OPTIMIZING MEDICATION DOSAGE BASED ON ANALYTE SENSOR DATA
First Claim
1. A method, comprising:
- determining a first analyte level and a first rate of change of the analyte level based on analyte data received from an in vivo analyte sensor;
determining an initial medication dose based on one or more anticipated subsequent medication doses, the first analyte level relative to an analyte level threshold, and the first rate of change of the analyte level relative to a rate of change threshold;
providing an indication to administer the initial medication dose;
determining a second analyte level and a second rate of change of the analyte level based on subsequent analyte data received from the in vivo analyte sensor; and
determining a subsequent medication dose based on the second analyte level relative to the analyte level threshold and the second rate of change of the analyte level relative to the rate of change threshold.
1 Assignment
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Accused Products
Abstract
Methods, apparatuses, and systems are provided for determining whether to administer a medication dose as a single dose or whether to fractionate the single dose to be administered as at least two discrete doses. Embodiments include determining a first analyte level and a first rate of change of the analyte level; determining an initial medication dose based on one or more anticipated subsequent medication doses, the first analyte level relative to an analyte level threshold, and the first rate of change of the analyte level relative to a rate of change threshold; administering the initial medication dose; determining a second analyte level and a second rate of change of the analyte level based on subsequent analyte data; and determining a subsequent medication dose based on the second analyte level relative to the analyte level threshold and the second rate of change relative to the rate of change threshold.
26 Citations
20 Claims
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1. A method, comprising:
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determining a first analyte level and a first rate of change of the analyte level based on analyte data received from an in vivo analyte sensor; determining an initial medication dose based on one or more anticipated subsequent medication doses, the first analyte level relative to an analyte level threshold, and the first rate of change of the analyte level relative to a rate of change threshold; providing an indication to administer the initial medication dose; determining a second analyte level and a second rate of change of the analyte level based on subsequent analyte data received from the in vivo analyte sensor; and determining a subsequent medication dose based on the second analyte level relative to the analyte level threshold and the second rate of change of the analyte level relative to the rate of change threshold.
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2. The method of claim 1, further comprising providing an indication to administer the subsequent medication dose.
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3. The method of claim 2, wherein the in vivo analyte sensor is part of an integrated analyte monitoring system including a processor adapted to determine analyte levels and rate of change of analyte levels based on the analyte data from the in vivo analyte sensor.
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4. The method of claim 3, wherein providing the indication to administer the initial medication dose and the subsequent medication dose includes administering the medication doses via an automated medication delivery system.
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5. The method of claim 4, wherein the automated medication delivery system is part of the integrated analyte monitoring system.
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6. The method of claim 2, wherein the administration of the subsequent medication dose occurs in response to an input at a user interface.
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7. The method of claim 1 wherein determining the initial medication dose includes determining a time for determining the subsequent medication dose.
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8. An apparatus, comprising:
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a processor; and a memory coupled to the processor and operative to store instructions executable by the processor, the instructions including; determine a first analyte level and a first rate of change of the analyte level based on analyte data received from an in vivo sensor; determine an initial medication dose based on one or more anticipated subsequent medication doses, the first analyte level relative to an analyte level threshold, and the first rate of change of the analyte level relative to a rate of change threshold; provide an indication to administer the initial medication dose; determine a second analyte level and a second rate of change of the analyte level based on subsequent analyte data received from the in vivo sensor; and determine a subsequent medication dose based on the second analyte level relative to the analyte level threshold and the second rate of change of the analyte level relative to the rate of change threshold.
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9. The apparatus of claim 8, wherein the instructions further include an instruction to provide an indication to administer the subsequent medication dose.
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10. The apparatus of claim 9, wherein the instruction to provide the indications to administer the initial and subsequent medication doses include instructions to provide a message to a user via a user interface.
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11. The apparatus of claim 9, wherein the instructions to provide the indications to administer the initial and subsequent medication doses include instructions to transmit signals to an automated medication delivery system to administer the initial and subsequent medication doses.
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12. The apparatus of claim 11, wherein the instructions to transmit a signal to the automated medication delivery system to administer the subsequent medication dose occurs in response to an input at a user interface.
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13. The apparatus of claim 8 wherein the instruction to determine the initial medication dose includes an instruction to determine a time at which to determine the subsequent medication dose.
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14. A system, comprising:
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an analyte sensor, configured to be transcutaneously positioned through a skin layer and maintained in fluid contact with an interstitial fluid under the skin layer during a predetermined time period, the analyte sensor having a proximal portion and a distal portion; sensor electronics coupled to the analyte sensor, the sensor electronics including; a circuit board having a conductive layer and a sensor antenna disposed on the conductive layer; and one or more electrical contacts provided on the circuit board and coupled with the proximal portion of the analyte sensor to maintain electrical communication; and a receiver unit including; a processor; and a memory coupled to the processor and operative to store instructions executable by the processor, the instructions including; determine a first analyte level and a first rate of change of the analyte level based on analyte data received from the analyte sensor; determine an initial medication dose based on one or more anticipated subsequent medication doses, the first analyte level relative to an analyte level threshold, and the first rate of change of the analyte level relative to a rate of change threshold; provide an indication to administer the initial medication dose; determine a second analyte level and a second rate of change of the analyte level based on subsequent analyte data received from the analyte sensor; and determine a subsequent medication dose based on the second analyte level relative to the analyte level threshold and the second rate of change of the analyte level relative to the rate of change threshold.
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15. The system of claim 14, wherein the instructions further include an instruction to provide an indication to administer the subsequent medication dose.
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16. The system of claim 15, wherein the instructions to provide the indications to administer the initial and subsequent medication doses include instructions to provide a message to a user via a user interface.
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17. The system of claim 15, wherein the instructions to provide the indications to administer the initial and subsequent medication doses include instructions to transmit signals to an automated medication delivery system to administer the initial and subsequent medication doses.
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18. The system of claim 17, wherein the instructions to transmit a signal to the automated medication delivery system to administer the subsequent medication dose occurs in response to an input at a user interface.
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19. The system of claim 17 wherein the system includes the automated medication delivery system coupled to the receiver unit.
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20. The system of claim 14 wherein the instruction to determine the initial medication dose includes an instruction to determine a time at which to determine the subsequent medication dose.
Specification