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DIGITAL COUNTING OF INDIVIDUAL MOLECULES BY STOCHASTIC ATTACHMENT OF DIVERSE LABELS

  • US 20150099673A1
  • Filed: 11/12/2014
  • Published: 04/09/2015
  • Est. Priority Date: 12/15/2009
  • Status: Active Grant
First Claim
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1. A system for counting n, wherein n is a number of nucleic acid target molecules that are present in a sample, the system comprising:

  • a a diverse set of labels, wherein the set comprises different labels, wherein >

    n; and

    b a plurality of reaction vessels for attaching a label from the diverse set of labels to each occurrence of the nucleic acid target molecules from a single cell to generate a set of labeled nucleic acid target molecules, wherein the individual labeled nucleic acid target molecules comprise all or a portion of the complementary sequence of a nucleic acid target molecule and a label from the diverse set of labels.

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