxyquinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-methoxyquinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-cyanophenyl)-3-(4-((3-methoxyquinoxalin-6-yl)oxy)phenyl)urea

1-(3-chlorophenyl)-3-(4-((3-methoxyquinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluorophenyl)-3-(4-((3-methoxyquinoxalin-6-yl)oxy)phenyl)urea

1-(3,4-difluorophenyl)-3-(4-((3-methoxyquinoxalin-6-yl)oxy)phenyl)urea

1-(4-methoxyphenyl)-3-(4-((3-methoxyquinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-methoxyquinoxalin-6-yl)oxy)phenyl)-3-(4-(trifluoromethyl)phenyl)urea

1-(4-((3-(aminomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea

1-(4-((3-(aminomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-((3-(aminomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(4-cyanophenyl)urea

1-(4-((3-(aminomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(3-chlorophenyl)urea

1-(4-((3-(aminomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(4-((3-(aminomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(4-methoxyphenyl)urea

1-(4-((3-(aminomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(4-(trifluoromethyl)phenyl)urea

1-(4-((3-(aminomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(3,4-difluorophenyl)urea

1-(4-((3-(aminomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(4-chloro-3-fluorophenyl)urea

1-(4-((3-(aminomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(4-((3-methylquinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-methylquinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-cyanophenyl)-3-(4-((3-methylquinoxalin-6-yl)oxy)phenyl)urea

1-(3-chlorophenyl)-3-(4-((3-methylquinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluorophenyl)-3-(4-((3-methylquinoxalin-6-yl)oxy)phenyl)urea

1-(4-methoxyphenyl)-3-(4-((3-methylquinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-methylquinoxalin-6-yl)oxy)phenyl)-3-(4-(trifluoromethyl)phenyl)urea

1-(3,4-difluorophenyl)-3-(4-((3-methylquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(4-((3-methylquinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-((2-aminoethyl)amino)quinoxalin-6-yl)oxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

1-(4-((3-((2-aminoethyl)amino)quinoxalin-6-yl)oxy)phenyl)-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea

1-(4-((3-((2-aminoethyl)amino)quinoxalin-6-yl)oxy)phenyl)-3-(3,4-difluorophenyl)urea

1-(4-((3-((2-aminoethyl)amino)quinoxalin-6-yl)oxy)phenyl)-3-(4-fluorophenyl)urea

1-(4-((3-((2-aminoethyl)amino)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(4-((3-((2-aminoethyl)amino)quinoxalin-6-yl)oxy)phenyl)-3-(3-chloro-4-fluorophenyl)urea

1-(4-((3-((2-aminoethyl)amino)quinoxalin-6-yl)oxy)phenyl)-3-(4-chloro-3-fluorophenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-((3-((2-hydroxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(4-((3-((2-hydroxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)urea

1-(3,4-difluorophenyl)-3-(4-((3-((2-hydroxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluorophenyl)-3-(4-((3-((2-hydroxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluorophenyl)-3-(4-((3-((2-hydroxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-chloro-4-fluorophenyl)-3-(4-((3-((2-hydroxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(4-((3-((2-hydroxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-((dimethylamino)methyl)quinoxalin-6-yl)oxy)phenyl)-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea

1-(4-((3-((dimethylamino)methyl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-cyanophenyl)-3-(4-((3-((dimethylamino)methyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-chlorophenyl)-3-(4-((3-((dimethylamino)methyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-((dimethylamino)methyl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(4-((3-((dimethylamino)methyl)quinoxalin-6-yl)oxy)phenyl)-3-(4-methoxyphenyl)urea

1-(4-((3-((dimethylamino)methyl)quinoxalin-6-yl)oxy)phenyl)-3-(4-(trifluoromethyl)phenyl)urea

1-(3,4-difluorophenyl)-3-(4-((3-((dimethylamino)methyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(4-((3-((dimethylamino)methyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-((3-((dimethylamino)methyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(4-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-cyanophenyl)-3-(4-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-chlorophenyl)-3-(4-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluorophenyl)-3-(4-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-methoxyphenyl)-3-(4-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)-3-(4-(trifluoromethyl)phenyl)urea

1-(3,4-difluorophenyl)-3-(4-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(4-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-cyanophenyl)-3-(4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-chlorophenyl)-3-(4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluorophenyl)-3-(4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-methoxyphenyl)-3-(4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(4-(trifluoromethyl)phenyl)urea

1-(3,4-difluorophenyl)-3-(4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-((3-(pyrrolidin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-((3-((4-methylpiperazin-1-yl)methyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-(4-methylpiperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-((3-(4-methylpiperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-(3-morpholinopropoxy)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-((3-(2-morpholinoethoxy)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chlorophenyl)-3-(3-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(4-methoxyphenyl)urea

1-(3-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(4-(trifluoromethyl)phenyl)urea

1-(4-cyanophenyl)-3-(3-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(4-fluorophenyl)urea

1-(4-cyano-3-fluorophenyl)-3-(3-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-chloro-4-cyanophenyl)-3-(3-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-cyano-3-(trifluoromethyl)phenyl)-3-(3-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3,4-dichlorophenyl)-3-(3-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-chloro-4-fluorophenyl)-3-(3-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3,4-difluorophenyl)-3-(3-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-4-((3-(piperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-(1H-pyrazol-1-yl)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

1-(4-((3-(1H-pyrazol-1-yl)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(3,4-difluorophenyl)urea

1-(4-chlorophenyl)-3-(3-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(4-(trifluoromethyl)phenyl)urea

1-(4-cyanophenyl)-3-(3-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-cyano-3-fluorophenyl)-3-(3-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(3-chloro-4-cyanophenyl)-3-(3-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(4-cyano-3-(trifluoromethyl)phenyl)-3-(3-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(3,4-dichlorophenyl)-3-(3-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(4-methoxyphenyl)urea

1-(3-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(4-fluorophenyl)urea

1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-4-((3-methoxyquinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-4-((3-methoxyquinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-cyanophenyl)-3-(3-fluoro-4-((3-methoxyquinoxalin-6-yl)oxy)phenyl)urea

1-(3-chlorophenyl)-3-(3-fluoro-4-((3-methoxyquinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-4-((3-methoxyquinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3,4-difluorophenyl)-3-(3-fluoro-4-((3-methoxyquinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-4-((3-methoxyquinoxalin-6-yl)oxy)phenyl)-3-(4-methoxyphenyl)urea

1-(3-fluoro-4-((3-methoxyquinoxalin-6-yl)oxy)phenyl)-3-(4-(trifluoromethyl)phenyl)urea

1-(4-((3-(aminomethyl)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea

1-(4-((3-(aminomethyl)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-((3-(aminomethyl)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(4-cyanophenyl)urea

1-(4-((3-(aminomethyl)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(3-chlorophenyl)urea

1-(4-((3-(aminomethyl)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(3-fluorophenyl)urea

1-(4-((3-(aminomethyl)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(4-methoxyphenyl)urea

1-(4-((3-(aminomethyl)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(4-(trifluoromethyl)phenyl)urea

1-(4-((3-(aminomethyl)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(3,4-difluorophenyl)urea

1-(4-((3-(aminomethyl)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(4-chloro-3-fluorophenyl)urea

1-(4-((3-(aminomethyl)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-4-((3-methylquinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-4-((3-methylquinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-cyanophenyl)-3-(3-fluoro-4-((3-methylquinoxalin-6-yl)oxy)phenyl)urea

1-(3-chlorophenyl)-3-(3-fluoro-4-((3-methylquinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-4-((3-methylquinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-fluoro-4-((3-methylquinoxalin-6-yl)oxy)phenyl)-3-(4-methoxyphenyl)urea

1-(3-fluoro-4-((3-methylquinoxalin-6-yl)oxy)phenyl)-3-(4-(trifluoromethyl)phenyl)urea

1-(3,4-difluorophenyl)-3-(3-fluoro-4-((3-methylquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(3-fluoro-4-((3-methylquinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-4-((3-methylquinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-((2-aminoethyl)amino)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

1-(4-((3-((2-aminoethyl)amino)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea

1-(4-((3-((2-aminoethyl)amino)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(3,4-difluorophenyl)urea

1-(4-((3-((2-aminoethyl)amino)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(4-fluorophenyl)urea

1-(4-((3-((2-aminoethyl)amino)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(3-fluorophenyl)urea

1-(4-((3-((2-aminoethyl)amino)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(3-chloro-4-fluorophenyl)urea

1-(4-((3-((2-aminoethyl)amino)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(4-chloro-3-fluorophenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-4-((3-((2-hydroxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-4-((3-((2-hydroxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)urea

1-(3,4-difluorophenyl)-3-(3-fluoro-4-((3-((2-hydroxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-4-((3-((2-hydroxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)-3-(4-fluorophenyl)urea

1-(3-fluoro-4-((3-((2-hydroxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-chloro-4-fluorophenyl)-3-(3-fluoro-4-((3-((2-hydroxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(3-fluoro-4-((3-((2-hydroxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-((3-((dimethylamino)methyl)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea

1-(4-((3-((dimethylamino)methyl)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-cyanophenyl)-3-(4-((3-((dimethylamino)methyl)quinoxalin-6-yl)oxy)-3-fluorophenyl)urea

1-(3-chlorophenyl)-3-(4-((3-((dimethylamino)methyl)quinoxalin-6-yl)oxy)-3-fluorophenyl)urea

1-(4-((3-((dimethylamino)methyl)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(3-fluorophenyl)urea

1-(4-((3-((dimethylamino)methyl)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(4-methoxyphenyl)urea

1-(4-((3-((dimethylamino)methyl)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3-(4-(trifluoromethyl)phenyl)urea

1-(3,4-difluorophenyl)-3-(4-((3-((dimethylamino)methyl)quinoxalin-6-yl)oxy)-3-fluorophenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(4-((3-((dimethylamino)methyl)quinoxalin-6-yl)oxy)-3-fluorophenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-((3-((dimethylamino)methyl)quinoxalin-6-yl)oxy)-3-fluorophenyl)urea

1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-4-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-4-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-cyanophenyl)-3-(3-fluoro-4-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-chlorophenyl)-3-(3-fluoro-4-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-4-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-fluoro-4-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)-3-(4-methoxyphenyl)urea

1-(3-fluoro-4-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)-3-(4-(trifluoromethyl)phenyl)urea

1-(3,4-difluorophenyl)-3-(3-fluoro-4-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(3-fluoro-4-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-4-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-cyanophenyl)-3-(3-fluoro-4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-chlorophenyl)-3-(3-fluoro-4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(3-fluorophenyl)urea

1-(3-fluoro-4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(4-methoxyphenyl)urea

1-(3-fluoro-4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(4-(trifluoromethyl)phenyl)urea

1-(3,4-difluorophenyl)-3-(3-fluoro-4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-fluorophenyl)-3-(3-fluoro-4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-4-((3-(pyrrolidin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-4-((3-(4-methylpiperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-fluoro-4-((3-(4-methylpiperazin-1-yl)quinoxalin-6-yl)oxy)phenyl)urea

1-(3-fluoro-4-((3-(3-morpholinopropoxy)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

1-(3-fluoro-4-((3-(2-morpholinoethoxy)quinoxalin-6-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

N-(4-((3-(1H-pyrazol-1-yl)quinoxalin-6-yl)oxy)phenyl)-4-chloro-3-(trifluoromethyl)benzamide

3,4-difluoro-N-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

4-fluoro-N-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-cyano-N-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

4-methoxy-N-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

N-(4-((3-(aminomethyl)quinoxalin-6-yl)oxy)phenyl)-3,4-difluorobenzamide

3,4-difluoro-N-(4-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(4-((3-((2-aminoethyl)amino)quinoxalin-6-yl)oxy)phenyl)-4-chloro-3-(trifluoromethyl)benzamide

4-chloro-N-(4-((3-((2-hydroxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3,4-difluoro-N-(4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-fluoro-N-(4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-3-fluoro-N-(4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(4-((3-(pyrrolidin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(4-((3-(1H-pyrazol-1-yl)quinoxalin-6-yl)oxy)-3-fluorophenyl)-4-chloro-3-(trifluoromethyl)benzamide

3,4-difluoro-N-(3-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

4-fluoro-N-(3-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-cyano-N-(3-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)benzamide

N-(3-fluoro-4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)-4-methoxybenzamide

N-(4-((3-(aminomethyl)quinoxalin-6-yl)oxy)-3-fluorophenyl)-3,4-difluorobenzamide

3,4-difluoro-N-(3-fluoro-4-((3-(piperazin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)benzamide

N-(4-((3-((2-aminoethyl)amino)quinoxalin-6-yl)oxy)-3-fluorophenyl)-4-chloro-3-(trifluoromethyl)benzamide

4-chloro-N-(3-fluoro-4-((3-((2-hydroxyethyl)amino)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

3,4-difluoro-N-(3-fluoro-4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-fluoro-N-(3-fluoro-4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-N-(3-fluoro-4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(3-fluoro-4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

4-chloro-3-fluoro-N-(3-fluoro-4-((3-(morpholinomethyl)quinoxalin-6-yl)oxy)phenyl)benzamide

4-chloro-N-(3-fluoro-4-((3-(pyrrolidin-1-ylmethyl)quinoxalin-6-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

N-(4-(quinoxalin-6-yloxy)phenyl)propane-1-sulfonamide

1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(4-((3-morpholinoquinoxalin-6-yl)oxy)phenyl)urea

1-(2-fluoro-4-(quinoxalin-6-yloxy)phenyl)-3-(4-fluorophenyl)urea

1-(4-chlorophenyl)-3-(2-fluoro-4-(quinoxalin-6-yloxy)phenyl)urea

1-(2-fluoro-4-(quinoxalin-6-yloxy)phenyl)-3-(4-(trifluoromethyl)phenyl)urea

1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-(quinoxalin-6-yloxy)phenyl)urea

N-(2-fluoro-4-(quinoxalin-6-yloxy)phenyl)-5-(trifluoromethyl)nicotinamide

N-(2-fluoro-4-(quinoxalin-6-yloxy)phenyl)-2-(trifluoromethyl)isonicotinamide

1-(4-chlorophenyl)-3-(3-fluoro-4-(quinoxalin-6-yloxy)phenyl)urea

and

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-((3-hydroxyquinoxalin-6-yl)oxy)phenyl)urea and pharmaceutically acceptable salts thereof.