Cyclosporine-Containing Non-Irritative Nanoemulsion Ophthalmic Composition
First Claim
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1. A nanoemulsion ophthalmic composition, comprising:
- 0.01 to 1 wt % of cyclosporine;
0.5 to 9.79 wt % of polyethoxylated castor oil or polyethoxylated hydrogenated castor oil; and
90 to 99.29 wt % of phosphate buffer,wherein the composition uses the polyethoxylated castor oil or polyethoxylated hydrogenated castor oil as a solubilizer of the cyclosporine, so that a separate oil or emulsifier is unnecessary, and the composition is prepared by simple mixing.
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Abstract
Provided is an ophthalmic composition containing cyclosporine as an active ingredient and including polyethoxylated castor oil or polyethoxylated hydrogenated castor oil, and a method of preparing the same. Particularly, the ophthalmic composition is prepared as a nanoemulsion having a particle diameter of 100 nm or less simply by mixing and stirring an oil phase and an aqueous phase without using a high speed stirring or shearing machine, so that it is very physiochemically stable and storable for a long time. In addition, the ophthalmic composition causes no irritation to eyes.
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10 Claims
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1. A nanoemulsion ophthalmic composition, comprising:
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0.01 to 1 wt % of cyclosporine; 0.5 to 9.79 wt % of polyethoxylated castor oil or polyethoxylated hydrogenated castor oil; and 90 to 99.29 wt % of phosphate buffer, wherein the composition uses the polyethoxylated castor oil or polyethoxylated hydrogenated castor oil as a solubilizer of the cyclosporine, so that a separate oil or emulsifier is unnecessary, and the composition is prepared by simple mixing. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification