SYSTEMS AND METHODS FOR THERMAL ACTUATION OF MICROFLUIDIC DEVICES
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Abstract
A microfluidic processing device includes a substrate defining a microfluidic network. The substrate is in thermal communication with a plurality of N independently controllable components and a plurality of input output contacts for connecting the substrate to an external controller. Each component has at least two terminals. Each terminal is in electrical communication with at least one contact. The number of contacts required to independently control the N components is substantially less than the total number of terminals. Upon actuation, the components typically heat a portion of the microfluidic network and/or sense a temperature thereof.
29 Citations
50 Claims
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1-30. -30. (canceled)
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31. A method of using a microfluidic system, comprising:
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providing a first device comprising a first substrate defining a microfluidic network comprising at least one of each of a thermally actuated valve and a thermally actuated reaction chamber; and operatively receiving the first device in a second device, the second device comprising a second substrate defining a plurality of heat sources, each heat source being in thermal communication with a respective one of the thermally actuated valve and the thermally actuated reaction chamber of the first device, wherein at least one of the heat sources is a combined heating and temperature sensing element. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50)
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Specification