System And Method For Improved Determination Of A Brain Response State

• US 20150073293A1
• Filed: 03/05/2013
• Published: 03/12/2015
• Est. Priority Date: 03/05/2012
• Status: Active Grant

• Current Assignee: SensoDetect AB
• Original Assignee: SensoDetect AB
• Inventors: Kllstrand, Johan
• Granted Patent: US 10,098,562 B2
• Time in Patent Office: Days
• US Class Current: 600/544
• CPC Class Codes: A61B 5/165 Evaluating the state of mind, e.g. depression, anxiety
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/38 Acoustic or auditory stimuli
• CPC Class Codes: A61B 5/4088 Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
• CPC Class Codes: A61B 5/4848 Monitoring or testing the effects of treatment, e.g. of medication

Abstract

A device and a method for detecting a brain response state of a subject id disclosed. The detection comprises repeatedly presenting the subject with a sound stimulus for evoking a brain response. Detecting the evoked brain response signal related to each of said sound stimulus. Determining a window having a time width covering at least partly an area of at least one neuron'"'"'s evoked response in the brain response signal. Calculating an average response signal over the window and comparing the at least one neuron'"'"'s evoked response with the average response signal for determining a cellular variance and/or volatility.

Claims

1. A method for detecting a brain response state of a subject, wherein said method comprising:

repeatedly presenting said subject with a sound stimulus for evoking a brain response;

detecting an evoked brain response signal related to each of said sound stimulus, wherein said evoked brain response signal is an electrophysiological signal and said evoked brain response signal comprises at least one peak related to an evoked response of at least one neuron;

determining a time window, said time window has a time width covering at least partly one of said at least one peak in said evoked brain response signal;

calculating an average evoked response signal based on said evoked brain response signals over said time window;

or calculating an average value based on one of said evoked brain response signal over said time window;

comparing said evoked brain response signals over said time window with said average evoked response signal;

or comparing subparts of said evoked brain response signal over said time window with said average value; and

determining a variance and/or volatility of at Least one neuron'"'"'s evoked response based on said comparison.

2. The method according to claim 1, wherein said cellular variance and/or volatility is determined based on difference in amplitude.

3. The method according to claim 1, wherein said cellular variance and/or volatility is determined based on difference in latency.

4. The method according to claim 1, wherein calculating said average is based on using a subseries of said evoked brain response signals.

5. The method according to claim 1, wherein said sound stimulus comprising a first and at least a second consecutive train of modified sounds pulses for evoking a first response signal by said first train of sound pulses and for evoking a second response signal by said second train of modified sound pulses.

6. The method according to claim 1, wherein said evoked brain response signal is an evoked brainstem response signal.

7. The method according to claim 1, wherein said method is used for determining a brain disorder.

8. The method according to claim 1, wherein said method is used for detecting an effect of a substance or compound on the brain of a subject.

9. The method according to claim 8, wherein said effect is detectable in real-time.

10. A device for detecting a brain response state of a subject, comprising:

a sound stimuli generating unit operative to repeatedly present said subject with a sound stimulus for evoking a brain response;

a detection unit operative to detect an evoked brain response signal related to each of said sound stimulus, wherein said evoked brain response signal is an electrophysiological signal and said evoked brain response signal comprises at least one peak related to an evoked response of at least one neuron;

a storage unit operative to store information based on said evoked brain response signal;

a control unit for determining a time window, said time window has a time width covering at least partly one of said at least one peak in said evoked brain response signal, and for calculating an average evoked response signal based on said evoked brain response signals over said time window or calculating an average value based on one of said evoked brain response signal over said time window, and for comparing said evoked brain response signal over said time window with said average evoked response signal, or comparing subparts of said evoked brain response signal over said time window with said average value, and for determining a variance and/or volatility of at least one neuron'"'"'s evoked response based on said codon comparison.

11. The device according to claim 10, wherein said cellular variance and/or volatility is determined based on difference in amplitude.

12. The device according to claim 10, wherein said cellular variance and/or volatility is determined based on difference in latency.

13. The device according to claim 10, wherein calculating said average is based on a subseries of said evoked brain response signals.

14. The device according to claim 10 wherein said sound stimulus comprising a first and at least a second consecutive train of modified sounds pulses for evoking a first response signal by said first train of sound pulses and for evoking a second response signal by said second train of modified sound pulses.

15. The device according to claim 10, wherein said evoked brain response signal is an evoked brainstem response signal.

16. The device according to claim 10, wherein said cellular variance and/or volatility is used for determining a brain disorder;

and/or an effect of a substance or compound on the brain of a subject.

17. A computer-readable storage medium having Instructions stored thereon that when executed by one or more processors perform operations for detecting a brain response state of a subject, said instructions including:

repeatedly presenting said subject with a sound stimulus for evoking a brain response;

detecting an evoked brain response signal related to each of said sound stimulus, wherein said evoked brain response signal is an electrophysiological signal and said evoked brain response signal comprises at least one peak related to an evoked response of at least one neuron;

determining a time window, said time window has a time width covering at least partly one of said at least one peak in said evoked brain response signal;

calculating an average evoked response signal based on said evoked brain response signals over said time window, or calculating an average value based on one of said evoked brain response signal over said time window;

comparing said evoked brain response signals over said time window with said average evoked response signal, or comparing subparts of said evoked brain response signal over said time window with said average value; and

determining a variance and/or volatility of at least one neuron'"'"'s evoked response based on said comparison.

18. (canceled)