BIOLOGICAL INFORMATION MEASUREMENT DEVICE, AND BIOLOGICAL INFORMATION MEASUREMENT METHOD USING SAME

• US 20150059448A1
• Filed: 04/17/2013
• Published: 03/05/2015
• Est. Priority Date: 04/19/2012
• Status: Active Grant

• Current Assignee: PHC Holdings Corporation
• Original Assignee: Panasonic Healthcare Company Limited (PHC Holdings Corporation)
• Inventors: Shinno, Teppei, Hironaka, Shouko
• Granted Patent: US 9,625,442 B2
• Time in Patent Office: Days
• US Class Current: 73/61.43
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771
• CPC Class Codes: G01N 33/48707 by electrical means G01N33/49, G01N33/493 take precedence
• CPC Class Codes: G01N 33/49 Blood chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80
• CPC Class Codes: G01N 33/50 Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing measuring or testing processes involving enzymes or microorganisms, compositions or test papers therefor; processes for forming such compositions, condition responsive control in microbiological or enzymological processes C12Q
• CPC Class Codes: G01N 33/66 involving blood sugars, e.g. galactose

Abstract

The present invention has an object of improving the measurement accuracy in a biological information measurement device, e.g., for measuring a blood glucose level. The device is configured to be able to change at least one of i) a voltage value to be applied to the second input terminal and the third input terminal (i.e., the blood component measurement counter electrode 7 and the blood component measurement working electrode 6) in the second biological information measurement mode D and ii) a voltage application time during which a voltage is applied to the second input terminal and the third input terminal in the second biological information measurement mode D based on the first biological information in the first biological information measurement mode A. A hematocrit value is measured in the first biological information measurement mode A, and a glucose value is measured based on the hematocrit value in the second biological information measurement mode D.

Claims

1. A biological information measurement device to which a biosensor is to be attached, the biosensor comprising a first electrode, a second electrode, a third electrode, and a reagent portion provided between the second electrode and the third electrode,

the biological information measurement device comprising:

a first input terminal to be connected to the first electrode;

a second input terminal to be connected to the second electrode;

a third input terminal to be connected to the third electrode;

a voltage application portion that applies a voltage to the first input terminal, the second input terminal, and the third input terminal;

a control portion that is connected to the voltage application portion; and

a display portion that is connected to the control portion,

wherein the control portion is configured to perform a first biological information measurement mode in which first biological information is measured based on a current flowing through the first input terminal and a second biological information measurement mode in which second biological information is measured by applying a voltage to the second input terminal and the third input terminal after the first biological information measurement mode,

the display portion is configured to display the second biological information,

the reagent portion includes a reagent that reacts with blood,

the first biological information is a hematocrit value,

when the hematocrit value represents a first hematocrit value, the control portion applies a first voltage to the second input terminal and the third input terminal in the second biological information measurement mode, or applies a voltage to the second input terminal and the third input terminal for a first application time in the second biological information measurement mode,

when the hematocrit value represents a second hematocrit value, the control portion applies a second voltage to the second input terminal and the third input terminal in the second biological information measurement mode, or applies a voltage to the second input terminal and the third input terminal for a second application time in the second biological information measurement mode,

the first hematocrit value is larger than the second hematocrit value,

the first voltage is smaller than the second voltage, and

the second application time is longer than the first application time.

2. The biological information measurement device according to claim 1, wherein a clock is connected to the control portion.

3. The biological information measurement device according to claim 1 or 2, wherein a memory is connected to the control portion, and the memory stores data for setting at least one of a voltage value to be applied to the second input terminal and the third input terminal in the second biological information measurement mode and a voltage application time during which a voltage is applied to the second input terminal and the third input terminal in the second biological information measurement mode.

4. The biological information measurement device according to any one of claims 1 to 3, further comprising:

a determination portion that is connected to the second input terminal and the third input terminal,

wherein the determination portion is connected to the control portion, and compares a current flowing between the second electrode and the third electrode through the second input terminal and the third input terminal with a threshold value.

20. A biological information measurement method using the biological information measurement device according to any one of claims 1 to 4, comprising:

attaching the biosensor to the biological information measurement device, then

placing a drop of a biological sample on the biosensor, and then measuring biological information.

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21. A method for measuring an amount of a component in blood, comprising:

a first biological information measurement step that includes applying a voltage to a first electrode system having a working electrode and a counter electrode in the presence of blood, detecting an oxidation current, and converting a value of the oxidation current to a hematocrit value; and

a second biological information measurement step that includes applying a voltage to a second electrode system having a working electrode and a counter electrode, causing oxidation and reduction of a component in the blood with an oxidoreductase in the presence of a mediator, detecting a resultant oxidation-reduction current by the second electrode system, and converting a value of the oxidation-reduction current to an amount of the component in the blood,

wherein when the hematocrit value represents a first hematocrit value, a first voltage is applied to the second electrode system, or a voltage is applied to the second electrode system for a first application time,

when the hematocrit value represents a second hematocrit value, a second voltage is applied to the second electrode system, or a voltage is applied to the second electrode system for a second application time,

the first hematocrit value is larger than the second hematocrit value,

the first voltage is smaller than the second voltage, and

the second application time is longer than the first application time.

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