IMPLANTABLE PROSTHESIS HAVING ACELLULAR TISSUE ATTACHMENTS

• US 20150150674A1
• Filed: 06/18/2013
• Published: 06/04/2015
• Est. Priority Date: 06/21/2012
• Status: Active Grant

• Current Assignee: Lifecell Corporation (Abbvie Incorporated)
• Original Assignee: Lifecell Corporation (Abbvie Incorporated)
• Inventors: Ansorge, Heather, Hayzlett, Mark, Kabaria, Nimesh, Hull, Raymond, Sun, Wenquan, Roock, Timothy, Lapitan, Lawrence, Taenzer, Michael, Amato, Matthew
• Granted Patent: US 10,039,633 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 90/02 Devices for expanding tissue, e.g. skin tissue implements for holding wounds open, surgical tractors A61B17/02; implantable mammary prosthesis A61F2/12; dilators A61M29/00
• CPC Class Codes: A61F 2/0059 Cosmetic or alloplastic implants A61F2/10 - A61F2/16, A61F2/28 take precedence
• CPC Class Codes: A61F 2/12 Mammary prostheses and implants
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61F 2210/009 magnetic
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2220/0025 Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
• CPC Class Codes: A61F 2220/0033 made by longitudinally pushing a protrusion into a complementary-shaped recess, e.g. held by friction fit
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2220/0075 sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61F 2220/0091 connected by a hinged linkage mechanism, e.g. of the single-bar or multi-bar linkage type
• CPC Class Codes: A61F 2230/0004 Rounded shapes, e.g. with rounded corners
• CPC Class Codes: A61F 2230/0045 Omega-shaped
• CPC Class Codes: A61F 2230/0086 Pyramidal, tetrahedral, or wedge-shaped
• CPC Class Codes: A61F 2230/0089 tetrahedral, i.e. having a triangular basis
• CPC Class Codes: A61F 2230/0093 Umbrella-shaped, e.g. mushroom-shaped
• CPC Class Codes: A61F 2250/0003 having an inflatable pocket filled with fluid, e.g. liquid or gas
• CPC Class Codes: A61F 2250/0024 made from both porous and non-porous parts, e.g. adjacent parts
• CPC Class Codes: A61F 2250/0031 made from both resorbable and non-resorbable prosthetic parts, e.g. adjacent parts
• CPC Class Codes: A61F 2250/0051 differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts
• CPC Class Codes: A61F 2250/0071 : breakable or frangible

Abstract

A prosthesis comprising a tissue expander and one or more samples of graft material, wherein the tissue expander is attached to the one or more samples of graft material in a manner that allows the tissue expander and the one or more samples of graft material to be implanted in a patient as a unitary prosthesis; and wherein tissue expander is attached to the one or more samples of graft material in a manner that will allow the tissue expander and the graft material to separate after a period of time following implantation to allow removal of the tissue expander from an implant sites while leaving the graft material within the implant site, the prosthesis comprises a tissue expander having molded grooves, slots, channels, or other shallow cavity spaces on a surface, and wherein the graft material is within the grooves, slots, channels, or other shallow cavity spaces, securing the graft material to the tissue expander.

Claims

1. A prosthesis comprising a tissue expander and one or more samples of graft material,

wherein the tissue expander is attached to the one or more samples of graft material in a manner that allows the tissue expander and the one or more samples of graft material to be implanted in a patient as a unitary prosthesis;

and

wherein tissue expander is attached to the one or more samples of graft material in a manner that will allow the tissue expander and the graft material to separate after a period of time following implantation to allow removal of the tissue expander from an implant sites while leaving the graft material within the implant site.

2. The prosthesis of claim 1, wherein the prosthesis comprises a tissue expander having molded grooves, slots, channels, or other shallow cavity spaces on a surface, and wherein the graft material is within the grooves, slots, channels, or other shallow cavity spaces, securing the graft material to the tissue expander.

3. The prosthesis of claim 1, wherein the prosthesis comprises a biocompatible flap or pocket on a surface of the tissue expander, and wherein the graft material is within the flap or picket, securing the graft material to the tissue expander.

4. The prosthesis of claim 3, wherein the flap or pocket comprises a resorbable material.

5. The prosthesis of claim 1, wherein the tissue expander comprises one or more fixation tacks comprising one or more thin strands of biocompatible material that pass over the graft material on a surface of the tissue expander, and one or more barbs at the ends of the fixation tacks that attach to the surface of the expander to secure the graft material to the tissue expander.

6. The prosthesis of claim 5, wherein the one or more thin strands of biocompatible material comprise silicone.

7. The prosthesis of claim 5, wherein the one or more thin strands of biocompatible material comprise a resorbable synthetic material.

8. The prosthesis of claim 5, wherein the one or more thin strands of biocompatible material have a branched structure.

9. The prosthesis of claim 5, wherein the one or more samples of graft material comprise one or more holes, slits, or apertures through which the one or more thin strands of biocompatible material are passed to secure the graft material to the tissue expander.

10. The prosthesis of claim 1, wherein the prosthesis comprises one or more zip ties that secure the graft material to the tissue expander.

11. The prosthesis of claim 10, wherein the one or more zip ties comprise silicone.

12. The prosthesis of claim 10, wherein the one or more zip ties comprise a resorbable synthetic material.

13. The prosthesis of claim 10, wherein the one or more samples of graft material comprise one or more holes, slits, or apertures through which the one or more zip ties are passed to secure the graft material to the tissue expander.

14. The prosthesis of claim 1, wherein the prosthesis comprises a belt that passes over the graft material on a surface of the tissue expander, securing the graft material to the tissue expander.

15. The prosthesis of claim 14, wherein the belt comprises a silicone belt.

16. The prosthesis of claim 14, wherein the belt comprises a resorbable synthetic material.

17. The prosthesis of claim 14, wherein the belt comprises slots, and wherein the graft material is shaped to provide tabs or other shapes that will fit within the slots on the belt, thereby securing the graft material to the belt.

18. The prosthesis of claim 1, wherein the prosthesis comprises attachment points, wherein the attachment points:

comprise a dissolvable hard material;

are attached to an exterior surface of the tissue expander or underneath the exterior surface of the tissue expander; and

are in the form of dissolvable tabs, clips, balls, or buttons.

19. The prosthesis of claim 18, wherein the one or more samples of graft material comprise one or more holes, slits, or apertures through which the attachment points are passed to secure the graft material to the tissue expander.

20. The prosthesis of claim 18, wherein the hard material comprises at least one of poly-caprolactone, polylactic acid, polygalacturonic acid, polymer polyglycolic-lactic acid, polyhydroxyalkanoates, or polydioxanone.

21. The prosthesis of claim 1, further comprising one or more magnets that secure the graft material to the tissue expander.

22. The prosthesis of claim 21, wherein the tissue expander further comprises a biocompatible flap and two or more magnets, wherein at least one magnet is secured to a surface of the tissue expander and at least one magnet is secured to the flap on the tissue expander, and wherein the flap is folded over the graft material on the surface of the tissue expander and the magnet on the flap is in proximity to the magnet on the surface of the tissue expander, securing the graft material between the two magnets.

23. The prosthesis of claim 22, wherein the magnets and the flap comprise biocompatible materials.

24. The prosthesis of claim 22, wherein the flap comprises a resorbable material.

25. The prosthesis of claim 1, wherein the graft material comprises an acellular tissue matrix.

26. The prosthesis of claim 25, wherein the acellular tissue matrix comprises an adipose acellular tissue matrix that has been treated to produce a three-dimensional porous or sponge-like material.

27-38. -38. (canceled)