DOUBLE-CHAMBER MIXING SYRINGE AND METHOD OF USE

• US 20150065993A1
• Filed: 09/03/2014
• Published: 03/05/2015
• Est. Priority Date: 09/03/2013
• Status: Active Grant

• Current Assignee: Pharma PHD II, LLC
• Original Assignee: Max Arocha
• Inventors: Arocha, Max
• Granted Patent: US 10,420,888 B2
• Time in Patent Office: Days
• US Class Current: 604/506
• CPC Class Codes: A61M 2205/583 by visual feedback
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: A61M 5/2466 by piercing without internal pressure increase A61M5/2429 takes precedence
• CPC Class Codes: A61M 5/31551 including axial movement of dose setting member
• CPC Class Codes: A61M 5/31563 interacting with a displaceable stop member
• CPC Class Codes: A61M 5/3158 performed by axially moving actuator operated by user, e.g. an injection button

Abstract

Described is a syringe housing at least one removable carpule containing at least two injectable solutions and having a mixing chamber for mixing two injectable solutions during administration of the solutions, and methods of using the syringe.

Claims

1. A syringe comprising:

a syringe housing forming a hollow syringe body or syringe barrel bounding a syringe chamber, said syringe body or barrel being adapted for receiving within the chamber at least one carpule having multiple chambers or at least two single-chambered carpules, each chamber containing an injectable drug composition or diluent for the drug composition,

a dual-stemmed syringe plunger having a superior and inferior end, wherein the inferior end of each stem slidingly engages with a sliding plug at a superior end of the carpule containing an injectable fluid, said carpule further comprising a sealed or capped inferior end

a carpule-piercing means for engaging with and piercing or puncturing the inferior capped or sealed end of the carpule when pressure is applied by the plunger, said carpule piercing means being superior to and in communication with

a mixing chamber for receiving and adequately mixing the fluids dispensed from the pierced carpules, and

an exit port or nozzle for dispensing from the mixing chamber the mixed injectable drug and second injectable fluid, whereby, depressing or actuating the plunger causes piercing of the at least one carpule to deliver a predetermined amount or volume of drug and second injectable fluid to the mixing chamber for mixing during administration of the mixed injectable drug and second injectable fluid through the exit port or nozzle.

2. The syringe of claim 1 wherein the exit port or nozzle is configured to receive a disposable needle.

3. The device of claim 1 wherein the mixing chamber further comprises a turbulence-causing structure.

4. The device of claim 1 wherein the dual-stemmed plunger comprises at least one fixed-length stem.

5. The device of claim 1 wherein the dual stemmed plunger comprises at least one adjustable-length stem.

6. The device of claim 1 wherein the syringe barrel is adapted to receive a multi-chambered carpule.

7. The device of claim 1 wherein the syringe barrel is adapted to receive at least two single-chambered carpules.

14. A system for mixing two injectable compositions from a single actuation of a syringe plunger, and delivering said mixed compositions simultaneously to a patient in need thereof, said system comprising,

a) a syringe of claim 1;

and

b) at least two single-chambered carpules or at least one multi-chambered carpule, each chamber of said carpule containing an injectable composition.

15. The system of claim 14, wherein the carpule is a multi-chambered carpule comprising two single-chambered carpules affixed together to form a single unit.

8. A carpule comprising at least two chambers for containing an injectable composition.

9. The carpule of claim 8, wherein the carpule contains a drug composition in one chamber and a diluent in a second chamber.

10. The carpule of claim 8 wherein the carpule contains a drug composition in one chamber and a second drug composition in a second chamber.

11. The carpule of claim 8 wherein the carpule comprises two single-chambered carpules affixed together.

12. A method for mixing an injectable drug composition and a second composition selected from a diluent, buffer, and second injectable drug composition, and administering the mixed drug and second composition using a single actuation of a syringe plunger, said method comprises the steps of:

a) providing a syringe having a double-chambered barrel capable of receiving two carpules, a dual-stemmed plunger, and mixing chamber, as described herein;

b) loading at least one carpule containing a drug or drug solution into a first chamber of a double-chambered syringe barrel or body;

c) loading a second carpule containing a diluent, buffer, or second drug solution into a second chamber of a double-chambered syringe barrel or body;

d) checking calibration for accurate and precise amounts or volumes of solution from each respective carpule, and optionally adjusting said calibration as desired; and

e) actuating the plunger to concurrently deliver the solutions from each carpule into the mixing chamber, and subsequently administer the mixed solutions into a target tissue.

13. The method of claim 12 wherein the mixing chamber comprises a turbulence-causing or turbulence-forming structure to turbulently mix the compositions entering the mixing chamber.