PROBIOTIC BACTERIA

• US 20150079040A1
• Filed: 03/15/2013
• Published: 03/19/2015
• Est. Priority Date: 04/13/2012
• Status: Abandoned Application

• Current Assignee: SkinBioTherapeutics Plc
• Original Assignee: University of Manchester
• Inventors: O'Neill, Catherine, McBain, Andrew
• Application Number:
  US14/394,017
• Publication Number:
  US 20150079040A1
• Time in Patent Office: Days
• US Class Current: 424/93.3
• CPC Class Codes: A01N 63/20 Bacteria; Substances produced thereby or obtained therefrom
• CPC Class Codes: A61K 2035/115 Probiotics
• CPC Class Codes: A61K 2800/70 Biological properties of the composition as a whole
• CPC Class Codes: A61K 35/742 Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
• CPC Class Codes: A61K 35/744 Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
• CPC Class Codes: A61K 35/745 Bifidobacteria
• CPC Class Codes: A61K 35/747 Lactobacilli, e.g. L. acidophilus or L. brevis
• CPC Class Codes: A61K 8/99 from microorganisms other than algae or fungi, e.g. protozoa or bacteria
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 31/10 Antimycotics
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

The invention provides probiotic bacteria and lysates thereof for use in methods of medical and cosmetic treatment. Use in the treatment of infections, including skin infections and methods involving regeneration or repair of the skin barrier are contemplated.

Claims

1. A probiotic bacterium or a lysate thereof for use in a method of treatment, wherein the probiotic bacterium is a strain of Lactobacillus rhamnosus, a strain of Lactobacillus reuteri, or a strain of Bifidobacterium longum.

2. A probiotic bacterium or a lysate thereof for use in a method of treatment according to claim 1, wherein the method of treatment involves repair or regeneration of the skin barrier.

3. A probiotic bacterium or a lysate thereof for use in a method of treatment according to claim 1 or 2, wherein the probiotic bacterium is Lactobacillus rhamnosus GG.

4. A probiotic bacterium or a lysate thereof for use in a method of treatment according to any one of claims 1 to 3, wherein the probiotic bacterium is for use in the repair or regeneration of the skin after injury.

5. A probiotic bacterium or a lysate thereof for use in a method of treatment according to any one of claims 1 to 3, wherein the method is for treatment of wound healing, burns, psoriasis, icthyosis, dermatitis, acne (including Hiradenitis Suppurativa), Diaper Rash, Netherton'"'"'s Syndrome, Actinic Keratosis, Dermatomycoses, Dermatosis, or Ectodermal Dysplasia.

6. A probiotic bacterium or a lysate thereof for use in a method of treatment according to any one of claims 1 to 5, wherein the method of treatment involves administration of the probiotic bacterium or lysate thereof to the skin of the patient being treated.

7. A probiotic bacterium or a lysate thereof for use in a method of treatment according to claim 1, wherein the probiotic bacterium is Lactobacillus rhamnosus GG and the method of treatment involves the treatment or prevention of infection.

8. A probiotic bacterium or a lysate thereof for use in a method of treatment according to claim 7, wherein the infection comprises a bacterial infection.

9. A probiotic bacterium or a lysate thereof for use in a method of treatment according to claim 7 or 8, wherein the bacterial infection is a Staphylococcus infection, preferably a Staphylococcus aureus infection.

10. A probiotic bacterium or a lysate thereof for use in a method of treatment according to any one of claims 7 to 9, wherein the infection is a skin infection.

11. A probiotic bacterium for use according to any one of the preceding claims wherein the probiotic bacterium is co-administered with a probiotic bacterium of a different strain, or a lysate thereof.

12. A probiotic bacterium or a lysate thereof for use in a method of treatment according to any one of the preceding claims wherein the method of treatment involves co-administration of one of a strain of Lactobacillus rhamnosus or a lysate thereof, a strain of Lactobacillus reuteri or a lysate thereof, or a strain of Bifidobacterium longum or a lysate thereof, with at least another one of said strains or lysates.

13. A cosmetic method comprising administration of a strain of Lactobacillus rhamnosus probiotic bacterium or a lysate thereof, and/or a strain of Lactobacillus reuteri probiotic bacterium or a lysate thereof, and/or a strain of Bifidobacterium longum probiotic bacterium or a lysate thereof, to a subject.

14. A cosmetic method according to claim 13, wherein the strain of Lactobacillus rhamnosus probiotic bacterium is Lactobacillus rhamnosus GG.

15. A cosmetic method according to claim 13 or 14, wherein the probiotic bacterium or lysate thereof is administered to the skin of the subject.

16. A cosmetic composition comprising a strain of Lactobacillus rhamnosus probiotic bacterium or a lysate thereof, and/or a strain of Lactobacillus reuteri probiotic bacterium or a lysate thereof and/or a strain of Bifidobacterium longum probiotic bacterium or a lysate thereof.

17. A cosmetic composition according to claim 16, wherein the strain of Lactobacillus rhamnosus probiotic bacterium is Lactobacillus rhamnosus GG.

18. A pharmaceutical composition comprising Lactobacillus rhamnosus GG or a lysate thereof.

19. The pharmaceutical composition according to claim 18 further comprising a probiotic bacterium of a strain other than Lactobacillus rhamnosus, or a lysate thereof, wherein preferably the probiotic bacterium of a strain other than Lactobacillus rhamnosus is a strain of Lactobacillus reuteri.

20. A lysate of Lactobacillus rhamnosus GG.

21. A composition formulated for administration to the skin and comprising Lactobacillus rhamnosus GG, and/or a strain of Lactobacillus rhamnosus and/or a strain of Lactobacillus reuteri, and/or a strain of Bifidobacterium longum or a lysate of one or more of said bacteria.

22. An antibacterial composition comprising Lactobacillus rhamnosus GG or a lysate thereof.