METHODS OF TREATING BACTERIAL INFECTIONS
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Abstract
The present invention relates to compounds, compositions and methods for treating bacterial infections. Embodiments of the present invention include antibiotics and β-lactamase inhibitors to treat resistant infections.
23 Citations
79 Claims
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1-44. -44. (canceled)
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45. A method of increasing sensitivity of a bacterial infection to treatment with an antimicrobial β
- -lactam compound resistant to degradation by a metallo β
-lactamase, wherein the antimicrobial compound resistant to degradation by a metallo β
-lactamase has a minimum inhibitory concentration for E. coli expressing the metallo β
-lactamase less than about 0.05 μ
g/ml, said method comprising;identifying a bacterial infection as including bacteria that comprises a serine β
-lactamase and the metallo β
-lactamase; andcontacting said bacteria with an effective amount of a β
-lactamase inhibitor, wherein the β
-lactamase inhibitor is selected from the group consisting of;
- -lactam compound resistant to degradation by a metallo β
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46. (canceled)
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47. A method of treating a bacterial infection that includes bacteria comprising a serine β
- -lactamase and a metallo β
-lactamase, said method comprising;contacting said bacteria with a β
-lactamase inhibiting effective amount of a β
-lactamase inhibitor and an antibacterially effective amount of an antimicrobial β
-lactam compound resistant to degradation by a metallo β
-lactamase, wherein the antimicrobial compound resistant to degradation by the metallo β
-lactamase has a minimum inhibitory concentration for E. coli expressing the metallo β
-lactamase less than about 0.05 μ
g/ml, wherein the β
-lactamase inhibitor is selected from the group consisting of; - View Dependent Claims (48, 49, 50, 56, 63, 65, 66, 67, 68, 70, 71, 72, 73, 74, 75, 76, 79)
- -lactamase and a metallo β
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51. (canceled)
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53. (canceled)
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54. A method of increasing sensitivity of a bacterial infection to treatment with an antimicrobial β
- -lactam compound resistant to degradation by a metallo β
-lactamase, wherein the sensitivity to the antimicrobial compound resistant to degradation by the metallo β
-lactamase of the bacteria contacted with the β
-lactamase inhibitor increases at least about 2-fold compared to bacteria not contacted with the β
-lactamase inhibitor, said method comprising;identifying a bacterial infection as including bacteria that comprises a serine β
-lactamase and the metallo β
-lactamase; andcontacting said bacteria with an effective amount of a β
-lactamase inhibitor, wherein the β
-lactamase inhibitor is selected from the group consisting of;
- -lactam compound resistant to degradation by a metallo β
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55. (canceled)
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78. (canceled)
Specification