ANTIMICROBIAL ALCOHOL FOAM COMPOSITIONS AND METHODS OF PREPARATION

• US 20150080478A1
• Filed: 03/15/2013
• Published: 03/19/2015
• Est. Priority Date: 03/30/2012
• Status: Active Grant

• Current Assignee: GOJO Industries Incorporated
• Original Assignee: GOJO Industries Incorporated
• Inventors: Cohen, Mitchell Jared, Eberts, James Harvey III, Hillman, Evan David
• Granted Patent: US 9,516,877 B2
• Time in Patent Office: Days
• US Class Current: 514/724
• CPC Class Codes: A01N 25/16 Foams
• CPC Class Codes: A01N 31/02 Acyclic compounds
• CPC Class Codes: A01N 37/02 Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
• CPC Class Codes: A01N 59/00 Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
• CPC Class Codes: A01N 61/00 Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
• CPC Class Codes: A61K 8/046 Aerosols; Foams
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/34 Alcohols
• CPC Class Codes: A61K 8/342 Alcohols having more than seven atoms in an unbroken chain
• CPC Class Codes: A61K 8/365 Hydroxycarboxylic acids; Ketocarboxylic acids
• CPC Class Codes: A61K 8/86 Polyethers
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 31/02 Local antiseptics
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: B05B 7/0018 with devices for making foam
• CPC Class Codes: B05B 7/0408 with arrangements for mixing two or more liquids
• CPC Class Codes: B05B 7/2472 comprising several containers

Abstract

A method for preparing an antimicrobial alcoholic foam composition by combining two or more pre-mix compositions. A first pre-mix composition is primarily alcoholic comprises an alcohol, an acidic component, and a waxy component. A second pre-mix composition is primarily aqueous comprises water and a carbonate. An antimicrobial alcoholic foam composition that does not require added air or aerosol propellant is also provided.

Claims

1. (canceled)

2. A method of preparing an antimicrobial alcoholic foam composition, the method comprising the steps of:

providing a dispenser having a first reservoir containing a first liquid pre-mix that is an aqueous pre-mix, a second reservoir containing a second liquid pre-mix that is an alcoholic pre-mix;

dispensing an aliquot of said aqueous pre-mix, wherein said aqueous pre-mix comprises a carbonate and water;

dispensing an aliquot of said alcoholic pre-mix, wherein said alcoholic pre-mix comprises at least 50 wt. % of a C_1-6 alcohol, based upon the total weight of the alcoholic pre-mix, a waxy component, and an acidic component;

commingling said aliquot of said aqueous pre-mix and said aliquot of said alcoholic pre-mix, whereupon said aliquots of said aqueous pre-mix and said alcoholic pre-mix chemically react and generate an antimicrobial alcoholic foam.

3. The method of claim 2, where the acidic component is selected from the group consisting of hydrochloric acid, nitric acid, phosphoric acid, phosphonic acid, boric acid, sulfuric acid, adipic acid, benzene 1,3,5 tricarboxylic acid, chlorosuccinic acid, choline chloride, cis-aconitic acid, citramalic acid, citric acid, cyclobutane 1,1,3,3 tetracarboxylic acid, cyclohexane 1,2,4,5 tetracarboxylic acid, cyclopentane 1,2,3,4 tetracarboxylic acid, diglycolic acid, fumaric acid, glutamic acid, glutaric acid, glyoxylic acid, isocitric acid, ketomalonic acid, lactic acid, maleic acid, malic acid, malonic acid, nitrilotriacetic acid, oxalacetic acid, oxalic acid, phytic acid, p-toluenesulfonic acid, salicylic acid, succinic acid, tartaric acid, tartronic acid, tetrahydrofuran 2,3,4,5 tetracarboxylic acid, tricarballylic acid, versene acids, 3-hydroxyglutaric acid, 2-hydroxypropane 1,3 dicarboxylic acid, glyceric acid, furan 2,5 dicarboxylic acid, 3,4-dihydroxyfuran-2,5 dicarboxylic acid, 3,4-dihydroxytetrahydrofuran-2,5-dicarboxylic acid, 2-oxo-glutaric acid, dl-glyceric acid, and 2,5 furandicarboxylic acid, tartaric acid, malic acid, gluconic acid, fumaric acid, ascorbic acid, citric acid, isocitric acid, lactic acid, tartronic acid, oxalic acid, salicylic acid, malonic acid, potassium bitartrate, calcium phosphate, sodium aluminum phosphate, sodium aluminum sulfate, monosodium phosphate, disodium pyrophosphate, calcium lactate, calcium sulfate, calcium phosphate, sodium aluminum phosphate, sodium aluminum sulfate, monosodium phosphate and disodium pyrophosphate, and mixtures thereof.

4. The method of claim 2, wherein the acidic component is selected from the group consisting of citric acid, lactic acid, malic acid, tartaric acid, salicylic acid, oxalic acid, and mixtures thereof.

5. The method of claim 2, wherein the acidic component is citric acid.

6. The method of claim 2, wherein the amount of acidic component is at least 0.02 equivalent weights of acid per 100 g of combined aqueous pre-mix and alcoholic pre-mix.

7. The method of claim 2, wherein the amount of acidic component is from 0.5 to about 2 times the number of equivalent weights of carbonate present in the aqueous pre-mix.

8. The method of claim 2, wherein the amount of acidic component is the stoichiometric amount of acid required to produce at least 0.02 moles of carbon dioxide per 100 g of combined aqueous pre-mix and alcoholic pre-mix.

9. The method of claim 2, wherein the carbonate is selected from the group consisting of sodium carbonate, potassium carbonate, lithium carbonate, sodium bicarbonate, potassium bicarbonate, calcium bicarbonate, ammonium bicarbonate, and mixtures thereof.

10. The method of claim 2, wherein the carbonate is potassium bicarbonate.

11. The method of claim 2, wherein the amount of carbonate is an effective amount.

12. The method of claim 2, wherein the amount of carbonate is the stoichiometric amount of carbonate required to yield at least 0.02 moles of carbon dioxide per 100 g of combined aqueous pre-mix and alcoholic pre-mix.

13. The method of claim 2, wherein the aqueous pre-mix is a saturated solution with respect to the carbonate.

14. The method of claim 2, wherein the waxy component is selected from the group consisting of carnauba wax, ouricury wax, Japan wax, cork fiber wax, sugarcane wax, paraffin waxes, lignite waxes, microcrystalline waxes, lanolin wax, ozokerite, polyethylene wax, silicone waxes, plant waxes, C_8-24 fatty alcohols, C_8-24 fatty acids, glycerides that are solid at room temperature, blends of a C_8-24 fatty alcohol with an ethoxylated C_8-24 fatty alcohol, blends of a C_8-24 fatty alcohol and a non-ionic surfactant, and mixtures thereof, with the proviso that the wax is at least sparingly soluble in a lower alcohol at standard temperature and pressure.

15. The method of claim 2, wherein the waxy component is an emulsifying wax.

16. The method of claim 2, wherein the waxy component is present in an amount of at least 0.2 wt. %, based upon the total weight of the alcoholic pre-mix.

17. The method of claim 2, wherein the waxy component is present in an amount of at least 0.1 wt. %, based upon the total weight of the combined alcoholic pre-mix and aqueous pre-mix.

18. The method of claim 2, wherein the aqueous pre-mix further comprises an emulsifier selected from the group consisting of polysorbate, poloxamer, polyethoxylated siloxane polymer, or a mixture thereof.

19. The method of claim 2, wherein the alcoholic pre-mix further comprises an emulsifier selected from the group consisting of polysorbate, poloxamer, polyethoxylated siloxane polymer, or a mixture thereof.

20. The method of claim 2, wherein the emulsifier is a poloxamer.

21. The method of claim 2, wherein the aqueous pre-mix may further comprise up to about 49 wt. % C_1-6 alcohol.

22. The method of claim 2, wherein the foam expands upon the reaction of the acid and the carbonate to a final volume that is 1.5 to 5 times the combined liquid volume of the aqueous pre-mix and the alcoholic pre-mix.

23. The method of claim 2, wherein the foam is stable for at least 1 minute at room temperature and pressure.

24. (canceled)

25. An antimicrobial alcoholic foam composition that is obtainable from mixing:

(a) a first pre-mix composition that comprises at least 50 wt. % of a lower alcohol, based upon the total weight of the first pre-mix composition, an acidic component, and a waxy component, and

(b) a second pre-mix composition that comprises water and a carbonate.

27. The composition of claim 25, where the acidic component is selected from the group consisting of hydrochloric acid, nitric acid, phosphoric acid, phosphonic acid, boric acid, sulfuric acid, adipic acid, benzene 1,3,5 tricarboxylic acid, chlorosuccinic acid, choline chloride, cis-aconitic acid, citramalic acid, citric acid, cyclobutane 1,1,3,3 tetracarboxylic acid, cyclohexane 1,2,4,5 tetracarboxylic acid, cyclopentane 1,2,3,4 tetracarboxylic acid, diglycolic acid, fumaric acid, glutamic acid, glutaric acid, glyoxylic acid, isocitric acid, ketomalonic acid, lactic acid, maleic acid, malic acid, malonic acid, nitrilotriacetic acid, oxalacetic acid, oxalic acid, phytic acid, p-toluenesulfonic acid, salicylic acid, succinic acid, tartaric acid, tartronic acid, tetrahydrofuran 2,3,4,5 tetracarboxylic acid, tricarballylic acid, versene acids, 3-hydroxyglutaric acid, 2-hydroxypropane 1,3 dicarboxylic acid, glyceric acid, furan 2,5 dicarboxylic acid, 3,4-dihydroxyfuran-2,5 dicarboxylic acid, 3,4-dihydroxytetrahydrofuran-2,5-dicarboxylic acid, 2-oxo-glutaric acid, dl-glyceric acid, and 2,5 furandicarboxylic acid, tartaric acid, malic acid, gluconic acid, fumaric acid, ascorbic acid, citric acid, isocitric acid, lactic acid, tartronic acid, oxalic acid, salicylic acid, malonic acid, potassium bitartrate, calcium phosphate, sodium aluminum phosphate, sodium aluminum sulfate, monosodium phosphate, disodium pyrophosphate, calcium lactate, calcium sulfate, calcium phosphate, sodium aluminum phosphate, sodium aluminum sulfate, monosodium phosphate and disodium pyrophosphate, and mixtures thereof.

28. The composition of claim 25, wherein the acidic component is selected from the group consisting of citric acid, lactic acid, malic acid, tartaric acid, salicylic acid, oxalic acid, and mixtures thereof.

29. The composition of claim 25, wherein the acidic component is citric acid.

30. The composition of claim 25, wherein the amount of acidic component is at least 0.02 equivalent weights of acid per 100 g of combined aqueous pre-mix and alcoholic pre-mix.

31. The composition of claim 25, wherein the amount of acidic component is from 0.5 to about 2 times the number of equivalent weights of carbonate present in the aqueous pre-mix.

32. The composition of claim 25, wherein the amount of acidic component is the stoichiometric amount of acid required to produce at least 0.02 moles of carbon dioxide per 100 g of combined aqueous pre-mix and alcoholic pre-mix.

33. The composition of claim 25, wherein the carbonate is selected from the group consisting of sodium carbonate, potassium carbonate, lithium carbonate, sodium bicarbonate, potassium bicarbonate, calcium bicarbonate, ammonium bicarbonate, and mixtures thereof.

34. The composition of claim 25, wherein the carbonate is potassium bicarbonate.

35. The composition of claim 25, wherein the amount of carbonate is an effective amount.

36. The composition of claim 25, wherein the amount of carbonate is the stoichiometric amount of carbonate required to yield at least 0.02 moles of carbon dioxide per 100 g of combined aqueous pre-mix and alcoholic pre-mix.

37. The composition of claim 25, wherein the aqueous pre-mix is a saturated solution with respect to the carbonate.

38. The composition of claim 25, wherein the waxy component is selected from the group consisting of carnauba wax, ouricury wax, Japan wax, cork fiber wax, sugarcane wax, paraffin waxes, lignite waxes, microcrystalline waxes, lanolin wax, ozokerite, polyethylene wax, silicone waxes, plant waxes, C_8-24 fatty alcohols, C_8-24 fatty acids, glycerides that are solid at room temperature, blends of a C_8-24 fatty alcohol with an ethoxylated C_8-24 fatty alcohol, blends of a C_8-24 fatty alcohol and a non-ionic surfactant, and mixtures thereof, with the proviso that the wax is at least sparingly soluble in a lower alcohol at standard temperature and pressure.

39. The composition of claim 25, wherein the waxy component is an emulsifying wax.

40. The composition of claim 25, wherein the waxy component is present in an amount of at least 0.2 wt. %, based upon the total weight of the alcoholic pre-mix.

41. The composition of claim 25, wherein the waxy component is present in an amount of at least 0.1 wt. %, based upon the total weight of the combined alcoholic pre-mix and aqueous pre-mix.

42. The composition of claim 25, wherein the aqueous pre-mix further comprises an emulsifier selected from the group consisting of polysorbate, poloxamer, polyethoxylated siloxane polymer, or a mixture thereof.

43. The composition of claim 25, wherein the alcoholic pre-mix further comprises an emulsifier selected from the group consisting of polysorbate, poloxamer, polyethoxylated siloxane polymer, or a mixture thereof.

44. The composition of claim 25, wherein the emulsifier is a poloxamer.

45. The composition of claim 25, wherein the aqueous pre-mix may further comprise up to about 49 wt. % C_1-6 alcohol.

46. The composition of claim 25, wherein the foam expands upon the reaction of the acid and the carbonate to a final volume that is 1.5 to 5 times the combined liquid volume of the aqueous pre-mix and the alcoholic pre-mix.

47. The composition of claim 25, wherein the foam is stable for at least 1 minute at room temperature and pressure.

26. (canceled)