CIRCADIAN RHYTHM-IMPROVING AGENT

• US 20150064151A1
• Filed: 02/08/2013
• Published: 03/05/2015
• Est. Priority Date: 03/02/2012
• Status: Active Grant

• Current Assignee: National Institute of Advanced Industrial Science and Technology (Government of Japan), Sapporo Breweries Limited (Sapporo Holdings Limited)
• Original Assignee: National Institute of Advanced Industrial Science and Technology (Government of Japan), Sapporo Holdings Limited
• Inventors: Ooishi, Katsutaka, Miyazaki, Koyomi, Itoh, Nanako, Yamamoto, Saori, Nakakita, Yasukazu, Kaneda, Hirotaka
• Granted Patent: US 10,695,383 B2
• Time in Patent Office: Days
• US Class Current: 424/93.45
• CPC Class Codes: A23L 2/382 fermented fermented nut meats or seeds A23L25/40; fermented milk preparations A23C9/12; addition of bacteria for nutritional purposes A23L33/135
• CPC Class Codes: A23L 2/52 Adding ingredients adding preservatives A23L2/44
• CPC Class Codes: A23L 33/135 Bacteria or derivatives thereof, e.g. probiotics
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2400/121 Brevis
• CPC Class Codes: A61K 35/74 Bacteria therapeutic use of a bacterial protein A61K38/00
• CPC Class Codes: A61K 35/744 Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/20 Hypnotics; Sedatives
• CPC Class Codes: A61P 25/26 Psychostimulants, e.g. nicotine, cocaine

Abstract

The invention provides an agent for improving circadian rhythm comprising cells of lactic acid bacterium or treated product thereof as an active ingredient.

Claims

1-10. -10. (canceled)

11. A method for improving circadian rhythm in a subject in need thereof, said method comprising administering to the subject an agent comprising cells of a lactic acid bacterium or a treated product thereof as an active ingredient.

12. The method according to claim 11, wherein the lactic acid bacterium belongs to Lactobacillus brevis.

13. The method according to claim 11, wherein the lactic acid bacterium is Lactobacillus brevis SBC8803 (deposit number:

FERM BP-10632).

14. The method according to claim 11, wherein improvement of circadian rhythm is based on normalization of a mRNA expression level of a clock gene.

15. The method according to claim 14, wherein the clock gene is Per2 or Bma11.

16. The method according to claim 11, wherein the method is for improvement of circadian rhythm sleep disorder.

17. The method according to claim 11, wherein the at least one cell is administered in a pharmaceutical product.

18. The method according to claim 11, wherein the at least one cell is administered in a food or beverage.

19. The method according to claim 11, wherein the at least one cell is administered in a food or beverage additive.

20. The method according to claim 11, wherein an agent comprising cells of a lactic acid bacterium is administered to a subject in need thereof.

21. The method according to claim 11, wherein a treated product comprising the cells of a lactic acid bacterium is administered to a subject in need thereof.