FULLY WIRELESS CONTINUOUSLY WEARABLE SENSOR FOR MEASUREMENT OF EYE FLUID

• US 20150057516A1
• Filed: 08/21/2014
• Published: 02/26/2015
• Est. Priority Date: 08/23/2013
• Status: Abandoned Application

• Current Assignee: California Institute of Technology
• Original Assignee: California Institute of Technology
• Inventors: MUJEEB-U-RAHMAN, Muhammad, SCHERER, Axel
• Application Number:
  US14/465,777
• Publication Number:
  US 20150057516A1
• Time in Patent Office: Days
• US Class Current: 600/346
• CPC Class Codes: A61B 2560/0219 of externally powered implanted units
• CPC Class Codes: A61B 3/101 for examining the tear film
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/0531 Measuring skin impedance
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/14507 specially adapted for measuring characteristics of body fluids other than blood devices for taking samples of body liquids A61B10/0045
• CPC Class Codes: A61B 5/14517 for sweat
• CPC Class Codes: A61B 5/6821 Eye
• CPC Class Codes: H05K 1/16 incorporating printed electric components, e.g. printed resistor, capacitor, inductor
• CPC Class Codes: H05K 2201/0108 Transparent
• CPC Class Codes: H05K 2201/10151 Sensor
• CPC Class Codes: H05K 3/0014 Shaping of the substrate, e.g. by moulding
• CPC Class Codes: H05K 3/1216 by screen printing or stencil printing
• CPC Class Codes: H05K 3/146 By vapour deposition

Abstract

Novel methods and systems for monitoring the health of an eye are disclosed. For example, a resonant circuit may be fabricated on a contact lens and this circuit may be coupled to a second circuit having the same resonant current frequency. A change in a property of the eye fluid contacted by the sensor in the contact lens is communicated to an external device and a remedying action is suggested to the wearer.

Claims

1. A resonant sensor comprising:

a first resonant circuit, comprising at least one first resistor, at least one first capacitor and at least one first inductor, wherein the first resonant circuit is configured so that an eye fluid in contact with the resonant sensor will electrically connect at least two points in the first resonant circuit, and a change in at least one property of the eye fluid will effect a change in a resonant behavior of the first resonant circuit.

2. The resonant sensor of claim 1, wherein a shape of the at least one first capacitor, of the at least one first resistor, and/or the at least one first inductor is configured so as to give a desired value of a resonant current frequency.

3. The resonant sensor of claim 1, wherein the at least one first resistor, at least one first capacitor and at least one first inductor are metal traces on a wearable contact lens.

4. The resonant sensor of claim 3, wherein a shape, length and overlap of the metal traces is configured so as to give a desired value for a resonant current frequency of the first resonant circuit.

5. A system comprising the resonant sensor of claim 1, further comprising:

a second resonant circuit, comprising at least one second resistor, at least one second capacitor and at least one second inductor, wherein the at least one second inductor is configured to be electromagnetically coupled to the at least one first inductor, and wherein the first and second resonant circuits have a same resonant current frequency; and

a reader configured to communicate with the second resonant circuit, thereby obtaining a measurement of the change in the resonant current frequency.

6. A system comprising the resonant sensor of claim 4, further comprising:

a second resonant circuit, comprising at least one second resistor, at least one second capacitor and at least one second inductor, wherein the at least one second inductor is configured to be electromagnetically coupled to the at least one first inductor, and wherein the first and second resonant circuits have a same resonant current frequency; and

a reader configured to communicate with the second resonant circuit, thereby obtaining a measurement of the change in the resonant frequency.

7. The resonant sensor of claim 1, wherein the at least one property of an eye fluid is its resistance or conductance.

8. The resonant sensor of claim 1, wherein the at least one property of an eye fluid is a concentration of a biological or chemical agent.

9. The resonant sensor of claim 8, wherein the biological or chemical agent is Anthrax.

10. A method to monitor a health state of an eye, the method comprising:

applying the system of claim 6 to the eye;

measuring the at least one property of the eye fluid;

detecting the change in the resonant current frequency;

relating the change in the resonant frequency to the change in the at least one property of the eye fluid; and

communicating the change in the at least one property of the eye fluid.

11. The method of claim 10, further comprising, based on the communicating, and suggesting a remedying action to a wearer of the wearable contact lens.

12. A method to fabricate the resonant sensor of claim 1, comprising printing a metallic circuit on a flexible biocompatible substrate.

13. A method to fabricate the resonant sensor of claim 1, comprising direct metal coating on a flexible polymer by thin film deposition or thick film deposition.

14. The method of claim 13, wherein the thin film deposition is physical vapor deposition or chemical vapor deposition.

15. The method of claim 13, wherein the thick film deposition is screen printing.

16. The resonant sensor of claim 1, wherein the first resonant circuit is fabricated on a flexible substrate shaped like a contact lens.

17. The method of claim 12, further comprising shaping the flexible biocompatible substrate like a contact lens by thermal processing.

18. The method of claim 17, wherein the thermal processing is hot embossing or vacuum forming.

19. The resonant sensor of claim 16, further comprising a hole in a pupil area to increase transparency.

20. A method to measure sweat on a skin with the resonant sensor of claim 1, comprising configuring the resonant sensor to detect at least one property of sweat.

21. The method of claim 12, further comprising functionalizing the resonant sensor with a hydrogel or a polymer containing a desired chemistry.

22. The method of claim 21, wherein the polymer is an ion-sensitive membrane.