DATA MODIFICATION FOR PREDICTIVE OPERATIONS AND DEVICES INCORPORATING SAME

• US 20150165119A1
• Filed: 12/12/2013
• Published: 06/18/2015
• Est. Priority Date: 12/12/2013
• Status: Active Grant

• Current Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Inventors: Palerm, Cesar C., Monirabbasi, Salman, Holtzclaw, Kris R., Desborough, Lane, Lintereur, Louis J.
• Granted Patent: US 9,849,240 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61M 2005/14208 with a programmable infusion control system, characterised by the infusion program
• CPC Class Codes: A61M 2005/1726 the body parameters being measured at, or proximate to, the infusion site
• CPC Class Codes: A61M 2205/3303 Using a biosensor
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2230/06 Heartbeat rate only
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 2230/63 Motion, e.g. physical activity
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device capable of delivering fluid to a user involves obtaining a sequence of measurements indicative of a condition of the user that is influenced by the fluid and modifying one or more unusable measurements in the sequence using one or more other usable measurements in the sequence to obtain a modified sequence of measurements. The method continues by determining a predicted value for the condition of the user at a time in the future based at least in part on the modified sequence of measurements and operating the infusion device in a manner that is influenced by the predicted value.

Claims

1. A method of operating a device, the method comprising:

obtaining a sequence of measurements indicative of a condition of a user;

modifying one or more unusable measurements in the sequence using one or more other measurements in the sequence to obtain a modified sequence of measurements;

determining a predicted value for the condition based at least in part on the modified sequence of measurements; and

operating the device in a manner that is influenced by the predicted value.

2. The method of claim 1, further comprising identifying an unusable measurement in the sequence, wherein modifying the one or more unusable measurements comprises replacing the unusable measurement with a modified measurement value.

3. The method of claim 2, wherein replacing the unusable measurement comprises replacing the unusable measurement with a value of a succeeding usable measurement in the sequence.

4. The method of claim 2, wherein replacing the unusable measurement comprises:

interpolating unusable measurement using a preceding usable measurement and a succeeding usable measurement in the sequence to obtain an interpolated value; and

replacing the unusable measurement with the interpolated value.

5. The method of claim 2, further comprising determining a gap between a preceding usable measurement for the unusable measurement and a succeeding usable measurement for the unusable measurement, wherein replacing the unusable measurement comprises:

replacing the unusable measurement with a value of the succeeding usable measurement in the sequence when the gap is greater than a threshold; and

when the gap is less than the threshold;

interpolating the unusable measurement using the preceding usable measurement in the sequence and the succeeding usable measurement in the sequence to obtain an interpolated value; and

replacing the unusable measurement with the interpolated value.

6. The method of claim 2, wherein identifying the unusable measurement comprises identifying an absent measurement within the sequence.

7. The method of claim 1, wherein determining the predicted value comprises determining the predicted value based at least in part on a weighted sum of values of the modified sequence of measurements.

8. The method of claim 1, the modified sequence including a current measurement for the condition, wherein determining the predicted value comprises determining the predicted value as a sum of the current measurement and a weighted sum of differences between consecutive measurements in the modified sequence that precede the current measurement.

9. The method of claim 8, further comprising:

identifying an unusable measurement in the sequence; and

determining a gap between a preceding usable measurement for the unusable measurement and a succeeding usable measurement for the unusable measurement, wherein modifying the one or more unusable measurements comprises;

replacing the unusable measurement with a value of the succeeding usable measurement in the sequence when the gap is greater than a threshold; and

when the gap is less than the threshold;

interpolating unusable measurement using the preceding usable measurement in the sequence and the succeeding usable measurement in the sequence to obtain an interpolated value; and

replacing the unusable measurement with the interpolated value.

10. The method of claim 1, the device comprising an infusion device capable of delivering fluid to a user, the fluid influencing the condition of the user, wherein operating the device comprises operating the infusion device in a manner that is influenced by the predicted value.

11. The method of claim 10, the infusion device being capable of delivering insulin to the user, wherein:

obtaining the sequence of measurements comprises obtaining a sequence of blood glucose measurements;

modifying one or more unusable measurements in the sequence comprises modifying one or more unusable blood glucose measurements in the sequence using one or more usable blood glucose measurements in the sequence to obtain a modified sequence of blood glucose measurements;

determining the predicted value comprises determining a predicted blood glucose for the user at a time in the future based at least in part on the modified sequence of blood glucose measurements; and

operating the device comprises operating the infusion device in a manner that is influenced by the predicted blood glucose in the future.

12. The method of claim 11, wherein operating the infusion device in a manner that is influenced by the predicted blood glucose comprises:

determining a dosage command based at least in part on a current blood glucose measurement in the sequence; and

adjusting the dosage command based at least in part on the predicted blood glucose in the future.

13. A system comprising:

a sensing arrangement to obtain a sequence of measurements of a condition; and

a control module coupled to the sensing arrangement, the sensing arrangement and the control module being cooperatively configured to modify a value for an unusable measurement in the sequence of measurements, resulting in a modified sequence of measurements, and determine a predicted value for the condition based at least in part on the modified sequence, wherein the control module is configured to determine a command for operating a device in a manner that is influenced by the predicted value.

14. The system of claim 13, wherein the sensing arrangement identifies the unusable measurement in the sequence, modifies the value using one or more acceptable measurements in the sequence to obtain the modified sequence, determines the predicted value based at least in part on the modified sequence, and provides the predicted value to the control module.

15. The system of claim 13, wherein:

the sensing arrangement identifies the unusable measurement in the sequence, modifies the value using one or more acceptable measurements in the sequence to obtain the modified sequence, and provides the modified sequence to the control module; and

the control module determines the predicted value based at least in part on the modified sequence received from the sensing arrangement.

16. The system of claim 13, the sensing arrangement transmitting the sequence of measurements to the device including the control module, wherein the control module identifies the unusable measurement in the sequence, modifies the value using one or more acceptable measurements in the sequence to obtain the modified sequence, and determines the predicted value based at least in part on the modified sequence.

17. The system of claim 13, the device comprising an insulin infusion device including the control module, wherein:

the sensing arrangement obtains a sequence of blood glucose measurements; and

the sensing arrangement and the control module are cooperatively configured to determine a predicted blood glucose measurement value based at least in part on the modified sequence of blood glucose measurements; and

the control module determines a dosage command for operating the insulin infusion device to deliver insulin in a manner that is influenced by the predicted blood glucose measurement value.

18. The system of claim 17, wherein:

the insulin infusion device includes a motor operable to displace a plunger to deliver the insulin to a body of a user; and

the motor is operated in a manner that is influenced by the dosage command.

19. An infusion system comprising:

a sensing arrangement to obtain a sequence of measurements of a condition in a body of a user, modify a value for an unusable measurement in the sequence to obtain a modified sequence of measurements, determine a predicted value for the condition based at least in part on the modified sequence, and transmit the predicted value and a current measurement of the condition; and

an infusion device to receive the predicted value and the current measurement, the infusion device including;

a motor operable to deliver fluid to the body of the user; and

a control module coupled to the motor to determine a command for operating the motor based at least in part on the current measurement in a manner that is influenced by the predicted value.

20. The infusion system of claim 19, wherein the sensing arrangement modifies the value by:

replacing the value for the unusable measurement with a value of a succeeding usable measurement in the sequence when a gap between the succeeding usable measurement and a preceding usable measurement exceeds a threshold; and

replacing the value for the unusable measurement with an interpolated value between the preceding usable measurement and the succeeding usable measurement when the gap is less than the threshold.