REMOTE CLOSED-LOOP TITRATION OF DECONGESTIVE THERAPY FOR THE TREATMENT OF ADVANCED HEART FAILURE
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Abstract
An apparatus comprises one or more physiological sensing circuits that generate a sensed physiological signal and at least one of the physiological sensing circuits is implantable, a measurement circuit configured to recurrently measure one or more physiological parameters that indicate a status of heart failure of the subject, a comparison circuit configured to compare the one or more physiological parameter measurements to one or more physiological parameter target values, a therapy circuit configured to control delivery of one or more drugs to treat heart failure, and a control circuit in electrical communication with the comparison circuit and the therapy circuit and configured to recurrently adjust delivery of drug therapy according to the comparison of the measured physiological parameters to the physiological parameter targets.
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Citations
21 Claims
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1. (canceled)
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2. An apparatus comprising:
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a cardiac therapy circuit configured to provide electrical cardiac therapeutic stimuli to treat cardiac arrhythmia; a drug therapy circuit configured to control delivery of one or more drugs to treat heart failure; a cardiac signal sensing circuit configured to generate a sensed cardiac activity signal; a measurement circuit configured to recurrently measure a first physiological parameter of a subject using the sensed cardiac activity signal, wherein the first physiological parameter indicates a status of heart failure of the subject; a comparison circuit configured to compare the measurement of the first physiological parameter to a first physiological parameter target value; and a control circuit in electrical communication with the comparison circuit, the drug therapy, and the cardiac therapy circuit, and configured to initiate delivery of drug therapy using the drug therapy circuit, recurrently initiate a comparison of the measured first physiological parameter to the first physiological parameter target value, and to adjust the drug therapy and adjust electrical cardiac therapy according to the comparison. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of operating a medical device system, the method comprising:
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recurrently measuring, using an implantable medical device, a first physiological parameter of a subject using a sensed cardiac activity signal, wherein the first physiological parameter indicates a status of heart failure of the subject; delivering device-based drug therapy to the subject; recurrently initiating a comparison of the measured first physiological parameter to a first physiological parameter target value, and adjusting the drug therapy and adjusting electrical cardiac therapy to the subject according to the comparison. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification