DETECTING, QUANTIFYING, AND/OR CLASSIFYING SEIZURES USING MULTIMODAL DATA
First Claim
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1. A method for detecting an epileptic event based upon a patient'"'"'s cardiac signal and kinetic activity, comprising:
- providing a cardiac signal indicative of the patient'"'"'s heart beats;
providing a kinetic signal indicative of a body movement of the patient; and
detecting an epileptic event based upon the cardiac signal and the kinetic signal.
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Abstract
Methods, systems, and apparatus for detecting an epileptic event, for example, a seizure in a patient using a medical device. The determination is performed by providing an autonomic signal indicative of the patient'"'"'s autonomic activity; providing a neurologic signal indicative of the patient'"'"'s neurological activity; and detecting an epileptic event based upon the autonomic signal and the neurologic signal.
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Citations
31 Claims
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1. A method for detecting an epileptic event based upon a patient'"'"'s cardiac signal and kinetic activity, comprising:
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providing a cardiac signal indicative of the patient'"'"'s heart beats; providing a kinetic signal indicative of a body movement of the patient; and detecting an epileptic event based upon the cardiac signal and the kinetic signal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A computer readable program storage device encoded with instructions that, when executed by a computer, performs a method for detecting an epileptic seizure based upon a patient'"'"'s cardiac signal and kinetic activity, comprising:
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providing a kinetic signal indicative of a body movement of the patient; calculating at least one kinetic score for said kinetic signal, said at least one kinetic score being indicative of a correlation of said kinetic signal with an epileptic seizure; providing a cardiac signal indicative of a heart beat sequence for said patient; detecting a possible epileptic seizure based upon the patient'"'"'s heart beat sequence; and providing an output indicative of an epileptic seizure if the kinetic score exceeds a first correlation reference value for an epileptic seizure. - View Dependent Claims (13)
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14. A computer readable program storage device encoded with instructions that, when executed by a computer, performs a method for detecting an epileptic event based upon a patient'"'"'s cardiac signal and kinetic activity, comprising:
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providing a kinetic signal indicative of a body movement of the patient; calculating based on the kinetic signal a kinetic score indicative of a correlation of said kinetic signal with an epileptic event; detecting an epileptic event based upon changes in the patient'"'"'s cardiac signal; confirming the detecting if said kinetic score reflects a high correlation with an epileptic event; overriding the detecting if said kinetic score reflects a low correlation with an epileptic event; and providing an output indicative of an epileptic event only if the detecting is confirmed.
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15. A method for detecting a generalized tonic-clonic epileptic seizure based upon two or more of a patient'"'"'s body signals, comprising:
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providing a cardiac signal indicative of the patient'"'"'s heart beat sequence and an accelerometer signal indicative of the patient'"'"'s movement; and detecting a generalized tonic-clonic epileptic seizure based upon the timewise correlation of at least one feature of the cardiac signal and at least one feature of the accelerometer signal, wherein; the at least one feature of the cardiac signal is a heart rate above an interictal reference value; and the at least one feature of the accelerometer signal is an indication of a clonic movement followed by an indication of a cessation of said clonic movement. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22)
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23. A computer readable program storage device encoded with instructions that, when executed by a computer, performs a method for detecting a partial epileptic seizure based upon two or more of a patient'"'"'s body signals, comprising:
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providing a cardiac signal indicative of the patient'"'"'s heart beat sequence; and
an accelerometer signal indicative of the patient'"'"'s movement; anddetecting the partial epileptic seizure based upon the timewise correlation of at least a first feature of said cardiac signal and at least a first feature of said accelerometer signal, wherein; the first feature of the cardiac signal is a heart rate outside an interictal reference value range; and the first feature of the accelerometer signal is a characteristic of movement outside an interictal reference value range and is not a generalized clonic movement. - View Dependent Claims (24, 25, 26, 27, 28, 29)
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30. A medical device system for detecting an epileptic event based upon multimodal signals, comprising:
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a first sensor for detecting a first modal data and a second sensor for detecting a second modal data relating to a patient'"'"'s body, the first modal data comprising a kinetic signal and the second modal data comprising a cardiac signal of the patient'"'"'s body; and an implantable medical device (IMD) operatively coupled to the first sensor and the second sensor;
the IMD comprising;a kinetic signal module for receiving the kinetic signal; a cardiac signal module for receiving the cardiac signal; and a processing element for determining whether an epileptic event has occurred based upon the first and second modal data.
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31. A computer readable program storage device encoded with instructions that, when executed by a computer, performs a method for detecting an epileptic seizure based upon two or more of a patient'"'"'s body signals, comprising:
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providing a responsiveness signal indicative of the patient'"'"'s responsiveness; detecting a seizure if there is a decrease in the patient'"'"'s responsiveness below a reference value that is timewise correlated with a feature of a cardiac signal, classifying the seizure as a generalized tonic-clonic seizure if the accelerometer signal is indicative of
1) a loss of postural muscle tone outside an inter-ictal reference value,
2) in increase in postural muscle tone outside an inter-ictal range of reference value, or
3) a fall, correlated with the feature of the cardiac signalclassifying the seizure as a partial seizure if a decrease in the patient'"'"'s responsiveness is not associated with a change in the accelerometer signal indicative of a loss of postural muscle tone outside an inter-ictal reference value, an increase in postural muscle tone outside an inter-ictal reference value, or if a fall is observed; classifying the seizure as a partial simple if a decrease in responsiveness is not correlated with a decrease in awareness below an inter-ictal reference value; and classifying the seizure as a complex partial seizure if a decrease in responsiveness is associated with a decrease in awareness below an inter-ictal reference value.
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Specification