Fast Diagnosis and Personalized Treatment for Acne
3 Assignments
0 Petitions
Accused Products
Abstract
Methods of diagnosing and treating patients afflicted with acne, including diagnosing one as having acne if the individual possesses RT4, RT5, RT7, RT8, RT9, or RT10. Methods for treating acne include administering an effective amount of a drug specifically targeting RT4, RT5, RT7, RT8, RT9, or RT10, such as small molecules, antisense molecules, siRNAs, biologics, antibodies, phages, vaccines, or combination thereof.
66 Citations
39 Claims
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2. (canceled)
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3. A method for diagnosing different types of acne comprising:
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obtaining a skin sample from a subject; isolating bacterial DNA from said sample; amplifying bacterial DNA in said sample; and typing the subject'"'"'s DNA based on one or more of the five major microbiome types of P. acnes strains, wherein said subject is diagnosed as having acne if said subject is typed to microbiome IV or V. - View Dependent Claims (1, 4, 5, 7, 8, 10, 11)
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6. (canceled)
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9. (canceled)
- 12. A vaccine for the prevention and/or treatment of acne caused by P. acnes comprising a heat inactivated P. acnes strain, an attenuated protein of said strain, or combination thereof, wherein said strain is an RT4 strain, an RT5 strain, an RT7 strain, an RT8 strain, an RT9 strain, or an RT10 strain.
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16. (canceled)
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18-29. -29. (canceled)
- 30. A composition comprising at least one strain of P. acnes that is associated with healthy or normal skin.
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33-35. -35. (canceled)
- 36. A method for the personalized treatment of acne comprising determining the strain(s) of acne affecting a subject and administering to said subject an effective amount of at least one phage specifically directed to said strain(s).
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39-46. -46. (canceled)
Specification