Systems and Methods For Improved Brain Monitoring During General Anesthesia And Sedation

• US 20150080754A1
• Filed: 09/12/2014
• Published: 03/19/2015
• Est. Priority Date: 09/13/2013
• Status: Active Grant

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Purdon, Patrick L., Brown, Emery N., Johnson-Akeju, Oluwaseun
• Granted Patent: US 10,602,978 B2
• Time in Patent Office: Days
• US Class Current: 600/544
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/374 Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves
• CPC Class Codes: A61B 5/4806 Sleep evaluation A61B5/4821 takes precedence; devices for inducing sleep A61M21/02
• CPC Class Codes: A61B 5/4821 Determining level or depth of anaesthesia A61B5/1106 takes precedence
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: A61B 5/7475 User input or interface means, e.g. keyboard, pointing device, joystick
• CPC Class Codes: G16H 15/00 ICT specially adapted for medical reports, e.g. generation or transmission thereof

Abstract

Systems and method for age-compensated monitoring of a patient experiencing administration of at least one drug having anesthetic properties are provided. In one embodiment, a system includes a plurality of sensors configured to acquire physiological data from the patient and at least one processor configured to receive the physiological data from the plurality of sensors, and determine, from the physiological data, signal markers indicative of an apparent or likely patient age. The at least one processor is also configured to at least one of scale and regulate the physiological data using at least the apparent patient age to create age-compensated data, and generate a report including the age-compensated data.

Claims

1. A system for age-compensated monitoring of a patient experiencing an administration of at least one drug having anesthetic properties, the system comprising:

a plurality of sensors configured to acquire physiological data from the patient while receiving the at least one drug having anesthetic properties;

at least one processor configured to;

acquire physiological data from the plurality of sensors;

determine, from the physiological data, signal markers at least consistent with a patient age; and

generate a report including at least the physiological data adjusted for the patient age based on at least one of the signal markers.

2. The system of claim 1 wherein the processor is further configured to identify signatures related to at least one of an amplitude and a power spectrum to determine the signal markers from the physiological data.

3. The system of claim 1 wherein the processor is further configured to adjust at least one of an amplifier gain and a scale for the report including at least the physiological data in based on at least one of the signal markers and the indication.

4. The system of claim 1 wherein the processor is further configured to assemble the physiological data into time-series data using a multitaper approach to account for a dynamic range of signals spanning several orders of magnitude.

5. The system of claim 1 further comprising a user interface configured to receive an indication of at least one characteristic of the patient and wherein the processor is further configured to adjust for the patient age based on the at least one a characteristic of the patient.

6. A method for age-compensated monitoring of a patient experiencing an administration of at least one drug having anesthetic properties, the method comprising:

acquiring scout data from the plurality of sensors;

determining, from the scout data, a patient age;

acquiring physiological data from the plurality of sensors; and

generating a report including the physiological data at least one of scaled and reported against a scale based on the patient age.

7. The method of claim 6 wherein determining the patient age includes determining signal markers from the scout data related to at least one of an amplitude and a power spectrum and comparing the signal markers against an age indicator.

8. The method of claim 6 further comprising regulating acquisition of the physiological data based on the patient age.

9. The method of claim 8 wherein regulating includes adjusting at least one amplifier gain based on the patient age.

10. The method of claim 8 wherein regulating includes performing a multitaper analysis to account for a dynamic range of signals spanning several orders of magnitude.

11. A system for age-compensated monitoring of a patient experiencing an administration of at least one drug having anesthetic properties, the system comprising:

a plurality of sensors configured to acquire physiological data from the patient;

at least one processor configured to;

receive the physiological data from the plurality of sensors;

determine, from the physiological data, signal markers indicative of an apparent patient age;

at least one of scale or regulate the physiological data using at least the apparent patient age to create age-compensated data; and

generate a report including the age-compensated data.

12. The system of claim 11 wherein the processor is further configured to identify signatures related to at least one of an amplitude and a power spectrum to determine the signal makers.

13. The system of claim 11 wherein the processor is further configured to adjust at least one amplifier gain in accordance with the signal markers to scale the physiological data.

14. The system of claim 11 further comprising a user interface configured to receive an input patient age of the patient and wherein the processor is further configured to at least one of scale and regulate the physiological data based on the apparent patient age and the input patient age.

15. A method for age-compensated monitoring of a patient experiencing an administration of at least one drug having anesthetic properties, the method comprising:

acquiring scout data from the plurality of sensors;

determining, from the scout data, a scale at least consistent with a patient age;

regulating acquisition of the physiological data based on the scale; and

generating a report including the physiological data associated with the scale.

16. The method of claim 15 wherein determining the scale includes identifying age-correlated signal markers from the scout data and selecting the scale from a plurality of scales based on the age-correlated signal markers.

17. The method of claim 15 wherein regulating acquisition of the physiological data comprises adjusting at least one amplifier gain based on the scale.

18. A system for age-compensated monitoring of a patient experiencing an administration of at least one drug having anesthetic properties, the system comprising:

a plurality of sensors configured to acquire physiological data from the patient;

a user interface configured to receive an indication of at least one of a characteristic of the patient;

a processor configured to;

determine, from at least the indication of at least one of a characteristic of the patient, a likely patient age;

select a scale based on the likely patient age; and

a display configured to display the physiological data against the scale.

19. The system of claim 18 wherein the processor is further configured to determine, from the physiological data, an apparent patient age and select the scale based on the apparent patient age and the likely age.

20. The system of claim 18 wherein the processor is further configured to perform a multitaper process to account for a dynamic range of signals spanning several orders of magnitude to format the physiological data to be displayed against the scale.