Injection Device

• US 20150100028A1
• Filed: 12/15/2014
• Published: 04/09/2015
• Est. Priority Date: 06/16/2000
• Status: Active Grant

• Current Assignee: Novo Nordisk A/S
• Original Assignee: Novo Nordisk A/S
• Inventors: Moeller, Claus Schmidt
• Granted Patent: US 10,245,383 B2
• Time in Patent Office: Days
• US Class Current: 604/211
• CPC Class Codes: A61M 2005/3152 including gearings to multiply or attenuate the piston displacing force
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/28 Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
• CPC Class Codes: A61M 5/315 Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
• CPC Class Codes: A61M 5/31541 Means preventing setting of a dose beyond the amount remaining in the cartridge
• CPC Class Codes: A61M 5/3155 by rotational movement of dose setting member, e.g. during setting or filling of a syringe
• CPC Class Codes: A61M 5/31551 including axial movement of dose setting member
• CPC Class Codes: A61M 5/31558 using scaling up or down transmissions, e.g. gearbox
• CPC Class Codes: A61M 5/31575 using scaling up or down transmissions, e.g. gearbox
• CPC Class Codes: A61M 5/3158 performed by axially moving actuator operated by user, e.g. an injection button

Abstract

A medication dispensing device with a housing and a member wherein the member is moveable in a distal direction is useful in delivering medication to a patient. A fluid container can be used with the device and often has a moveable piston at one end and an outlet at the other. The member receives a force from a user and drives the piston in the distal direction to expel medication. An intermediate system is disposed between the member and the piston including a gear set that has a pinion in meshed engagement with a rack. The system allows the member to move a greater distance than the piston moves thereby increasing the force on the piston.

Claims

1. An injection syringe apparatus by which a dose can be set by rotating a dose setting member and by which an injection button elevates from an end of the syringe apparatus a distance proportional to the set dose, the injection syringe apparatus comprising:

a. a non-rotatable, longitudinally displaceable, guided threaded piston rod having a distal end for pressing medicine out of a cartridge;

b. a tubular element that is rotatable and axially displaceable, wherein the injection button is fixed to the tubular element at a proximal end of the tubular element so that the injection button rotates and translates with the tubular element;

c. a housing element;

d. a nut element threadedly engaging the thread on the piston rod thereby forming a first threaded arrangement, wherein the nut element screws up the piston rod away from a defined position in the housing and can be pressed back to the defined position carrying the piston rod with it when a set dose is injected, wherein the axial distance the nut element is moved is less than the axial distance the injection button is moved;

wherein the nut element comprises a connecting element comprised of connection bars or a tubular connection element for rotating the nut element when the dose setting member is rotated;

e. a dose setting drum that rotates during the setting of a dose, the dose setting drum being threadedly engaged with the housing element via a second threaded arrangement so that when the threaded dose setting drum is rotated it is axially displaced relative to the housing, wherein the second threaded arrangement is different than the first threaded arrangement so that the injection button has a larger stroke than the piston rod;

f. a helical scale disposed on an exterior surface of the dose setting drum; and

g. a coupling that couples and decouples rotational motion of the dose setting drum with the tubular element and the injection button, the coupling comprised of a pair of releaseably engageable elements, wherein when a dose is set by rotating the dose setting drum, the tubular element and dose setting drum rotate together but when a user injects a dose by pressing on the injection button, the dose setting drum is rotationally decoupled from the tubular element so that the dose setting drum rotates back to a zero position while the tubular element, the nut element, the piston rod, and the injection button move axial without rotating.

2. An injection syringe apparatus according to claim 1, further comprising a wall.

3. An injection syringe apparatus as in claim 1, wherein the thread on the dose setting drum is an internal thread that threadedly engages an external thread on a non-rotatable tubular member.

4. An injection syringe apparatus as in claim 1, further comprising a spring that maintains the coupling in a coupled state, and wherein when an axial force is applied to the injection button in a distal direction, the coupling decouples rotation of the dose setting drum from the tubular element.

5. The injection syringe apparatus of claim 1, further comprising a dose limiter that prevents the setting of a dose that exceeds the amount of medicament left.

6. The injection syringe apparatus of claim 5, wherein the dose limiter comprises a stop on the threaded piston rod.

7. The injection syringe apparatus of claim 6, further comprising a click coupling comprised of a cylindrical ring element that moves axially without rotating and follows axial movement of the dose setting drum and emits a click sound during dose setting.

8. The injection syringe apparatus of claim 1 in combination with a gear wheel gear transmission that is established between the injection button and the nut element.

18. An injection syringe apparatus of claim 1, further comprising an axially moveable cylindrically shaped ring element that contains a toothed surface that engages teeth on the tubular element when the injection button is pressed in a distal direction.

19. The injection syringe apparatus of claim 18, in combination with a transmission that is established between the injection button and the nut element.

20. The combination as in claim 19, wherein the transmission is a gear transmission.

21. The combination as in claim 20, wherein the gear transmission is a gear wheel transmission.

9. An injection syringe apparatus in which, an injection button elevates a distance proportional to a set dose, the syringe apparatus comprising:

a non-rotating, longitudinally displaceable, guided threaded piston rod;

a nut element having a connection element comprised of either connection bars or a tubular connection element for rotating the nut element, the nut element threaded to the piston rod via a first threaded arrangement so that when it rotates it moves longitudinally along the piston rod;

a tubular element that rotates with the nut element and connection element, the tubular element having the injection button disposed on a proximal end of the tubular element;

a dose setting drum threadedly engaged with a housing element via a second different threaded arrangement, the dose setting drum comprising a scale on its outer surface;

a coupling that couples and decouples rotational movement of the dose setting drum and the tubular element, wherein a spring biases the coupling so that the coupling is in a coupled state until the injection button is pressed;

wherein during dose setting;

the dose setting drum, tubular element, and nut element are coupled together so that they rotate together, and the nut element is screwed up along the piston rod in a proximal direction and away from a defined position in the housing while the dose setting drum is screwed up relative to the housing also in a proximal direction and carries with it the injection button in a proximal direction; and

wherein when the injection button is pressed;

the coupling decouples rotation of the dose setting drum from the tubular element so that the tubular element, the nut element, and the piston rod move longitudinally without rotating while the dose setting drum moves axially and rotates to a zero position, and wherein the stroke of the injection button is greater than the stroke of the piston rod; and

wherein the distance the nut element was screwed up along the piston rod during dose setting corresponds to the size of the dose.

10. The injection syringe apparatus of claim 9, further comprising a dose limiter that prevents the setting of a dose that exceeds the amount of medicament left in the pen.

11. The injection syringe apparatus of claim 9, further comprising a click coupling that makes a click sound when setting a dose.

12. The injection syringe apparatus of claim 10, further comprising a click coupling that makes a click sound, the click coupling comprising an axially displaceable non-rotating cylindrical ring that emits a click sound when setting a dose, wherein the click coupling moves axially and follows the axial movement of the dose setting drum.

13. The injection syringe apparatus of claim 12, wherein the dose limiter comprises a stop on the piston rod for engaging the nut element.

14. In combination, an injection syringe apparatus of any of claims 9-13 and a transmission that is established between the nut element and the injection button.

15. The combination of claim 14, wherein the transmission is a gear transmission.

16. The combination of claim 15, wherein the gear transmission is a gear wheel gear transmission.

17. The injection syringe apparatus of claim 9, further comprising a return spring coupled to the dose setting drum for returning the dose setting drum to the zero position during injection.

22. An injection syringe apparatus by which a dose can be set by rotating a dose setting member and by which an injection button elevates a distance proportional to the set dose, the syringe apparatus comprising:

a non-rotating, longitudinally displaceable, guided threaded piston rod;

a nut element having a connection element comprised of either connection bars or a tubular connection element for rotating the nut element, the nut element threaded to the piston rod via a first threaded arrangement so that when it rotates it moves longitudinally along the piston rod;

a dose setting drum threadedly engaged with a housing element via a second different threaded arrangement, the dose setting drum comprising a scale on its outer surface;

a coupling that couples and decouples rotational movement of the dose setting drum and the injection button;

a spring that biases the coupling so that the coupling is in a coupled state until the injection button is pressed;

wherein when the dose setting member is rotated during dose setting;

the dose setting drum, the injection button which is fixed to the dose setting member at its proximal end, and the nut element are coupled together so that they rotate together, and the nut element is screwed up along the piston rod in a proximal direction and away from a defined position in the housing while the dose setting drum is screwed up relative to the housing also in a proximal direction with the injection button; and

wherein when the injection button is pressed;

the coupling decouples rotation of the dose setting drum from the injection button so that the injection button, the nut element, and the piston rod move longitudinally without rotating while the dose setting drum moves axially and rotates to a zero position, and wherein the stroke of the injection button is greater than the stroke of the piston rod; and

wherein the distance the nut element was screwed up along the piston rod during dose setting corresponds to the size of a set dose.

23. The injection syringe apparatus of claim 22, further comprising a dose limiter that is comprised of a stop on the threaded piston rod, the dose limiter for preventing the setting of a dose that exceeds the amount of medication remaining in the pen.

24. The injection syringe apparatus of claim 23, further comprising an axially moveable cylindrically shaped element that contains a toothed surface that engages teeth that are fixed to the injection button, wherein when the injection button is pressed in a distal direction, the teeth engage the cylindrically shaped element.

25. The injection syringe apparatus of claim 23, further comprising a click coupling that makes a click sound, the click coupling comprising an axially displaceable non-rotating cylindrical element that emits a click sound when setting a dose, wherein the click coupling moves axially and follows the axial movement of the dose setting drum.

26. In combination, the injection syringe apparatus of claim 25 and a transmission that is established between the injection button and the nut element.

27. The combination as in claim 26, wherein the transmission is a gear transmission.

28. The combination as in claim 26, wherein the transmission is a gear wheel transmission.

29. An injection syringe apparatus by which a dose can be set by rotating a dose setting member which elevates in a proximal direction a distance proportional to the set dose, the syringe apparatus comprising:

a non-rotating, longitudinally displaceable, guided threaded piston rod;

a nut element having connection element comprised of either connection bars or a tubular connection element for rotating the nut element, the nut element threaded to the piston rod via a first threaded arrangement so that when it rotates it moves longitudinally along the piston rod;

an injection button, which is formed at a proximal end of the dose setting member;

a dose setting drum threadedly engaged with a housing element via a second different threaded arrangement, the dose setting drum comprising a scale on its outer surface;

a coupling that couples and decouples rotational movement of the dose setting drum and the nut element;

wherein when the dose setting member is rotated during dose setting;

the dose setting drum and nut element are coupled together so that they rotate together, and the nut element is screwed up along the piston rod in a proximal direction and away from a defined position in the housing while the dose setting drum is screwed up relative to the housing also in a proximal direction and carries with it the injection button in a proximal direction; and

wherein during injection;

the coupling decouples rotation of the dose setting drum from the nut element, and the nut and piston rod move longitudinally without rotating while the dose setting drum moves axially and rotates to a zero position, and wherein the stroke of the injection button is greater than the stroke of the piston rod; and

wherein the distance the nut element was screwed up along the piston rod during dose setting corresponds to the size of a set dose.

30. The injection syringe apparatus of claim 29, further comprising a spring that biases the coupling in a coupled state where rotational motion of the dose setting drum is transmittable to the nut element.

31. The injection syringe apparatus of claim 29 or 30, further comprising a non-rotating axially displaceable generally cylindrically shaped element that toothedly engages with teeth that are fixed to the button and wherein the generally cylindrically shaped element follows axial movement of the dose setting drum.

32. The injection syringe apparatus of claim 31, wherein the generally cylindrically shaped element further comprises a click coupling that makes a click sound when the dose setting drum is rotated during dose setting.

33. The injection syringe apparatus of claim 32, further comprising a dose limiter that prevents the setting of a dose larger than the amount of medicament remaining.

34. In combination, the injection syringe apparatus of claim 33 with a transmission that engages with the nut element to drive the nut element and carry with it the piston rod during an injection.

35. The injection syringe apparatus of claim 31, wherein the generally cylindrically shaped element further comprises a click coupling that makes a click sound when the dose setting drum is rotated during dose setting and wherein it follows axial movement of the dose setting drum in that it moves in the same direction that the dose setting drum is moving.

36. An injection syringe apparatus by which a dose can be set by rotating a dose setting member, the syringe apparatus comprising:

a threaded piston rod;

a nut element that threadedly engages with the piston rod and that screws up along the piston rod in a proximal direction during dose setting;

a dose setting drum threadedly engaged with a housing element, the dose setting drum comprising a scale on its outer surface, wherein the dose setting member is located proximal to the dose setting drum;

a tubular element connected to the dose setting member and having a plurality of teeth disposed thereon;

a coupling that couples and decouples rotational movement of the dose setting drum and the nut element;

a ring element that moves axially but does not rotate and follows the dose setting drum when the drum moves axially, the ring element having a set of teeth that are complementary and engage the teeth on the tubular element;

wherein when the dose setting member is rotated during dose setting;

the dose setting drum and tubular element and nut element are coupled together so that they rotate together, and the nut element is screwed up along the piston rod in a proximal direction and away from a defined position in the housing while the dose setting drum is screwed up relative to the housing also in a proximal direction and carries with it the injection button in a proximal direction wherein during dose setting the teeth on the tubular element click over the teeth on the ring element; and

wherein during injection;

the coupling decouples rotation of the dose setting drum from the tubular element and the nut element, and the tubular element move longitudinally without rotating and the piston rod moves in a distal direction to expel drug while the dose setting drum moves axially and rotates to a zero position, and wherein the stroke of the injection button is greater than the stroke of the piston rod and wherein teeth on the tubular element move into and engage the teeth on the ring element.