SWEAT SIMULATION, COLLECTING AND SENSING SYSTEMS
First Claim
Patent Images
1. A fluid sample collector comprising an aqueous fluid absorbing member;
- a plurality of discrete fluid transporting paths, each path leading from said absorbing member to a separate collection member;
each path having a separate time dependent flow restrictor, wherein each flow restrictor allows fluid flow into one of said collection members at a different time;
a flow bridge in each of said paths effective to stop fluid flow from one of said absorbing member to a corresponding collection member.
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Abstract
Biological chemicals, potentially found in blood are measured by collecting sweat and determining the concentration or meaning of the selected chemical in sweat. The sweat can be collected using a time based, interval collector and analyzed using an external device. It can also be collected on a one time basis, using a flexible, chemical capacitor, or on a continuous basis using a chemical, field effect transducer.
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Citations
38 Claims
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1. A fluid sample collector comprising an aqueous fluid absorbing member;
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a plurality of discrete fluid transporting paths, each path leading from said absorbing member to a separate collection member; each path having a separate time dependent flow restrictor, wherein each flow restrictor allows fluid flow into one of said collection members at a different time; a flow bridge in each of said paths effective to stop fluid flow from one of said absorbing member to a corresponding collection member. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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- 10. A method of collecting an aqueous sample over time comprising collecting a sample at a central collection member and allowing said sample to flow to a plurality of separate collection members, collecting sample portions in each of said collection members at different times.
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17. A method of determining a concentration of a first chemical in sweat comprising collecting a volume of sweat;
- determining the amount of said first chemical in said volume of sweat without determining the volume of said sweat;
determining the amount of a second chemical in said sweat in said volume of sweat to establish a ratio of said first chemical to said second chemical. - View Dependent Claims (18)
- determining the amount of said first chemical in said volume of sweat without determining the volume of said sweat;
- 19. An apparatus to detect biological chemicals in sweat comprising a reservoir containing a cholinergic agonist adjacent a biological chemical sensor, said sensor having one or more functional groups in an assay region reactive with one or more biological chemicals.
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25. A continuous body chemical monitor comprising;
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a sweat absorption member having a collection portion, a transfer portion and an removal portion, wherein said transport portion has a fluid transport capacity less than said collection portion and less than said removal portion; a sensor on a water impervious base said sensor positioned on said transfer portion. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 38)
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33. A method of measuring biomolecules in sweat comprising positioning a sweat collection pad on the skin of an individual, whereby sweat from said individual is collected by said collection pad;
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directing said sweat through said collection pad along a transport portion adjacent to a biological chemical sensor, measuring biomolecules in said sweat with said electrical sensor; directing said sweat from said collection pad through removal portion away from said electrical sensor and away from said collection pad, whereby additional sweat is collected by said collection pad and said additional sweat is analyzed for said biomarkers by said electrical sensor. - View Dependent Claims (34, 35, 36, 37)
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Specification