SYSTEMS, METHODS, AND APPARATUSES TO IMAGE A SAMPLE FOR BIOLOGICAL OR CHEMICAL ANALYSIS
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Accused Products
Abstract
A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.
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Citations
51 Claims
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1-29. -29. (canceled)
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30. A flow cell, comprising:
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a substrate having a first layer and a second layer defining a flow channel therebetween, wherein the flow channel comprises an imaging portion and a non-imaging portion, wherein the imaging and non-imaging portions are fluidicly joined by a curved portion, the imaging and non-imaging portions extending parallel to each other; an inlet port extending through the first layer and in fluid communication with the imaging portion of the flow channel; and an outlet port extending through the first layer and in fluid communication with the non-imaging portion of the flow channel, wherein the inlet port and the outlet port are located proximate to each other at one end of the flow cell, and wherein the width of the imaging portion of the flow channel is larger than the width of the non-imaging portion of the flow channel. - View Dependent Claims (31, 32, 33, 34, 35)
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36. A fluidic device for analyzing samples, the fluidic device comprising:
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a flow cell including inlet and outlet ports and a flow channel extending therebetween, the flow cell configured to hold a sample-of-interest; a housing having a reception space that is configured to receive the flow cell, the reception space being sized and shaped to permit the flow cell to float relative to the housing; and a gasket coupled to the housing, the gasket having inlet and outlet passages and comprising a compressible material, the gasket being positioned relative to the reception space so that the inlet and outlet ports of the flow cell are approximately aligned with the inlet and outlet passages of the gasket, respectively. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51)
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Specification