COMPOSITE BONE GRAFT DEVICE

• US 20150127106A1
• Filed: 01/05/2015
• Published: 05/07/2015
• Est. Priority Date: 01/28/2011
• Status: Active Grant

• Current Assignee: Spinesmith Partners L P
• Original Assignee: Spinesmith Partners L P
• Inventors: Rossman, John B., Sand, Theodore, Burkinshaw, Brian, Partee, Colan
• Granted Patent: US 9,623,148 B2
• Time in Patent Office: Days
• US Class Current: 623/17.11
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/44 for the spine, e.g. vertebrae, spinal discs
• CPC Class Codes: A61F 2/4644 Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material bone material A61F2/28; disintegrating or milling devices B02C
• CPC Class Codes: A61F 2002/2817 Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
• CPC Class Codes: A61F 2002/2835 Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
• CPC Class Codes: A61F 2002/30909 Nets
• CPC Class Codes: A61F 2002/4495 having a fabric structure, e.g. made from wires or fibres
• CPC Class Codes: A61F 2310/00293 containing a phosphorus-containing compound, e.g. apatite
• CPC Class Codes: A61F 2310/00359 Bone or bony tissue
• CPC Class Codes: A61L 2400/06 Flowable or injectable implant compositions
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 2430/38 for reconstruction of the spine, vertebrae or intervertebral discs
• CPC Class Codes: A61L 27/3608 Bone, e.g. demineralised bone matrix [DBM], bone powder
• CPC Class Codes: A61L 27/3616 Blood, e.g. platelet-rich plasma
• CPC Class Codes: A61L 27/365 Bones
• CPC Class Codes: A61L 27/3834 Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body

Abstract

A composite bone graft which comprises an allograft bone component; a synthetic bone substitute, wherein the synthetic bone substitute is in contact with the allograft bone component. The composite is arranged within a resorbable mesh casing.

Claims

1. A composite bone graft comprising:

an allograft bone component;

a synthetic bone substitute, wherein the synthetic bone substitute is in contact with the allograft bone component; and

a resorbable mesh casing, wherein the composite bone graft is disposed within the resorbable mesh casing and the resorbable mesh casing holds the composite bone graft together and prevents dissipation of the composite bone graft.

2. The composite of claim 1 wherein the allograft bone component and synthetic bone substitute are at least partially infused with an additive, wherein the additive is one or more of platelet rich plasma, bone marrow aspirate, or stem cells.

3. The composite of claim 1, further comprising a bone graft syringe, wherein the composite bone graft is positioned within the bone graft syringe.

4. The composite of claim 1, wherein the synthetic bone substitute is a mixture of hydroxyapatite and gelatin;

and wherein the allograft bone is in the form of dense cortical bone strips, packed bone chips, or demineralized bone matrix.

5. The composite of claim 1, wherein the mesh casing is composed of a first vertical tube-shaped structure and a second vertical tube-shaped structure, wherein the first and second vertical tube-shaped structures are tranversely linked by a horizontal tube-shaped structure.

6. The composite of claim 5, wherein the horizontal tube-shaped structure is of a shorter length than the first and second vertical tube-shaped structures.

13. A method of treating an area of bone, comprising:

attaching the bone graft composite of claim 1 to an implantable surgical instrument; and

applying the bone graft composite to an area of bone.

14. The method of claim 13, wherein the area of bone is a posterolateral portion of spine.

15. The method of claim 13, wherein the area of bone comprises a bony pathology.

16. The method of claim 13 wherein the bone graft composite is applied to a gap in a bone or between two adjacent bones.

7. A method for using a composite bone graft comprising:

providing a bone graft syringe having a composite bone graft disposed within the bone graft syringe;

connecting the bone graft syringe to a delivery syringe, wherein the delivery syringe is further described as containing an injectable component selected from the group consisting of a cell concentrate, a platelet rich plasma, a bone marrow aspirate, or a clotting agent;

injecting the injectable component into the bone graft syringe; and

expelling the composite bone graft and the injectable component from the bone graft syringe.

8. The method for using the bone graft of claim 7, further comprising the step of filling a mesh casing with a composite bone graft.

9. A composite bone graft kit comprising:

a bone graft syringe;

a composite bone graft disposed within the bone graft syringe, wherein the composite bone graft is further defined as having an allograft bone component and a synthetic bone substitute component.

10. The composite bone graft kit of claim 9, further comprising a mesh casing.

11. The composite bone graft kit of claim 9, further comprising a delivery syringe that connects to the bone graft syringe.

12. The composite bone graft kit of claim 11, further comprising platelet rich plasma, bone marrow aspirate, stem cells, or combinations thereof.