HOLLOW MICRONEEDLE AND SUBRETINAL SYRINGE FOR SUBRETINAL INJECTION OR EXTRACTION
First Claim
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1. A method for fabricating a hollow microneedle for subretinal injection or extraction, the method comprising:
- (a) coating a solution of a viscous material onto a surface of a substrate;
(b) placing a frame into contact with the solution of the viscous material;
(c) preparing a solid microneedle by lifting the substrate, the frame, or both the substrate and the frame, so as to space apart the contacted frame and substrate from each other;
(d) imparting a curved shape to the solid microneedle during step (c) or after completing step (c);
(e) depositing a metal onto the solid microneedle with the curved shape;
(f) plating the metal-deposited microneedle with a metal;
(g) bevel-cutting the tip of the metal-plated solid microneedle; and
(h) removing the solid microneedle to obtain a hollow microneedle with a curved shape.
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Abstract
The present invention relates to a method for manufacturing a hollow microneedle for subretinal injection or extraction. The microneedle for subretinal injection or extraction is made of metal, thereby providing the strength and force for penetrating the sclera and retina. Due to the length and the angle of curvature, the microneedle for subretinal injection or extraction of the present invention can reach a suitable subretinal site, such as the midperiphery at which optic nerves are accumulated, and thus the present invention is effective for delivering a drug and can enhance the effectiveness of the drug.
8 Citations
19 Claims
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1. A method for fabricating a hollow microneedle for subretinal injection or extraction, the method comprising:
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(a) coating a solution of a viscous material onto a surface of a substrate; (b) placing a frame into contact with the solution of the viscous material; (c) preparing a solid microneedle by lifting the substrate, the frame, or both the substrate and the frame, so as to space apart the contacted frame and substrate from each other; (d) imparting a curved shape to the solid microneedle during step (c) or after completing step (c); (e) depositing a metal onto the solid microneedle with the curved shape; (f) plating the metal-deposited microneedle with a metal; (g) bevel-cutting the tip of the metal-plated solid microneedle; and (h) removing the solid microneedle to obtain a hollow microneedle with a curved shape. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 16)
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13. A subretinal syringe or extractor comprising a hollow microneedle, wherein the hollow microneedle has an effective length of 1 to 10 mm, an inner diameter at the upper end of 20 to 150 μ
- m, a bevel angle of 5 to 50 degrees, and a curved angle of 10 to 70 degrees.
- View Dependent Claims (14, 15, 17, 18, 19)
Specification