Methods of Using Near Field Optical Forces
First Claim
Patent Images
1. A method of measuring at least one property of a substance comprising:
- positioning a substance in the vicinity of near-field light of an optical trap;
directing light from a light source to the substance;
detecting the effect of the light on the substance; and
measuring at least one property of the substance based on the detected effect.
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Abstract
Methods of studying, interrogating, analyzing, and detecting particles, substances, and the like with near field light are described. Methods of identifying binding partners, modulators, inhibitors, and the like of particles, substances, and the like with near field light are described. In certain embodiments, the methods comprise immobilizing or trapping the particle, substance, and the like.
13 Citations
37 Claims
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1. A method of measuring at least one property of a substance comprising:
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positioning a substance in the vicinity of near-field light of an optical trap; directing light from a light source to the substance; detecting the effect of the light on the substance; and measuring at least one property of the substance based on the detected effect. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method of measuring the binding activity of a substance comprising;
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immobilizing the substance at a location using an optical trap, thereby forming a trapped substance; contacting the trapped substance with one or more test substances; and detecting the binding of the strapped substance with one or more test substances. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22)
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23. A method of identifying a modulator of a substance comprising:
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immobilizing the substance at a location using an optical trap, thereby forming a trapped substance; contacting the trapped substance with one or more test substances; and measuring a property of the trapped substance, wherein a change in the property of the trapped substance when contacted with the test substance indicates that the test substance is a modulator of the substance. - View Dependent Claims (24, 25, 26, 27, 28)
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29. A system for measuring a property of a substance comprising:
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at least one optical trap; and at least one detector for measuring the property of the substance. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37)
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Specification