×

Method and Apparatus for Improved Quantitation by Mass Spectrometry

  • US 20150073727A1
  • Filed: 03/28/2013
  • Published: 03/12/2015
  • Est. Priority Date: 04/02/2012
  • Status: Active Grant
First Claim
Patent Images

1. A method of quantifying one or more analytes from mass spectral data, comprising:

  • obtaining a first set of mass spectral data from a first set of analytes eluted from a chromatography column;

    obtaining a second set of mass spectral data from a second set of analytes eluted from a chromatography column;

    wherein a majority of the analytes in each data set are common to both data sets;

    determining apparent abundances of at least some analytes in each data set;

    selecting an analyte as a target analyte and determining for that analyte a plurality of localised neighboring analytes by their locality to the target analyte with respect to retention time;

    determining a locally corrected abundance of the target analyte based on differences between the first and second data sets in the apparent abundance of the determined localised neighboring analytes; and

    quantifying the target analyte based on its corrected abundance.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×