Tamper Resistant Co-Extruded Dosage Form Containing an Active Agent and an Adverse Agent and Process of Making Same
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Accused Products
Abstract
The present invention relates to co-extruded pharmaceutical compositions and dosage forms including an active agent, such as an opioid agonist, and an adverse agent, such as an opioid antagonist. Such compositions and dosage forms arc useful for preventing or discouraging tampering, abuse, misuse or diversion of a dosage form containing an active pharmaceutical agent, such as an opioid. The present invention also relates to methods of treating a patient with such a dosage form, as well as kits containing such a dosage form with instructions for using the dosage form to treat a patient.
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Citations
31 Claims
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1-11. -11. (canceled)
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12. A co-extruded dosage form comprising:
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a core comprising an adverse agent; a sheath comprising a hydrophobic material which surrounds at least a portion of the core; and a shell comprising an active agent which surrounds at least a portion of the sheath. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31-65. -65. (canceled)
Specification