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OLIGONUCLEOTIDE COMPOUND AND METHOD FOR TREATING NIDOVIRUS INFECTIONS

  • US 20150126722A1
  • Filed: 06/04/2014
  • Published: 05/07/2015
  • Est. Priority Date: 12/24/2003
  • Status: Abandoned Application
First Claim
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1. An oligonucleotide compound, which is composed of morpholino subunits and uncharged, phosphorus-containing intersubunit linkages joining a morpholino nitrogen of one subunit to a 5′

  • exocyclic carbon of an adjacent subunit, for use in inhibiting replication of a nidovirus in host cells, characterized by;

    (i) a nuclease-resistant backbone,(ii) capable of uptake by virus-infected host cells,(iii) containing between 8-25 nucleotide bases,(iv) having a sequence that is complementary to at least 12 contiguous bases contained in SEQ ID NO;

    1; and

    (v) capable of forming with SEQ ID NO;

    1, a heteroduplex structure characterized by a Tm of dissociation of at least 45°

    C.

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