CONTROL OF MAGNETIC ROTORS TO TREAT THERAPEUTIC TARGETS
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Abstract
A system for the physical manipulation of free magnetic rotors in a circulatory system using a remotely placed magnetic field-generating stator is provided. In one embodiment, the invention relates to the control of magnetic particles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Examples of vascular occlusions targeted by the system include, but are not limited to, atherosclerotic plaques, including fibrous caps, fatty buildup, coronary occlusions, arterial stenosis, restenosis, vein thrombi, arterial thrombi, cerebral thrombi, embolisms, hemorrhages, other blood clots, and very small vessels.
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Citations
21 Claims
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1. (canceled)
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2. A system for increasing diffusion of a pharmaceutical composition in a body lumen of a subject comprising:
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a plurality of individual magnetic rotors; a magnet having a magnetic field and a gradient; and a controller configured to position and rotate the magnetic field and to control the gradient in a manner to (i) cause the individual magnetic rotors to form ensembles in which each individual magnetic rotor generally rotates simultaneously and travels in the same direction as a group and (ii) cause the ensembles to travel toward a therapeutic target in a body lumen in an end over end motion to collectively create hydrodynamic forces that generate turbulence and increase diffusion of a pharmaceutical composition capable of inducing a desired therapeutic effect in the body lumen. - View Dependent Claims (3, 4, 5, 6, 7, 8)
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9. A system for increasing diffusion of a pharmaceutical composition in a body lumen of a subject comprising:
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a magnet having a magnetic field and a gradient; and a controller configured to position and rotate the magnetic field and to control the gradient in a manner to (i) cause individual magnetic nanoparticles introduced within the subject to agglomerate into magnetic rods and (ii) cause the magnetic rods to travel toward a therapeutic target in a body lumen in an end over end motion to collectively create hydrodynamic forces that generate turbulence and increase diffusion of a pharmaceutical composition capable of inducing a desired therapeutic effect in the body lumen. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17)
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18. A system for increasing diffusion of a pharmaceutical composition in a body lumen of a subject comprising:
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a magnet having a magnetic field and a gradient; and a controller configured to position and rotate the magnetic field and to control the gradient in a manner to cause magnetic rotors introduced within the subject to travel toward a therapeutic target in a body lumen in an end over end motion to collectively increase diffusion of a therapeutic agent to the location of the therapeutic target even with no fluid flow, thereby increasing interaction between the therapeutic agent and the therapeutic target in the body lumen. - View Dependent Claims (19, 20, 21)
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Specification