MUCOSA-ELEVATING AGENT

• US 20150105336A1
• Filed: 03/08/2013
• Published: 04/16/2015
• Est. Priority Date: 03/09/2012
• Status: Abandoned Application

• Current Assignee: 3-D Matrix Limited
• Original Assignee: 3-D Matrix Limited
• Inventors: Takamura, Kentaro, Kobayashi, Satoru, Matsuda, Noriaki
• Application Number:
  US14/383,801
• Publication Number:
  US 20150105336A1
• Time in Patent Office: Days
• US Class Current: 514/21.4
• CPC Class Codes: A61K 38/10 Peptides having 12 to 20 amino acids A61K38/043 - A61K38/046 take precedence
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 47/42 Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein oligopeptides having up to five amino acids A61K47/183; polyamino acids A61K47/34
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/0053 Mouth and digestive tract, i.e. intraoral and peroral administration rectal administration A61K9/0031
• CPC Class Codes: A61K 9/06 Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels composition of ointments, creams or gels A61K47/00
• CPC Class Codes: A61L 2430/34 for soft tissue reconstruction
• CPC Class Codes: A61L 27/22 Polypeptides or derivatives thereof , e.g. degradation products
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 41/00 Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/04 Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
• CPC Class Codes: C07K 7/08 having 12 to 20 amino acids gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68

Abstract

Provided is a mucosa-elevating agent containing 0.1% to 1.0% of a peptide, wherein the peptide is an amphipathic protein having 8 to 200 amino acid residues in which hydrophilic amino acids and hydrophobic amino acids are alternately bonded, and is a self-assembling peptide that exhibits a β structure in an aqueous solution at physiological pH and/or in the presence of cations.

Claims

1. A mucosa-elevating agent containing 0.1% to 1.0% of a peptide, wherein the peptide is an amphipathic protein having 8 to 200 amino acid residues in which hydrophilic amino acids and hydrophobic amino acids are alternately bonded, and is a self-assembling peptide that exhibits a β

structure in an aqueous solution at physiological pH and/or in the presence of cations.

2. The mucosa-elevating agent according to claim 1, wherein the peptide has a repetitive sequence of a sequence consisting of arginine, alanine, aspartic acid and alanine, a sequence consisting of isoleucine, glutamic acid, isoleucine and lysine, or a sequence consisting of lysine, leucine, aspartic acid and leucine.

3. The mucosa-elevating agent according to claim 1 or 2, wherein the peptide is consisted of the amino acid sequence described in SEQ ID NO:

1, SEQ ID NO;

2 or SEQ ID NO;

3.

4. The mucosa-elevating agent according to claim 1, further containing a pharmaceutical agent.

5. The mucosa-elevating agent according to claim 4, wherein the pharmaceutical agent is a pharmaceutically acceptable pigment.

6. The mucosa-elevating agent according to claim 4, wherein the pharmaceutical agent is

selected from the group consisting of glucose, sucrose, refined sucrose, lactose, maltose, trehalose, dextran, iodine, lysozyme chloride, dimethyl isopropylazulene, tretinoin tocoferil, iodopovidone, alprostadil alfadex, anisyl alcohol, isoamyl salicylate, α

,α

-dimethylphenylethyl alcohol, bacdanol, helional, silver sulfadiazine, bucladesine sodium, alprostadil alfadex, gentamycin sulfate, tetracycline hydrochloride, fusidate sodium, mupirocin calcium hydrate and isoamyl benzoate.

7. The mucosa-elevating agent according to claim 1, which is injected between a mucous membrane and a muscle layer.

8. The mucosa-elevating agent according to claim 1, wherein the mucous membrane is gastrointestinal mucosa.

9. The mucosa-elevating agent according to claim 1, which is used in mucosal resection.

10. The mucosa-elevating agent according to claim 1, which is used in submucosal layer dissection.

11. The mucosa-elevating agent according to claim 1, which can be additionally injected.

12. The mucosa-elevating agent according to claim 1, which is in a form of being filled in a syringe.

13. The mucosa-elevating agent according to claim 1, which has a wound-healing effect.

14. The mucosa-elevating agent according to claim 1, which has a scar-preventing effect or constriction-preventing effect.

15. The mucosa-elevating agent according to claim 1, which has a hemostatic effect.

16. The mucosa-elevating agent according to claim 1, which is in a liquid form that gels in the body.