Method for Administering a Medicament to a Fetus

• US 20150057505A1
• Filed: 08/22/2013
• Published: 02/26/2015
• Est. Priority Date: 08/22/2013
• Status: Abandoned Application

• Current Assignee: Elwha LLC (Intellectual Ventures LLC)
• Original Assignee: Elwha LLC (Intellectual Ventures LLC)
• Inventors: Bangera, Mahalaxmi Gita, Hyde, Roderick A.
• Application Number:
  US13/973,706
• Publication Number:
  US 20150057505A1
• Time in Patent Office: Days
• US Class Current: 600/301
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/4362 Assessing foetal parameters
• CPC Class Codes: A61M 2037/0007 having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
• CPC Class Codes: A61M 2210/145 Embryo, fetus
• CPC Class Codes: A61M 2210/1458 Placenta
• CPC Class Codes: A61M 2230/005 Parameter used as control input for the apparatus
• CPC Class Codes: A61M 2230/04 Heartbeat characteristics, e.g. ECG, blood pressure modulation
• CPC Class Codes: A61M 2230/205 partial oxygen pressure (P-O2)
• CPC Class Codes: A61M 2230/42 Rate
• CPC Class Codes: A61M 2230/50 Temperature
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61M 37/0015 by using microneedles

Abstract

Methods are disclosed herein for delivering a medicament to a fetus. The method includes administering the medicament from an injector configured to deliver the medicament across an amniotic membrane to amniotic fluid of the fetus. The method includes administering the medicament from a transmembrane patch placed at an amniotic membrane configured to deliver the medicament across the amniotic membrane to amniotic fluid of the fetus.

Claims

1. A method for delivering a medicament to a fetus comprising:

administering the medicament across an amniotic membrane to amniotic fluid of the fetus from an injector non-invasively positioned to the amniotic fluid.

2. The method of claim 1, comprising administering the medicament from the injector surgically emplaced at an outer wall of the amniotic membrane.

3. The method of claim 2, comprising administering the medicament by one or more of microneedle, microjet, microcapsules, iontophoresis, and sonophoresis.

4. The method of claim 2, comprising laproscopically placing the injector at the outer wall of the amniotic membrane.

5. The method of claim 2, wherein the injector is configured to be placed laproscopically at the outer wall of the amniotic membrane.

6. The method of claim 2, wherein the injector is configured to be placed for one-time delivery.

7. The method of claim 1, placing the injector includes a transmembrane patch at an amniotic membrane and configuring the transmembrane patch to deliver the medicament across the amniotic membrane to the amniotic fluid of the fetus.

8. The method of claim 7, wherein the transmembrane patch is configured to deliver the medicament by one or more of microneedle, microjet, microcapsules, iontophoresis, and sonophoresis.

9. The method of claim 7, wherein the transmembrane patch is configured to deliver the medicament in response to a delivery schedule.

10. The method of claim 7, wherein the transmembrane patch is configured to deliver the medicament in response to an external command.

11. The method of claim 1, comprising placing a sensor configured to sense one or more physiological conditions in proximity to the fetus.

12. The method of claim 11, comprising initiating a signal to control administration of the medicament regulated by a controller in response to the one or more sensed physiological conditions.

13. The method of claim 1, comprising administering the medicament at maternal epithelium by one or more of microjets and microneedles.

14. The method of claim 1, comprising administering the medicament at maternal epithelium by microcapsules.

16. The method of claim 1, wherein the medicament is formulated for the fetal gastrointestinal tract.

17. The method of claim 16, wherein the medicament is formulated for intramembranous fetal transfer.

19. The method of claim 3, comprising formulating the medicament to be embedded in microcapsules for extended release characteristics.

21. The method of claim 7, comprising surgically emplacing the transmembrane patch at the amniotic membrane.

25. The method of claim 7, comprising placing a sensor in proximity to the fetus to detect one or more physiological conditions of the fetus.

26. The method of claim 25, wherein the sensor is incorporated with the transmembrane patch.

27. The method of claim 25, comprising initiating a signal to detect with the sensor an analyte in an amniotic fluid sample.

28. The method of claim 25, comprising initiating a signal to detect the one or more physiological conditions of the fetus by vibrational sensing.

29. The method of claim 25, comprising initiating a signal to detect the one or more physiological conditions of the fetus by electrical sensing.

30. The method of claim 25, comprising initiating a signal to detect the one or more physiological conditions of the fetus by electromagnetic sensing.

31. The method of claim 25, comprising initiating a signal to control administration of the medicament regulated by a controller in response to the one or more sensed physiological condition.

32. The method of claim 7, comprising administering the medicament by one or more of microneedle injection, microjet, microcapsules, iontophoresis, and sonophoresis

33. The method of claim 7, wherein the transmembrane patch is configured to deliver the medicament in response to a delivery schedule.

34. The method of claim 7, wherein the transmembrane patch is configured to deliver the medicament in response to an external command.

38. The method of claim 3, comprising initiating a signal to a controller to inject the microcapsules through an amniotic membrane by a needleless injector utilizing at least one of a microjet, sonophoresis, or iontophoresis.

40. The method of claim 3, comprising initiating a signal to a controller to inject the microcapsules through the amniotic membrane by a needle-based injector non-invasively positioned to the amniotic fluid.

41. The method of claim 40, comprising initiating a signal to a controller to inject the microcapsules transdermally through the maternal skin and through the amniotic membrane by the needle-based injector.

43. The method of claim 3, comprising initiating a signal to a controller to transdermally inject the microcapsules through the amniotic membrane to the amniotic fluid by a needle-based injector.

15. The method of claim 15, comprising administering the medicament at maternal epithelium by one or more of iontophoresis and sonophoresis.

18. (canceled)

20. (canceled)

22. (canceled)

23. (canceled)

24. (canceled)

35. (canceled)

36. (canceled)

37. (canceled)

39. (canceled)

42. (canceled)

44. (canceled)

45. A method for detecting one or more physiological conditions of a fetus comprising:

placing a device including a transmembrane sensor in contact with an outer wall of an amniotic membrane of the fetus; and

initiating a signal to the transmembrane sensor and a controller of the device to detect the one or more physiological conditions of the fetus.

46. The method of claim 45, comprising initiating a signal to the sensor and the controller to detect the one or more physiological conditions by removing an analyte through the amniotic membrane.

47. The method of claim 46, comprising initiating a signal to the sensor and the controller to remove the analyte through the amniotic membrane by microneedle, sonophoresis, or iontophoresis.

48. The method of claim 45, comprising initiating a signal to the sensor and the controller to detect the one or more physiological conditions by sensing vibrations caused by the fetus or surrounding amniotic tissue.

49. The method of claim 45, comprising initiating a signal to the sensor and the controller to detect the one or more physiological conditions by sensing electrical signals from the fetus or surrounding amniotic tissue.

50. The method of claim 45, comprising initiating a signal to the sensor and the controller to detect the one or more physiological conditions by sensing electromagnetic signals from the fetus or surrounding amniotic tissue.

51. The method of claim 45, comprising initiating a signal to the sensor and the controller to detect one or more of pH, temperature, analyte identity, or analyte concentration.

52. The method of claim 45, comprising initiating a signal to the sensor and the controller to wirelessly report the sensed physiological condition to a remote computing device.

53. The method of claim 45, comprising initiating a signal to the sensor and the controller to surgically reseal tissue over the transmembrane sensor in contact with the outer wall of the amniotic membrane.

54. The method of claim 45, comprising initiating a signal to the sensor and the controller to report the sensed physiological condition to a computing device on a predetermined schedule.

55. The method of claim 45, comprising initiating a signal to the sensor and the controller to report the sensed physiological condition to a computing device in response to one or more queries.

56. The method of claim 45, comprising initiating a signal to the sensor and the controller to report the sensed physiological condition to a computing device based on previous measurements of the physiological condition.

57. The method of claim 45, comprising initiating a signal to the controller to administer a medicament across the amniotic membrane from an injector non-invasively positioned to the amniotic fluid in response to measurements of one or more sensed physiological conditions.

58. A method for delivering a medicament to a fetus comprising:

placing a device including a transmembrane sensor in contact with an outer wall of an amniotic membrane of the fetus;

initiating a signal to the transmembrane sensor and a controller of the device to detect one or more physiological conditions of the fetus; and

initiating a signal the device and the controller to administer the medicament across an amniotic membrane to amniotic fluid of the fetus from an injector non-invasively positioned to the amniotic fluid responsive to one or more sensed physiological conditions.